Abstract
Satisfactory procedures are needed for the assay in plasma of nitroglycerin (glyceryl trinitrate, GTN) and denitrated metabolites, two isomeric dinitroglycerols (1,2- and 1,3-GDN) and mononitroglycerol (GMN; 2 isomers). Besides glycerol itself, metabolism also furnishes inorganic nitrite and, therefrom by reaction with GSH (forming GSSG), nitrate; the desirability of being able to measure these 4 analytes was pointed out at the 1985 Bioanalytical Forum ([1], wherein p. 111 shows metabolic pathways) but is not pursued here.
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References
Curry, S.H. (1986) in Bioactive Analytes, including CNS Drugs, Peptides and Enantiomers [Vol. 16, this series] (Reid, E., Scales, B. & Wilson, I.D., eds.), Plenum, New York, pp. 109–112.
Curry, S.H., Algozzini, G. & Yu, W. (1984) in Drug Determination in Therapeutic and Forensic Contexts [Vol. 14, this series] (Reid, E. & Wilson, I.D., eds.), Plenum, New York, pp. 367–368.
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Curry, S.H. & Aburawi, S. (1985) Biopharmaceuties & Drug Disp. 6. 235–280.
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Curry, S.H., Kwon, HR. (1988). Assay of Nitroglycerin and Metabolites by Capillary GC. In: Reid, E., Robinson, J.D., Wilson, I.D. (eds) Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular. Methodological Surveys in Biochemistry and Analysis, vol 18 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9424-3_27
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DOI: https://doi.org/10.1007/978-1-4757-9424-3_27
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