Abstract
Malignant progression designates the biologic process which transforms a phenotypically normal cell fixed and cooperating within a tissue into a disseminated therapy-resistant lethal disease. In clinical terms this process consists of three major steps (Fig. 1):
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() the transition from regulated to deregulated cell proliferation,
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() the emerging ability of the neoplastic cell collectives to induce angiogenesis and to invade other tissues,
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() the development of metastases and of resistance towards anti-tumor therapies.
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Höckel, M., Schlenger, K., Aral, B., Schäffer, U., Weikel, W. (1998). Tumor Vascularity, Hypoxia, and Malignant Progression in Solid Neoplasms. In: Maragoudakis, M.E. (eds) Angiogenesis. NATO ASI Series, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9185-3_38
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DOI: https://doi.org/10.1007/978-1-4757-9185-3_38
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