Skip to main content

A Mathematical Analysis of Kinetics of Consecutive, Competitive Reactions of Protein Amino Groups

  • Chapter
Protein Crosslinking

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 86))

Abstract

A general mathematical analysis of consecutive, competitive reactions of amino groups in amino acids, peptides, and proteins was developed. The analysis is of more than theoretical interest, and should prove useful for interpretation of the reactivity and utility of reagents that modify lysine in proteins.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cavins, J. F., and Friedman, M. (1967). New amino acids derived from reactions ofe-amino groups in proteins with a,13-unsaturated compounds. Biochemistry, 6, 3766–3770.

    CAS  Google Scholar 

  2. Finley, J. W., and Friedman, M. (1973). Chemical methods for available lysine. Cereal Chem., 50, 101–105.

    CAS  Google Scholar 

  3. Friedman, M. (1967). Solvent effects in reactions of amino groups in amino acids, peptides, and proteins with a,13-unsaturated compounds. J. Am. Chem. Soc., 89, 4709–4713.

    Article  PubMed  CAS  Google Scholar 

  4. Friedman, M. (1968). Solvent effects in reactions of protein functional groups. Quarterly Reports on Sulfur Chemistry, 3, 125–144.

    Google Scholar 

  5. Friedman, M. (1977). Effects of lysine modification on chemical, physical, nutritive, and functional properties of proteins. In “Fundamental Aspects of Protein Chemistry Basic to Foods,” edited by J. R. Whitaker and S. R. Tannenbaum. Avi, Westport, Connecticut.

    Google Scholar 

  6. Friedman, M., and Finley, J. W. (1975a). Reactions of proteins with ethyl vinyl sulfone. Int. J. Peptide Protein Res., 7, 481–486.

    Article  CAS  Google Scholar 

  7. Friedman M., and Finley, J. W. (1975b). Vinyl compounds as reagents for available lysine. In “Protein Nutritional Quality of Foods and Feeds,” Part 1, M. Friedman (Editor), Dekker, New York, pp. 503–520.

    Google Scholar 

  8. Friedman, M., and Koenig, N. H. (1971). Effect of dimethyl sulfoxide on chemical and physical properties of wool. Textile Res. J., 41, 605–609.

    CAS  Google Scholar 

  9. Friedman, M., and Romersberger, J. S. (1968). Relative influences of electron-withdrawing functional groups on basicities of amino acid derivatives. J. Org. Chem., 33, 154–157.

    Google Scholar 

  10. Friedman, M., and Wall, J. W. (1964). Application of a Hammett-Taft relation to kinetics of alkylation of amino acid and peptide model compounds with acrylonitrile. J. Am. Chem. Soc., 86, 3735–3741.

    Article  CAS  Google Scholar 

  11. Friedman, M., Cavins, J. F., and Wall, J. S. (1965). Relative nucleophilic reactivities of amino groups and mercaptide ions in addition reactions with a, (3-unsaturated compounds. J. Am. Chem. Soc., 87, 3572–3682.

    Google Scholar 

  12. Koenig, N. H., Muir, M. W., and Friedman, M. (1973). Properties of wool modified with vinyl compounds. Textile Res. J., 43, 682–688.

    CAS  Google Scholar 

  13. Riggs, N. V. (1958). Kinetic treatment of two-stage second-order consecutive reactions with a common factor. Aust. J. Chem., 11, 86–92.

    Article  CAS  Google Scholar 

  14. Snow, J. T., Finley, J. W., and Friedman, M. (1975). Relative reactivities of sulfhydryl groups with N-acetyldehydroalanine and N-acetyldehydroalanine methyl ester. Int. J. Peptide Protein Res., 7, 461–466.

    Article  CAS  Google Scholar 

  15. Szabo, Z. G. (1969). Kinetic characterization of complex reaction systems. In “Chemical Kinetics,” Chapter 1, C. H. Bamford and C. F. H. Tipper (Editors), Elsevier, Amsterdam, Holland.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Springer Science+Business Media New York

About this chapter

Cite this chapter

Friedman, M., Williams, L.D. (1977). A Mathematical Analysis of Kinetics of Consecutive, Competitive Reactions of Protein Amino Groups. In: Friedman, M. (eds) Protein Crosslinking. Advances in Experimental Medicine and Biology, vol 86. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9113-6_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9113-6_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9115-0

  • Online ISBN: 978-1-4757-9113-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics