The Corneal Model for the Study of Angiogenesis

Abstract

Many models for the study of the processes taking place during angiogenic reactions in vivo have been designed. Due to the complexity of the reactions leading to the growth of new vessels in vivo adequate interpretation of the observed processes is, in most cases, difficult. The phenomena in vivo are generally the end results of complex reactions, interactions and feedback mechanisms, most of which remain unknown. In order to enhance accuracy, the in vivo models have to be as simple as possible and amenable to direct visualization and follow-up. Furthermore, a thorough knowledge regarding the anatomy, physiology and histopathology of the organ used is mandatory.