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Virus Variability, Epidemiology and Control pp 61–73Cite as

Escape of Lentiviruses from Immune Surveillance

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Part of the book series: Applied Virology Research ((AVIR,volume 2))

Abstract

Lentiviruses arc nononcogenic retroviruses that cause chronic disease in persistently infected individuals. The viruses are transmitted exogenously and replicate productively in terminally differentiated cells of the immune system. Lentiviruses are transmitted in body fluids and infection often remains inapparent for months or years. Disease begins insidiously and infected individuals eventually develop a chronic multisystemic disease manifest as wasting, immune dysfunction, dyspnea, or neurologic impairment. The viruses are species-specific and members of this group infect a variety of hosts causing unique disease syndromes in each host species. However, the members of the lentivirus group share a remarkable number of biologic, morphologic, and structural features which define this subfamily of viruses (Narayan and Clements, 1987; Haase, 1986).

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Author information

Authors and Affiliations

  1. Division of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, 21205

    David L. Huso

  2. Division of Comparative Medicine and Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, 21205

    Opendra Narayan

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  1. David L. Huso
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  2. Opendra Narayan
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Editors and Affiliations

  1. Department of Microbiology and Immunology, Faculty of Medicine, University of Montreal, H3C 3J7, Montreal, Quebec, Canada

    Edouard Kurstak

  2. University of Alberta, Edmonton, Alberta, Canada

    R. G. Marusyk

  3. Center for Disease Control, Atlanta, Georgia, USA

    F. A. Murphy

  4. Institute of Molecular and Cellular Biology, Strasbourg, France

    M. H. V. Van Regenmortel

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Huso, D.L., Narayan, O. (1990). Escape of Lentiviruses from Immune Surveillance. In: Kurstak, E., Marusyk, R.G., Murphy, F.A., Van Regenmortel, M.H.V. (eds) Virus Variability, Epidemiology and Control. Applied Virology Research, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9271-3_5

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