Abstract
Histologically identical cutaneous leukocytoclastic angiitis occurs in patients with different serologic markers for vasculitis. When categorized on the basis of serologic analysis for antineutrophil cytoplasmic autoantibodies and IgA fibronectin aggregates, categories of leukocytoclastic angiitis have many overlapping features; however, there are distinctive clinical and immunopathologic trends among the categories. When both serologic tests are negative, there is a low probability that systemic vasculitis is present. The presence of either serologic marker indicates a strong probability for the presence of extracutaneous vasculitis and/or glomerulonephritis.
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References
Jennette J.C., Falk R.J., 1990, Anti-neutrophil cytoplasmic autoantibodies and associated diseases: A review. Am JKidney Dis 15:517
Jennette J.C., Wieslander J., Tuttle R., Falk R.J., Glomerular Disease Collaborative Network, 1991, Serum IgA-fibronectin aggregates in patients with IgA nephropathy and Henoch-Schönlein purpura: Diagnostic value and pathogenic implications. Am JKidney Dis 18:466
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© 1993 Springer Science+Business Media New York
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Jennette, J.C., Tuttle, R., Falk, R.J. (1993). The Clinical, Serologic, and Immunopathologic Heterogeneity of Cutaneous Leukocytoclastic Angiitis. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_52
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DOI: https://doi.org/10.1007/978-1-4757-9182-2_52
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9184-6
Online ISBN: 978-1-4757-9182-2
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