Abstract
Following a single therapeutic dose many psychotropic drugs are present in plasma at sub-ng concentrations. As a consequence many of the pharmacokinetic parameters of these drugs have been derived from steady-state data using relatively insensitive analytical methodology. In order to gain pharmacokinetic data from a single dose it is necessary to develop a routine assay with high sensitivity and specificity. This requires optimization of Chromatographic and extraction conditions, as now briefly illustrated for two psychotropic agents — thiothixene (TTX), and flurazepam together with its major metabolites desalkylflurazepam (DAF) and hydroxyethylflurazepam (HEF).
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© 1988 Springer Science+Business Media New York
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Hill, H.M., Lessard, D., Letarte, L. (1988). Optimization of Capillary GC Conditions for the Analysis of Psychotropic Drugs at Subnanogram Concentrations in Plasma. In: Reid, E., Robinson, J.D., Wilson, I.D. (eds) Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular. Methodological Surveys in Biochemistry and Analysis, vol 18 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9424-3_38
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DOI: https://doi.org/10.1007/978-1-4757-9424-3_38
Publisher Name: Springer, Boston, MA
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