Summary
Myeloperoxidase (MPO) and proteinase-3 (Pr-3) can bind to vascular endothelial cells (EC) and are available for recognition by autoantibodies present in P-ANCA or C-ANCA containing sera, respectively. The bound MPO also retains its enzymic functions and effectively interacts with hydrogen peroxide to mediate detachment of endothelial cells from their substratum. EC bound MPO-anti-MPO complexes can contribute to the complement-dependent EC injury demonstrated by some P-ANCA sera.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Falk, R.J., Terrell, R.S., Charles, L.A. and Jennette, J.C., 1990, Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro, Proc Natl Acad Sci USA. 87: 4115–4119
Savage, C.O.S., Pottinger, B., Gaskin, G., Lockwood, C.M., Pusey, C.D. and Pearson, J., 1991, Vascular damage in Wegener’s granulomatosis and microscopic polyarteritis: presence of anti-endothelial cell antibodies and their relation to anti-neutrophil cytoplasm antibodies, Clin exp Immunol. 85: 14–19
Savage, C.O.S., Pottinger, B.E., Gaskin, G., Pusey, C.D. and Pearson, J.D., 1992, Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity towards cultured endothelial cells. Am J Pathol. 144: 335–342
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Savage, C.O.S., Gaskin, G., Pusey, C.D., Pearson, J.D. (1993). Myeloperoxidase Binds to Vascular Endothelial Cells, is Recognized by ANCA and can Enhance Complement Dependent Cytotoxicity. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_20
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9182-2_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9184-6
Online ISBN: 978-1-4757-9182-2
eBook Packages: Springer Book Archive