Skip to main content
SpringerLink
Log in

Chemistry of Collagen Crosslinking: Relationship to Aging and Nutrition

  • Chapter
Protein Crosslinking

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 86))

Abstract

Collagen is a major constituent of skin, bone, tendon, and cartilage and is a vital component of the cardiovascular system. Not only is collagen an important protein because of its relative abundance, estimates indicate that it constitutes as much as 40% of the total body protein, but also it is the only protein in the body that has been clearly shown to undergo molecular changes during the aging process in man and animals, i. e., it “ages.” One of the outward manifestations of aging in collagen is the wrinkling of the skin which is inevitable in the elderly. Another, which is not so obvious but is of infinitely greater importance to man is the age-associated loss of elasticity in the cardiovascular system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Wertheim, M. G., Ann. Chim. et Phys. 21, 385 (1847).

    Google Scholar 

  2. Rollhäuser, H., Gegenbaurs Morph. Jb. 90, 157 (1950).

    Google Scholar 

  3. Mendoza, S. A. and Milch, R. A., Gerontologia 10, 42 (1964).

    Article  PubMed  Google Scholar 

  4. Nimni, M. E., DeGuia, E. and Baretta, L. A., Nature 207, 865 (1965).

    Article  PubMed  CAS  Google Scholar 

  5. Verzar, F., Experientia 11, 230 (1955).

    Google Scholar 

  6. McClain, P. E., Pearson, A. M., Miller, E. R. and Dugan, L. R., Biochem. Biophys. Acta 168, 143 (1968).

    Article  CAS  Google Scholar 

  7. Brown, P. C. and Consden, R., Nature 181, 349 (1958).

    Article  PubMed  CAS  Google Scholar 

  8. Schaub, M. C., Gerontologia 8, 114 (1963).

    Article  CAS  Google Scholar 

  9. Verzar, F., Gerontologia 4, 105 (1960).

    Google Scholar 

  10. McClain, P. E., Proc. 29th Ann. Rec. Meat Conf. In Press (1976).

    Google Scholar 

  11. McClain, P. E., Kuntz, E. and Pearson, A. M., Agr. and Food Chem. 17, 629 (1969).

    Article  CAS  Google Scholar 

  12. Shimokamaki, M., Elsden, D. F. and Bailey, A. J., J. Food Sci. 37, 892 (1972).

    Article  Google Scholar 

  13. Bailey, A. J., Robins, S. P. and Balian, G., Nature, 251, 105 (1974).

    Article  PubMed  CAS  Google Scholar 

  14. Prockop, D., Kaplan, A. and Undenfriend, S., Arch. Biochem. Biophys. 101, 499 (1963).

    Article  PubMed  CAS  Google Scholar 

  15. Rhoads, R. E. and Undenfriend, S., Proc. Natl. Acad. Sci. U. S. 60, 1473 (1968).

    Google Scholar 

  16. Bhatnagar, R. S., Rapaka, S. R., Liu, R. Z. and Wolfe, S. M., Biochim. Biophys. Acta 271, 125 (1972).

    Article  CAS  Google Scholar 

  17. Hayaishi, 0., In: Biological Oxidations Ed. T. P. Singer, New York, Interscience P. 581 (1968).

    Google Scholar 

  18. Hutton, J J., Jr., Tappel, A. L. and Undenfriend, S., Arch. Biochem. Biophys. 118, 231 (1967).

    Article  CAS  Google Scholar 

  19. Stassen, F. L. H., Gardinale, G. J. and Unden Friend, S., Proc. Natl. Acad. Sci. U. S., 70, 1090 (1973).

    Article  CAS  Google Scholar 

  20. Berg, R. A. and Prockop, D. J., Biochem. Biophys. Res. Commun., 52, 115 (1973).

    Article  CAS  Google Scholar 

  21. Jimenez, S., Harsch, M. and Rosenbloom, J., Biochem. Biophys. Res. Commun., 52, 106 (1973).

    Article  CAS  Google Scholar 

  22. Toole, B. P., Kang, A. H., Trelstad, R. L. and Gross, J., Biochem. J. 127, 715 (1972).

    PubMed  CAS  Google Scholar 

  23. Barnes, M. J., Constable, B. J., Morton, L. F. and Kodicek, E., Biochem. J. 132, 113 (1973).

    PubMed  CAS  Google Scholar 

  24. Mechanic, G. L., Toverud, S. V. and Ramp, W. K. Biochem. Biophys. Res. Commun. 47, 760 (1972).

    CAS  Google Scholar 

  25. Asling, C. W. and Hurley, L. S., Clin. Orthoped. 23, 213 (1963).

    Google Scholar 

  26. Shields, G. S., Coulson, W. F., Kimball, D. A., Carnes, W. H., Cartwright, G. E. and Wintrobe, M. M., Am. J. Pathol. 41, 603 (1962).

    PubMed  CAS  Google Scholar 

  27. O’Dell, B. L., Hardwick, B. C., Reynold, G. and Savage, J. E., Proc. Soc. Exptl. Biol. Med., 108, 402 (1961).

    Article  Google Scholar 

  28. Chou, W. S., Savage, J. E. and O’Dell, B. L., Proc. Soc. Exp. Biol. Med., 128, 948 (1968).

    Article  CAS  Google Scholar 

  29. Harris, E. D. and O’Dell, B. L., Adv. in Exp. Med. and Biol. 48, 267 (1974).

    Google Scholar 

  30. Savage, J. E., Bird, D. W., Reynolds, G. and O’Dell, B. L. J. Nutr. 88, 15 (1966).

    PubMed  CAS  Google Scholar 

  31. Todd, W. R., Elvejhem, C. A. and Hart, H. B., Am. J. Physiol. 107, 146 (1934).

    CAS  Google Scholar 

  32. Pories, W. J., Henzel, J. H., Rob, C. G. and Strain, W. H., Lancet 1, 121 (1967).

    Article  PubMed  CAS  Google Scholar 

  33. McClain, P. E., Wiley, E. R., Beecher, G. R., Anthony, W. L. and Hsu, J. M., Biochem. Biophys. Acta 304, 457 (1973).

    Article  CAS  Google Scholar 

  34. Pories, W. J., Henzel, J. H., Rob, C. G. and Strain, W. H., Ann. Surg. 165, 432 (1967).

    Article  PubMed  CAS  Google Scholar 

  35. McKay, C. M., Amer. J. Publ. Hlth. 37, 521 (1947).

    Article  Google Scholar 

  36. Chvapil, M. and Hruza, Z., Gerontologia 3, 241 (1959).

    Article  PubMed  CAS  Google Scholar 

  37. Deyl, Z. and Rosmus, J., Exp. Geront. 3, 177 (1968).

    Article  CAS  Google Scholar 

  38. Prasad, C. U. and Bose, S. M., Nutr. Metabol. 16, 172 (1974).

    Article  CAS  Google Scholar 

  39. McClain, P. E., Wiley, E. R. and Beecher, G. R., Nutr. Rep. Int. 12, 317 (1975).

    CAS  Google Scholar 

  40. McClain, P. E. and Wiley, E. R. Fed. Proc. 30, 402A (1971).

    Google Scholar 

  41. Beisswenger, P. J. and Spiro, R. G. Science, 168, 596 (1970).

    Article  CAS  Google Scholar 

  42. Sinex, F. M., In: Treatise on Collagen Ed. B. S. Gould. New York: Academic Press p. 409 (1968).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. U. S. Department of Agriculture, Agricultural Research Service, Nutrition Institute, Beltsville, Maryland, 20705, USA

    Philip E. McClain

Authors
  1. Philip E. McClain
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Western Regional Research Laboratory, U.S. Department of Agriculture, Agricultural Research Service, Berkeley, California, USA

    Mendel Friedman

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Springer Science+Business Media New York

About this chapter

Cite this chapter

McClain, P.E. (1977). Chemistry of Collagen Crosslinking: Relationship to Aging and Nutrition. In: Friedman, M. (eds) Protein Crosslinking. Advances in Experimental Medicine and Biology, vol 86. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9113-6_34

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9113-6_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9115-0

  • Online ISBN: 978-1-4757-9113-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation