Abstract
Patulin (4-hydroxy-4H-furo(3,2) pyran-2(6H)-one) (Figure 1) has been shown to be a potent antibiotic with toxic effects in in vitro and in vivo studies (Kawasaki et al., 1972; Lindroth and von Wright, 1978; Oswald et al., 1978; Sorenson et al., 1985). Patulin is produced by many species of Aspergillus and Penicillium. Patulin was identified in 1942 by Wiesner, who observed its antibacterial activity when isolated from an Aspergillus clavatus culture. The compound was given the appropriate name “clavicin”. Today both “clavicin” and “patulin” are commonly substituted. Patulin is considered a mycotoxin because of its toxicity and possible carcinogenic effects on higher life forms (Becci et al., 1981).
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Becci, P.J., Hess, F.G., Johnson, W.D., Gallo, M.A., Babish, J.G., Daily, R.E., and Parent, R.A., (1981). Long term carcinogenicity and toxicity studies of patulin in the rat. J. Appl. Toxicol., 1, 256–261.
Chinnici, J.P., Booker, M.A., and Llewellyn, G.C., (1976). Effect of Aflatoxin B-on viability, growth, fertility, and crossing over in Drosophila melanogaster (Diptera). J. Invert. Pathol. 27, 255–258.
Gaston, J.Q., and Llewellyn, G.C., (1980). Sex-determined differential mortality of milkweed bugs, Oncopeltus fasciatus (Hemiptera), to aflatoxins. J. Invert. Pathol. 35, 195–199.
Jelnik, C.F., Pohland, A.E., and Wood, G.E., (1989). Worldwide occurrence of mycotoxins in foods and feeds— An Update. J. Assoc. Off. Anal. Chem., 72, 223–230.
Kawasaki, I., Oki, T., Umeda, M., and Saito, M. (1972). Cytotoxic effect of penicillic acid and patulin on HeLa cells. Jpn. J. Exp. Med., 42, 327–340.
Keilova-Rodova, H. (1949). The effect of patulin on tissue cultures. Experientia, 6, 242.
Lindroth, S., and von Wright, A. (1978). Comparison of the toxicities of patulin and patulin adducts formed with cysteine. Appl Environ. Microbiol., 35, 1003–1007.
Llewellyn, G.C., and Chinnici, J.P. (1978) Variation in sensitivity to aflatoxin B1 among several strains of Drosphila melanogaster (Diptera). J. Invert. Pathol. 31, 37–40.
Llewellyn, G.C., Gee, C.L., and Sherertz, P.C. (1988) Toxic responses of developing fifth instar milkweed bugs, Oncopeltus fasciatus (Hemiptera) to aflatoxin B1. Bull. Environ. Contain. Toxicol. 40, 332–338.
Llewellyn, G.C., Stephenson, G.A., and Hofman, J.W. (1977) Aflatoxin B1 induced toxicity and teratogenicity in Japanese medaka eggs (Oryzias Latipes). Toxicon 15, 582–587.
Osswald, H., Frank, H.K., Komitowski, D., and Winter, H. (1978). Long term testing of patulin administered orally to Sprague-Dawley rats and Swiss mice. Food Cosmet. Toxicol., 16, 243.
Sorenson, W.G., Simpson, J., and Castranova, V. (1985). Toxicity of the mycotoxin patulin for rat alveolar macrophages. Environ. Res., 38, 407–416.
Sherertz, P.C., Mills, R.R., and Llewellyn, G.C. (1978) Comparative dietary patterns and body weight changes in adult male american cockroaches fed pure aflatoxin B1. Bull. Environm. Toxicol. 20, 687–695.
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Llewellyn, G.C., Llewellyn, G.C. (1990). The Effects of Patulin on the Development of Oncopeltus fasciatus . In: Llewellyn, G.C., O’Rear, C.E. (eds) Biodeterioration Research. Biodeterioration Research, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9453-3_21
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DOI: https://doi.org/10.1007/978-1-4757-9453-3_21
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