Summary
ANCA were detected in 67% of sera from patients with primary sclerosing cholangitis (n=15), in 83% of sera from patients with auto-immune chronic active hepatitis (n=18) and in 35% of sera from patients with primary biliary cirrhosis (n=20). ANCA were not detected in non-autoimmune chronic liver diseases. Characterization studies of the antigens involved showed that ANCA in autimmune liver disease are not directed against myeloperoxidase (mpo), proteinase 3 (pr3) or elastase (hle), but that ANCA in autoimmune liver disease show reactivity with lactoferrin, a 67/66 kD protein combination or a 63/54 kD protein combination on Western Blots.
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© 1993 Springer Science+Business Media New York
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Mulder, A.H.L., Horst, G., Haagsma, E.B., Kleibeuker, J.H., Kallenberg, C.G.M. (1993). Anti-Neutrophil Cytoplasmic Antibodies (ANCA) in Autoimmune Liver Disease. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_99
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DOI: https://doi.org/10.1007/978-1-4757-9182-2_99
Publisher Name: Springer, Boston, MA
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