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Bacterial Growth and Lysis pp 183–188Cite as

Does PBP2 Regulate Cell Division in E. coli?

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Part of the book series: Federation of European Microbiological Societies Symposium Series ((FEMS,volume 65))

Abstract

Although penicillin has not made war humane, it probably saved over a million lives during World War II. The action of penicillin and related β-lactam antibiotics was early recognized to be extrmely broad, affecting the vast majority of bacterial species, and at the same time highly specific, generally producing little effect on eukaryotic cells. As the complex structure of the bacterial cell wall became known, the mechanism of action of β-lactams was also revealed: they bind covalently to the PBPs (‘penicillin binding proteins’), a set of integral membrane proteins which catalyse the terminal steps in the synthesis of the rigid peptoglycan wall (for review see Waxman and Strominger, 1983; Ghuysen, 1991).

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Authors and Affiliations

  1. Institut Jacques Monod, C.N.R.S., Université Paris 7, 2, place Jussieu, F-75251, Paris Cedex 05, France

    Philippe Bouloc, Daniel Vinella, Danièle Joseleau-Petit & Richard D’Ari

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  1. Philippe Bouloc
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  2. Daniel Vinella
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  3. Danièle Joseleau-Petit
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  4. Richard D’Ari
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Editors and Affiliations

  1. Centro de Biología Molecular, CSIC-UAM, Madrid, Spain

    M. A. de Pedro

  2. Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Germany

    J.-V. Höltje

  3. Institut für Allgemeine Biochemie, Universität Wien, Wien, Austria

    W. Löffelhardt

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Bouloc, P., Vinella, D., Joseleau-Petit, D., D’Ari, R. (1993). Does PBP2 Regulate Cell Division in E. coli?. In: de Pedro, M.A., Höltje, JV., Löffelhardt, W. (eds) Bacterial Growth and Lysis. Federation of European Microbiological Societies Symposium Series, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9359-8_21

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  • DOI: https://doi.org/10.1007/978-1-4757-9359-8_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9361-1

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