Abstract
The steps required for new vessel growth are biologically complex and require coordinate regulation of contributing components, including modifications of cell-cell interactions, proliferation and migration of endothelial cells and matrix degradation involving urokinase-type plasminogen activator (uPA) (Mignatti et al., 1991). The observation that in vivo angiogenesis is accompanied by vasodilation and that many angiogenesis effectors possess vasodilating properties, prompted us to search for evidence of a molecular/ biochemical link between vasodilation and angiogenesis. Indeed both events occur under a strict control exerted by the endothelial cells on the surrounding cellular components.
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Brown, L.F., Berse, T., Jackman, R.W., Tognazzi, A., Manseau, E.J., Dvorak, H.F., and Senger, D.R. 1993. Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am. J. Pathol.143: 1255–1262.
Brzozowski, T., Kounturek, S.J., Drozdowicz, D., Dembinski, A., and Stachura, J. 1995. Healing of chronic gastric ulcerations by L-arginine. Digestion 56: 463–471.
Claffey, K.P., Brown, L.F., del Aguila, L.F., Tognazzi, K., Yeo, K.-T., Manseau, E.J., and Dvorak, H.F. 1996. Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res.56: 172–181.
Clark, E.R., and Clark, E.L. 1939. Microscopic observations on the growth of blood capillaries in the living mammal. Am. J. Anat.64:251–299
Cobbs, CS., Brenman, J.E., Alpade, K.D., Bredt, D.S., and Israel, M.A. 1995. Expression of nitric oxide synthase in human central nervous system tumors. Cancer Res.55: 727–730.
Doi, K., Akaike, T., Horie, H., Noguchi, Y., Fuji, S., Beppu, T., Ogawa, M., and Maeda, H. 1996. Excessive production of NO in rat solid tumor and its implication in rapid tumor growth. Cancer 11: 1598–1604.
Feelish, M., and Noack, E. 1987. Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron. Eur. J. Pharmacol.142:465–469.
Ferrara, N., and Henzel, W.J. 1989. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun.161: 851–858.
Friedlander, M., Brooks, P.C., Shaffer, R.W., Kincaid, C.M., Varner, J.A., and Cheresh, D.A. 1995. Definition of two angiogenic pathways by distinct av integrins. Science 270: 1500–1502.
Ghigo, D., Arese, M., Todde, R., Vecchi, A., Silvagno, F., Costamagna, C, et al. 1995. Middle T antigen-transformed endothelial cells exhibit an increased activity of nitric oxide synthase. J. Exp. Med.181: 9–19.
Hu, D.E., and Fan, T.-P.D. 1993. [Leu8]des-Arg9-bradykinin inhibits the angiogenic effect of bradykinin and interleukin-1 in rats. Br. J. Pharmacol. 109: 14–17.
Jenkins, D.C., Charles, LG., Thomsen, L.L., Moss, D.W., Holmes, LS, Baylis, S.A., Rhodes, P., Westmore, K., Emson, P.C., and Moncada, S. 1995. Role of nitric oxide in tumor angiogenesis. Proc. Natl. Acad. Sei. USA 92: 4392–4396.
Keck, P.J, Hauser, S.D., Krivi, G., Sanzo, K., Warren, T., Feder, J., and Conolly, D.T. 1989. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309–1312.
Kennovin, G.D., Hirst, D.G., Stratford, M.R.L., and Flitney, F.W. 1994. Inducible nitric oxide synthase is expressed in tumor associated vasculature; inhibition retards tumor growth in vivo. In Biology of Nitric Oxide Vol. 4 Enzymology, Biochemistry and Immunology. S. Moncada, M. Feelish, R. Busse, and E.A. Higgs, editors. Portland Press, London. 473–479.
Kourembanas, S., McQuillan, L. P., Leung, G. K, and Faller, D. V. 1993. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J. Clin. Invest.92:99–104.
Ku, D.D., Zaleski, J.K., Liu, S., and Brock, T.A. 1993. Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries. Am. J. Physiol. 265: H586-H592.
Leibovicz, JS, Polverini, P.J., Fong, T.W., Harlow, L.A., and Kock, A. E. 1994. Production of angiogenic activity by human monocytes requires an L-arginine/nitric oxide- synthase-dependent effector mechanism. Proc. Natl. Acad. Sci. USA 91: 4190–4194.
McNeil, P.L., Muthukrishnan, L., Warder, E., and D’Amore, P.A. 1989. Growth factors are released by mechanically wounded cells. J. Cell Biol.109: 811–822.
Mignatti, P., Mazzieri, R., and Rifkin, D.B. 1991. Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor. J. Cell Biol.113: 1193–1201.
Mignatti, P., Tsuboi, R., Robbins, E., and Rifkin, D.B. 1989. In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases. J. Cell Biol.108: 671–682.
Moncada, S., and Higgs, A. 1993. The L-arginine-nitric oxide pathway. New Engl. J. Med.329: 2002–2012.
Moncada, S., Palmer, R. M. J., and Higgs, A. 1991. Nitric Oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev.43:109–142.
Montrucchio, G., Lupia, E., De Martino, A., Battaglia, E., Arese, M., Tizzani, A., Bussolino, F., and Camussi, G. 1997. Nitric oxide mediates angiogenesis induced in vivo by platelt-activating factor and tumor necrosis factor. Am. J. Pathol.151: 557–563.
Morbidelli, L., Chang, C.-H., Douglas, JG., Granger, HJ., Ledda, F., and Ziche, M. 1996. Nitric oxide mediates the mitogenic effect of VEGF on coronary venular endothelium. Am J. Physiol.270(39): H411-H415.
Mulsh, A., Buse, R., Liebau, S., and Fostermann, U. 1988. LY 83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase. J. Pharmacol. Exp. Ther.247: 283–288.
O’Brien, T., Cranston, D., Fuggle, S., Bicknell, R, and Harris, A.L. 1996. Different angiogenic pathways characterize superficial and invasive bladder cancer. Cancer Res.55: 510–513.
Orucevic, A., and Lala, P.K. 1996. N-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis, ameliorates interleukin 2-induced capillary leakage and reduces tumour growth in adenocarcinoma-bearing mice. Br. J. Cancer 73: 189–196.
Pipili-Synetos, E., Sakkoula, E., Haralabopoulos, G., Andiopuolou, P., Peristeris, P., and Maragoudakis, M.E. 1994. Evidence that nitric oxide is an endogenous antiangiogenic mediator. Br. J. Pharmacol.111: 894–902.
Plate, K.H., Breier, G., Weich, H.A., and Risau, W. 1992. Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature 359: 845–848.
Presta, M., Moscatelli, D., Joseph-Silverstein, J., and Rifkin, D.B. 1986. Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis and migration. Mol. Cell. Biol.6:4060–4066.
Sato, Y., and Rifkin, D.B. 1988. Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis and DNA synthesis. J. Cell Biol.107:1199–1205.
Schweigerer, L., Neufeld, G, Freidman, J., Abraham, JA., Fiddes, J.C., and Gospodarowicz, D. 1987. Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth. Nature 352:257–259.
Shweiki, D., Itin, A., Soffer, D., and Keshet, E. 1992. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843–845.
Thomsen, L.L., Lawton, FG., Knowles, R.G., Beesley, JE., Riveros-Moreno, V., and Moncada, S. 1994. Nitric oxide synthase activity in human gynecological cancer. Cancer Res.54: 1352–1354.
Toi, M., Kondo, S., Suzuki, H., Yamamoto, Y., Inada, K., Imazawa, T., Taniguchi, T., and Tominaga, T. 1996. Quantitative analyses of vascular endothelial growth factor in rimary breast cancer. Cancer Res.11: 1101–1105.
Tsuboi, R., Sato, Y., and Rifkin, D.B. 1990. Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells. J. Cell Biol 110:511–517.
Wolff, J.E.A., Guerin, C, Laterra, J., Bressler, J., Indurti, R.R., Brem, H., and Goldstein, G.W. 1993. Dexamethasone reduces vascular density and plasminogen activator activity in 9L rat brain tumors. Brain Res.604: 79–85.
Wu, H.M., Qiaobing, H, Yuan, Y, and Granger, H.J. 1996. VEGF induces NO-dependent hyperpermeability in coronary venules. Am. J. Physiol.269 (38): C1371-C1378, 1995.
Xie, K., Huang, S., Dong, Z., Juang, S.-H., Wang, Y., and Fidler, I.J. 1997. Destruction of bystander cells by tumor cells transfected with inducible nitric oxide (NO) synthase gene. J. Natl. Cancer Inst.89: 421–427.
Zhang, H.-T., Craft, P., Scott, P.A.E, Ziehe, M., Weich, H.A., Harris, A.L., and Bicknell, R. 1995. Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells. J. Natl. Cancer Inst.87: 213–217.
Ziche, M., Morbidelli, L., Choudhuri, R., Zhang, H.-T., Donnini, S., Granger, H.J., and Bicknell, R. Nitric oxide-synthase lies downstream of Vascular Endothelial Growth Factor but not basic Fibroblast Growth Factor induced angiogenesis. J. Clin. Invest., 99: 2625–2634, 1997.
Ziehe, M., Morbidelli, L., Geppetti, P., Maggi, CA., and Dolara, P. 1991. Substance P induces migration of capillary endothelial cells: a novel NK-1 selective receptor mediated activity. Life Sci. 48: PL7-PL11.
Ziehe, M., Morbidelli, L., Masini, E., Amerini, S., Granger, HJ., Maggi, CA., Geppetti, P., and Ledda, F. 1994. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J. Clin. Invest. 94:2036–2044.
Ziehe, M., Morbidelli, L., Masini, E., Granger, H.J., Geppetti, G., and Ledda, F. 1993. Nitric oxide promotes DNA synthesis and cyclic GMP formation in endothelial cells from postcapillary venules. Biochem. Biophys. Res. Commun.192 (3): 1198–1203.
Ziehe, M., Morbidelli, L., Pacini, M., Geppetti, P., Alessandri, G., and Maggi, CA. 1990. Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells. Microvasc. Res.40: 264–278.
Ziehe, M., Morbidelli, L., Parenti, A., Amerini, S., Granger, H.J., and Maggi, CA. 1993. Substance P increases cyclic GMP levels on coronary postcapillary venular endothelial cells. Life Sci.53:1105–1112.
Ziehe, M., Parenti, A., Ledda, F., Dell’Era, P., Granger, HJ., Maggi, CA., and Presta, M. 1997. Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF. Circ. Res., 80: 845–852
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Ziche, M. (1998). Nitric Oxide and Angiogenesis. In: Maragoudakis, M.E. (eds) Angiogenesis. NATO ASI Series, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9185-3_29
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DOI: https://doi.org/10.1007/978-1-4757-9185-3_29
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