Summary
Lipoprotein (a) [Lp(a)] is a subclass of low density lipoproteins (LDL) whose elevated blood concentrations constitute an independent risk factor for coronary artery disease (CAD). Lipoprotein (a) derives its uniqueness from an appendage, apolipoprotein (a), which is linked to the apolipoprotein B-100 portion of LDL. Apolipoprotein (a) has been found to display a remarkable homology with plasminogen. This homology has lead to suggestions that there may be competition between Lp(a) and plasminogen for binding to fibrin, and to cell membranes. Consequently, much attention has been paid to interactions between fibrin, Lp(a), and plasmin and to the linkage of thrombosis and atherogenesis.
In contrast, this study draws attention at the cholesterol rich component of Lp(a) which is identical to LDL, investigates its oxidation and the role of oxidized Lp(a) in activating resident intimai macrophages. It provides evidence that oxidatively modified Lp(a), enhanced the expression of surface antigens on U937 cells and stimulated adhesion of U937 cells to cultured endothelial cells. These results suggest that oxidatively modified Lp(a) like oxidized LDL behaves as an inducer of differentiation, adhesion and activation of monocytes, leading to the hypothesis that oxidized Lp(a) may play an important role in atherogenesis, and CAD.
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Ragab, M., Selvaraj, P., Sgoutas, D.S. (1994). Interactions between Oxidized Lipoprotein (a) [Lp(a)], Monocytes and Endothelial Cells. In: Maragoudakis, M.E., Gullino, P.M., Lelkes, P.I. (eds) Angiogenesis. NATO ASI Series, vol 263. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9188-4_13
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DOI: https://doi.org/10.1007/978-1-4757-9188-4_13
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