Abstract
This study compared the BIOMIC system to the Vitek system to determine the percentage of agreement between the minimum inhibitory concentrations. The BIOMIC semi-automated system employs disk diffusion test zone diameters to determine minimum inhibitory concentrations. Results were in agreement when the BIOMIC minimum inhibitory concentration was within ± 1 doubling dilution of the Vitek result. A total of 137 clinical isolates, including Enterobacteriaceae, non-fermenters, staphylococci, and enterococci were tested. The overall agreement for 1335 organism/drug combinations was 85%, with 10% minor and 5% major discrepancies. The agreement by organism group was 87% for Enterobacteriaceae, 87% for nonfermenters, and 79% for enterococci and staphylococci. Antimicrobic combinations that exhibited a high discrepancy rate included tetracycline vs. Enterobacteriaceae (39%) and amikacin vs. nonfermenters (30%). An agreement of 100% was found for ciprofloxacin and imipenem vs. nonfermenters, as well as for clindamycin and oxacillin vs. staphylococci. This study showed the BIOMIC system to be an acceptable, cost-effective alternative for determining minimum inhibitory concentrations.
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© 1994 Springer Science+Business Media New York
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Wolfram, T.L., McFarland, C.R., Poupard, J.A. (1994). Correlation of Minimum Inhibitory Concentration Results between the Vitek System and the Biomic System. In: Poupard, J.A., Walsh, L.R., Kleger, B. (eds) Antimicrobial Susceptibility Testing. Advances in Experimental Medicine and Biology, vol 349. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9206-5_18
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DOI: https://doi.org/10.1007/978-1-4757-9206-5_18
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