Skip to main content
SpringerLink
Log in

Comparative Structure and Function of Mammalian Zonae Pellucidae

  • Chapter
A Comparative Overview of Mammalian Fertilization

Abstract

The process of fertilization, like other aspects of mammalian reproduction, varies markedly among different species. Of the many complex events that accompany this process, the interaction between the sperm and the zona pellucida (ZP) is one of the most significant. The mammalian ZP is an extracellular glycoprotein structure that is formed around the oocyte during the early stages of ovarian follicular development. This matrix is important in the initial stages of fertilization because the sperm must bind to and penetrate it before fusing with the oocyte plasma membrane (Austin and Braden, 1956; Austin, 1975). The ZP is also involved in the block to polyspermy in many species and further serves to protect the embryo after fertilization until implantation in the uterine wall. Species differences have been reported for several steps in the fertilization process, including sperm capacitation (the changes spermatozoa undergo in the female reproductive tract in order to develop the capacity to fertilize the egg) and sperm binding to and penetration of the ZP. Many of these differences can be attributed to morphological and biochemical variations of the gametes themselves (Yanagimachi, 1977; Bedford, 1974; other chapters in this text).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahuja, K. K., and Botwell, G. P.,1983, Probable asymmetry in the organization of components of the hamster zona pellucida, J. Reprod. Fertil. 69: 49–55.

    Google Scholar 

  • Aketa, K.,1973, Physiological studies on the egg surfaces component responsible for sperm—egg binding in sea urchin fertilization. I. Effect of sperm-binding protein on the fertilizing capacity of sperm, Exp. Cell. Res. 70: 439–441.

    Google Scholar 

  • Austin, C. R., 1961, The Mammalian Egg, Springfield, IL: Charles C. Thomas.

    Google Scholar 

  • Austin, C. R., 1965, Fertilization, Prentice-Hall, Englewood Cliffs, NJ.

    Google Scholar 

  • Austin, C. R., 1975, Membrane fusion events in fertilization, J. Reprod. Fertil. 44: 155–166.

    PubMed  CAS  Google Scholar 

  • Austin, C. R., and Braden, A. W. H., 1956, Early reactions of the rodent egg to spermatozoa penetration, J. Exp. Biol. 33: 358–365.

    Google Scholar 

  • Austin, C. R., and Short, R. V, eds., 1982, Reproduction in Mammals: Germ Cells and Fertilization, Cambridge University Press, Cambridge.

    Google Scholar 

  • Baranska, W., Konwinski, M., and Kujawa, M., 1974, Fine structure of the zona pellucida of unfertilized egg cells and embryos, J. Exp. Zool. 192: 193–202.

    Google Scholar 

  • Baranska, W., Konwinski, M., and Kujawa, M., 1975, Fine structure of the zona pellucida of unfertilized egg cells and embryos, J. Exp. Zool. 192: 193–202.

    PubMed  CAS  Google Scholar 

  • Barros, C., and Yanagimachi, R., 1971, Induction of zona reaction in golden hamster eggs by cortical granule material, Nature 233: 268–269.

    PubMed  CAS  Google Scholar 

  • Bedford, J. M., 1974, Mechanisms involved in penetration of spermatozoa through the vestments of the mammalian egg, in: Physiology and Genetics of Reproduction, Part B ( E. M. Coutino and F. Fuch, eds.), Plenum Press, New York, pp. 55–68.

    Google Scholar 

  • Bedford, J. M., 1977, Sperm/egg interaction: The specificity of human spermatozoa, Anat. Rec. 188: 477–488.

    PubMed  CAS  Google Scholar 

  • Bedford, J. M., and Cross, N. L., 1978, Normal penetration of rabbit spermatozoa through a trypsin-and acrosinresistant zona pellucida, J. Reprod. Fertil. 54: 385–392.

    PubMed  CAS  Google Scholar 

  • Bleil, J. D., and Wassarman, P., 1980a, Mammalian sperm-egg interaction: Identification of a glycoprotein in mouse egg zonae pellucidae possessing receptor activity for sperm, Cell 20: 873–882.

    PubMed  CAS  Google Scholar 

  • Bleil, J. D., and Wassarman, P M., 1980b, Synthesis of zona pellucida proteins by denuded and follicle-enclosed mouse oocytes during culture in vitro, Proc. Natl. Acad. Sci. U.S.A. 77: 1029–1033.

    PubMed  CAS  Google Scholar 

  • Bleil, J. D., and Wassarman, P M., 1988, Galactose at the nonreducing terminus of 0-linked oligosaccharides of mouse egg zona pellucida glycoprotein ZP3 is essential for the glycoprotein’s sperm receptor activity, Proc. Natl. Acad. Sci. U.S.A. 85: 6778.

    PubMed  CAS  Google Scholar 

  • Bousquet, D., Leveille, M. C., Roberts, K. D., Chapdelaine, A., and Bleau, G., 1981, The cellular origin of the zona pellucida antigen in the human and hamster, J. Exp. Zool. 215: 215–218.

    PubMed  CAS  Google Scholar 

  • Braden, A. W H., and Austin, C. R., 1954, The number of sperm about the eggs in mammals and its significance for normal fertilization, Aust. J. Biol. Sci. 7: 543–551.

    PubMed  CAS  Google Scholar 

  • Braden, A. W H., Austin, C. R., and David, H. A., 1954, The reaction of zona pellucida to sperm penetration, Aust. J. Biol. Sci. 7: 391–409.

    PubMed  CAS  Google Scholar 

  • Brown, C. R., 1982, Effects of ram sperm acrosin on the investments of sheep, pig, mouse, and gerbil eggs, J. Reprod. Fertil. 64: 457–462.

    PubMed  CAS  Google Scholar 

  • Brown, C. R., 1974, Distribution of trypsin-like proteinase in the ram spermatozoa, J. Reprod. Fertil. 36: 195–198.

    PubMed  CAS  Google Scholar 

  • Centola, G. M., 1983, Structural changes: Follicular development and hormonal requirements, in Comprehensive Endocrinology: The Ovary ( G. B. Serra, (ed.), Raven Press, New York, p. 95.

    Google Scholar 

  • Chamberlain, M. E., and Dean, J. 1989, Genomic organization of a sex specific gene: The primary sperm receptor of the mouse zona pellucida, Dev. Biol. 131: 207–214.

    Google Scholar 

  • Chiquoine, A. D., 1960, The development of the zona pellucida of the mammalian ovum, Am. J. Anat. 106: 149–169.

    PubMed  CAS  Google Scholar 

  • Cholewa-Stewart, J., and Massaro, E. J., 1972, Thermally induced dissolution of the mutine zona pellucida, Biol. Reprod. 7: 166–169.

    PubMed  CAS  Google Scholar 

  • Dickmann, Z., and Dziuk, P. J., 1964, Sperm penetration of the zona pellucida of the pig egg, J. Exp. Biol. 41:603–608. Drell, D. M., and Dunbar, B. S., 1984, Monoclonal antibodies to rabbit and pig zonae pellucidae distinguish species-specific and shared antigenic determinants, Biol. Reprod. 30: 445.

    Google Scholar 

  • Drell, D. W, Wood, D. M., Bundman, D. S., and Dunbar, B. S., 1984, Immunological comparison of antibodies to porcine zone pellucidae in rats and rabbits, Biol. Reprod. 30: 435–444.

    Google Scholar 

  • Dunbar, B. S., 1980, Model systems to study the relationship between antibodies to zonae and infertility: Comparison to rabbit and porcine zonae pellucidae. Ninth International Congress on Animal Reproduction and Artificial Insemination II, Spanish Ministry of Agriculture, Madrid, Spain, pp. 191–199.

    Google Scholar 

  • Dunbar, B. S., 1983, Morphological, biochemical, and immunochemical characterization of the mammalian zonae pellucidae, in: Mechanism and Control of Animal Fertilization ( J. Hartmann, ed.), Academic Press, New York, pp. 139–175.

    Google Scholar 

  • Dunbar, B. S., 1989, Ovarian antigens and infertility, Am. J. Reprod. Immunol. 21:28–31.

    Google Scholar 

  • Dunbar, B. S., and Wolgemuth, D. J., 1984, Structure and function of the mammalian zona pellucida, a unique extracelllular matrix, in: Modern Cell Biology ( B. Satir, ed.), Alan R. Liss, New York, pp. 77–111.

    Google Scholar 

  • Dunbar, B. S., Wardrip, N. J., and Hedrick, J. L., 1980, Isolation, physicochemical properties and macromolecular composition of zona pellucida from porcine oocytes, Biochemistry 19: 356.

    PubMed  CAS  Google Scholar 

  • Dunbar, B. S., Liu, C., and Sammons, D. W., 1981, Identification of the three major proteins of porcine and rabbit zonae pellucidae by high resolution two-dimensional gel electrophoresis: Comparison with follicular fluid, sera, and ovarian cell proteins, Biol. Reprod. 24: 1111–1124.

    PubMed  CAS  Google Scholar 

  • Dunbar, B. S., Dudkiewicz, A., and Bundman, D. S., 1985, Proteolysis of specific porcine zona pellucida glycoproteins by boar acrosin, Biol. Reprod. 32: 619–630.

    PubMed  CAS  Google Scholar 

  • Dutt, A., Tang, J.-P., and Carson, D. D., 1987, Lactosaminoglycans are involved in uterine epithelial cell adhesion in vitro, Dew. Biol. 119: 27–37.

    CAS  Google Scholar 

  • Flechon, J. E., Pavlok, A., and Kopecny, V., 1974, Dynamics of zona pellucida formation by the mouse oocyte. An autoradiographic study, Biol. Cell 51: 403–406.

    Google Scholar 

  • Florman, H..M., and Wassarman, P. M., 1985, 0-Linked oligosaccharides of mouse egg ZP3 account for its sperm receptor activity, Cell 41: 313.

    Google Scholar 

  • Fukuda, M., 1985, Cell surface glycoconjugates as onco-differentiation markers in hematopoietic cells, Biochim. Biophys. Acta 780: 119–150.

    PubMed  CAS  Google Scholar 

  • Fukuda, M. N., and Matsumura, G., 1976, Purification and endoglycosidic action on keratan sulfates, oligosaccharides, and blood group active glycoprotein, J. Biol. Chem. 251: 6218–6225.

    PubMed  CAS  Google Scholar 

  • Greve, L. C., and Hedrick, J. L., 1978, An immunocytochemical localization of the cortical granule lectin in fertilized and unfertilized eggs of Xenopus laevis, Gamete Res. 1: 13–18.

    CAS  Google Scholar 

  • Greve, J. J., Salzman, G. S., Roller, R. J., and Wassarman, P. M., 1982, Biosynthesis of the major zona pellucida glycoprotein secreted by oocytes during mammalian oogenesis, Cell 31: 749–759.

    PubMed  CAS  Google Scholar 

  • Grey, R. D., Working, P. K., and Hedrick, J. L., 1976, Evidence that the fertilization envelope blocks sperm entry in eggs of Zenopus laevis: Interaction of sperm with isolated envelopes, Dev. Biol. 54: 52–60.

    PubMed  CAS  Google Scholar 

  • Guraya, S. S., 1974, Morphology, histochemistry, and biochemistry of human oogenesis and ovulation, in: International Review of Cytology ( G. H. Bourne and J. F. Danielli, eds.), Academic Press, New York, pp. 121–151.

    Google Scholar 

  • Gwatkin, R. B. L., and Williams, D. T., 1977, Receptor activity of the hamster and mouse solubilized zona pellucida before and after the zona reaction, J. Reprod. Fertil. 49: 55–59.

    PubMed  CAS  Google Scholar 

  • Gwatkin, R. B. L., Williams, D. T., Hartmann, J. E, and Kniazuk, M., 1973, The zona reaction of hamster and mouse eggs: Production in vitro by a trypsin-like protease from cortical granules, J. Reprod. Fertil. 32: 259–265.

    PubMed  CAS  Google Scholar 

  • Haddad, A., and Nagai, M. E. T., 1977, Radioautographic study of glycoprotein biosynthesis and renewal in the ovarian follicles of mice and the origin of the zona pellucida, Cell Tissue Res. 177: 347–369.

    PubMed  CAS  Google Scholar 

  • Hakomori, S., 1981, Glycosphingolipids in cellular interaction, differentiation, and oncogenesis, Annu. Rev. Biochem. 50: 733–764.

    PubMed  CAS  Google Scholar 

  • Hartmann, J. F., and Hutchison, C. E., 1974, Nature of the pre-penetration contact interaction between hamster gametes in vitro, J. Reprod. Fertil. 36: 49–57.

    PubMed  CAS  Google Scholar 

  • Hartmann, J. F, and Hutchison, C. F, 1977, Involvement of two carbohydrate-containing components in the binding of uncapacitated spermatozoa to eggs of the golden hamster in vitro, J. Exp. Zool. 201: 383–390.

    PubMed  CAS  Google Scholar 

  • Hedrick, J. L., and Frye, G. N., 1980, Immunocytochemical studies on the porcine zona pellucida, J. Cell Biol. 87: 136a.

    Google Scholar 

  • Hedrick, J. L., and Wardrip, N. J., 1987, On the macromolecular composition of the zona pellucida from porcine oocytes, Dey. Biol. 121: 478–488.

    CAS  Google Scholar 

  • Inoue, M., and Wolf, D. P, 1975, Comparative solubility properties of rat and hamster zonae pellucidae, Biol. Reprod. 12: 535–540.

    CAS  Google Scholar 

  • Jones, R. E., 1978, The Vertebrate Ovary, Plenum Press, New York.

    Google Scholar 

  • Kang, Y. H., 1974, Development of the zona pellucida in the rat oocyte, Am. J. Anat. 139: 535–566.

    PubMed  CAS  Google Scholar 

  • Karp, D. R., Atkinson, J. P, and Shreffler, D. C., 1982, Genetic variation in glycosylation of the fourth component of murine complement, J. Biol. Chem. 257: 7330–7335.

    PubMed  CAS  Google Scholar 

  • Kinloch, R. A., Roller, R. J., Fimiani, C. M., Wassarman, D. A., and Wassarman, P. M., 1988, Primary structure of the mouse sperm receptor polypeptide determined by genomic cloning, Proc. Natl. Acad. Sci. U.S.A. 85: 6409–6413.

    PubMed  CAS  Google Scholar 

  • Kinsey, W. H., and Lennarz, W. J., 1981, Isolation of a glycopeptide fraction from surface of the sea urchin egg that inhibits sperm-egg binding and fertilization, J. Cell Biol. 91: 325–331.

    PubMed  CAS  Google Scholar 

  • Konecny, M., 1959, Etude histochimique de la zone pellucide des ovules de chatte, C.R. Soc. Biol. 153: 893–894.

    CAS  Google Scholar 

  • Leveille, M. C., Roberts, K. D., Chevalier, S., Chapdelaine, A., and Bleau, G., 1987, Formation of the hamster zona pellucida in relation to ovarian differentiation and follicular growth, J. Reprod. Fertil. 79: 173–183.

    PubMed  CAS  Google Scholar 

  • Liang, L.-F., Chamow, S. M., and Dean, J., 1990, Oocyte-specific expression of mouse ZP2: Developmental regulation of the zona pellucida genes, Mol. Cell Biol. 10: 1507–1515.

    PubMed  CAS  Google Scholar 

  • Lunsford, R. D., Jenkins, N. A., Kozak, C. A., Liang, L.-F., Silan, C. M., Copeland, N. G., and Dean, J., 1990, Genomic mapping of murine ZP-2 and ZP-3, two oocyte-specific loci encoding zona pellucida proteins, Genomics 6: 184–187.

    PubMed  CAS  Google Scholar 

  • Macek, M. B., and Shur, B. D., 1988, Protein-carbohydrate complementarity in mammalian gamete recognition, Gamete Res. 20: 93–102.

    PubMed  CAS  Google Scholar 

  • Maresh, G. A., and Dunbar, B. S., 1987, Antigenic comparison of five species of zone pellucidae, J. Exp. Zool. 244: 299–307.

    PubMed  CAS  Google Scholar 

  • Maresh, G. A., Timmons, T. M., and Dunbar, B. S., 1990, Effects of extracellular matrix on the expression of specific ovarian proteins, Biol. Reprod. 43: 965–976.

    PubMed  CAS  Google Scholar 

  • Martinek, J., and Krausova, H., 1972, Development of the zona pellucida in the rat, Fol. Morphol. 20: 73–75.

    CAS  Google Scholar 

  • McCulloh, D., Wall, R. J., and Levitan, H., 1987, Fertilization of rabbit ova and the role of ovum investments in the block to polyspermy, Dev. Biol. 120: 385–391.

    PubMed  CAS  Google Scholar 

  • McRorie, R. A., and Williams, W. L., 1974, Biochemistry of mammalian fertilization, Annu. Rev. Biochem. 43: 777–801.

    PubMed  CAS  Google Scholar 

  • Meizel, S., and Liu, C. W, 1976, Evidence for a role of a trypsin-like enzyme in the hamster acrosome reaction, J. Exp. Zool. 195: 137–144.

    PubMed  CAS  Google Scholar 

  • Merker, H. J., 1961, Electronmikroskopishce untersuchungen uber die bildung der zona pellucida in den follikeln des kaninchenovars, Z. Zellforsch. 65: 677–688.

    Google Scholar 

  • Millar, S. E., Chamon, S. M., Baur, A. W, Oliver, C., Robey, F., and Dean, J., 1989, Vaccination with a synthetic zona pellucida peptide produces long-term contraception in female mice, Science 246: 935–938.

    PubMed  CAS  Google Scholar 

  • Moller, C. C., Bleil, J. D., Kinloch, R. A., and Wassarman, P. M., 1990, Structural and functional relationships between mouse and hamster zona pellucida glycoproteins, Dev. Biol. 137: 276–286.

    PubMed  CAS  Google Scholar 

  • Moore, H. D. M., and Bedford, J., 1983, The interaction of mammalian gametes in the female, in: Mechanism and Control of Animal Fertilization ( J. Hartmann, ed.), Academic Press, New York, pp. 453–497.

    Google Scholar 

  • Odor, D. L., 1960, Electron microscope studies on the ovarian oocytes and unfertilized tubal ova in the rat, J. Biophys. Biochem. Cytol. 7: 567–574.

    PubMed  CAS  Google Scholar 

  • Oikawa, T., Sendai, Y., Kurata, S., and Yanagimachi, R., 1988, A glycoprotein of oviductal origin alters biochemical properties of the zona pellucida of hamster egg, Gamete Res. 19: 113–122.

    PubMed  CAS  Google Scholar 

  • Peters, H., and McNatty, K. P, 1980, The Ovary: A Correlation of Structure and Function in Mammals, University of California Press, Berkeley.

    Google Scholar 

  • Peterson, R. N., Russell, L. D., Bundman, D., and Freund, M., 1980, Sperm-egg interaction: Evidence for boar sperm plasma membrane receptors for porcine zona pellucida, Science 207: 73–74.

    PubMed  CAS  Google Scholar 

  • Peterson, R. N., Russell, L. D., Bundman, D., Conway, M., and Freund, M., 1981, The interaction of living boar sperm and sperm plasma membrane vesicles with the porcine zona pellucida, Dev. Biol. 84: 144–156.

    PubMed  CAS  Google Scholar 

  • Phillips, D. M., and Shalgi, R. M., 1980, Surface properties of the zona pellucida, J. Exp. Zool. 213: 1–8.

    PubMed  CAS  Google Scholar 

  • Philpott, C. C., Ringuette, M. J., and Dean, J., 1987, Oocyte-specific expression and developmental regulation of ZP3, the sperm receptor of the mouse zona pellucida, Dev. Biol. 121: 568–575.

    Google Scholar 

  • Polakoski, K. L., and McRorie, R. A., 1973, Boar acrosin. II. Classification, inhibition, and specificity studies of a proteinase from sperm acrosomes, J. Biol. Chem. 248: 8183–8188.

    PubMed  CAS  Google Scholar 

  • Reid, L. M., and Jefferson, D. M., 1984, Cell culture studies using extracts of extracellular matrix to study growth and differentiation in mammalian cells, in: Mammalian Cell Culture ( J. Mathur, ed.), Plenum Press, New York, p. 239.

    Google Scholar 

  • Ringuette, M. J., and Sobieski, D. A., Chamow, S. M., and Dean, J., 1986, Oocyte-specific gene expression: molecular characterization of a eDNA coding for ZP-3, the sperm receptor of the mouse zona pellucida, Proc. Natl. Acad. Sci. U.S.A. 83: 4341–4345.

    CAS  Google Scholar 

  • Ringuette, M. J., Chamberlain, M. E., Baur, A. W., Sobieski, D. A., and Dean, J., 1988, Molecular analysis of cDNA coding for ZP3, a sperm binding protein of the mouse zona pellucida, Dev. Biol. 127: 287–295.

    PubMed  CAS  Google Scholar 

  • Rolland, R., Van Hall, E. V., Hillier, S. G., McNatty, K. P., and Schoemaker, J., eds., 1982, Follicular Maturation and Ovulation, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Ruiz-Bravo, N., and Lennarz, W. J., 1989, Receptors and membrane interactions in fertilization, in: The Molecular Biology of Fertilization ( H. Schatter and G. Schatter, eds.), Academic Press, San Diego, pp. 21–36.

    Google Scholar 

  • Sacco, A. G., 1981, Immunocontraception: Consideration of the zona pellucida as a target antigen, Obstet. Gynecol. 10: 1–26.

    CAS  Google Scholar 

  • Sacco, A. G., Yurewicz, E. C., Subramanian, M. G., and DeMayo, F. J., 1981, Zona pellucida composition: Species crossreactivity and contraceptive potential of antiserum to a purified peg zona antigen (PPZA), Biol. Reprod. 25: 997–1008.

    PubMed  CAS  Google Scholar 

  • Saling, P. M., Storey, B. T., and Wolf, D. P., 1978, Calcium-dependent binding of mouse epididymal spermatozoa to the zona pellucida, Dev. Biol. 65: 515–525.

    PubMed  CAS  Google Scholar 

  • Salzmann, G. S., Greve, J. M., Roller, R. J., and Wassarman, P. M., 1983, Biosynthesis of the sperm receptor during oogenesis in the mouse, EMBO J. 2: 1451–1456.

    PubMed  CAS  Google Scholar 

  • Sasaki, H., Bothner, B., Dell, A., and Fukuda, M., 1987, Carbohydrate structure of erythropoietin expressed in Chinese hamster ovary cells by a human erythropoietin cDNA, J. Biol. Chem. 262: 12059–12076.

    PubMed  CAS  Google Scholar 

  • Schleuning, M. D., Schiessler, H., and Fritz, H., 1973, Highly purified acrosomal proteinase (boar acrosin): Isolation by affinity chromatography using benzamidine-cellulose and stabilization, Hoppe-Seylers Z. Physiol. Chem. 354: 550–554.

    PubMed  CAS  Google Scholar 

  • Schmell, E. D., Gulyas, B. J., and Hedrick, J. L., 1983, Egg surface changes during fertilization and the molecular mechanism of the block to polyspermy, in: Mechanism and Control of Animal Fertilization ( J. Hartmann, ed.), Academic Press, New York, pp. 365–503.

    Google Scholar 

  • Schwoebel, E., Prasad, S., Timmons, T., Cook, R., Kimura, H., Niu, E., Cheung, E, Skinner, S., Avery, S., Wilkins, B., and Dunbar, B., 1991, Isolation and characterization of a full length cDNA encoding the 55K rabbit ZP protein, J. Biol. Chem. 266: 7214–7219.

    PubMed  CAS  Google Scholar 

  • Shabanowitz, R. B., and O’Rand, M. G., 1988, Characterization of the human zona pellucida from fertilized and unfertilized eggs, J. Reprod. Fertil. 82: 151–161.

    PubMed  CAS  Google Scholar 

  • Shabanowitz, R. B., I. O’Rand, M. G., 1989, Molecular changes in the human zona pellucida associated with fertilization and human sperm-zona interactions, Ann. N. Y. Acad. Sci. 541: 621–623.

    Google Scholar 

  • Shimizu, S., Tsuji, M., and Dean, J., 1983, In vitro biosynthesis of three sulfated glycoproteins of murine zonae pellucidae by oocytes grown in follicle culture, J. Biol. Chem. 258: 5858–5863.

    CAS  Google Scholar 

  • Shur, B. D., and Hall, N. G., 1982, A role for mouse sperm galactosyltransferase in sperm binding to the egg zona pellucida, J. Cell Biol. 95: 574–579.

    PubMed  CAS  Google Scholar 

  • Skinner, S. M., and Dunbar, B. S., 1986, Species variation in the zona pellucida, in: Immunological Approaches to Contraception and Promotion of Fertility ( G. P Talwar, ed.), Plenum Press, New York, pp. 251–268.

    Google Scholar 

  • Skinner, S. M., Timmons, T. M., Schwoebel, E. D., and Dunbar, B. S., 1990, The role of zona pellucida antigens in fertility and infertility, Immunol. Allergy Clin. North Am. 10: 185–197.

    Google Scholar 

  • Schmell, E. D., and Gulyas, B. J., 1980, Mammalian sperm-egg recognition and binding in vitro. Specificity of sperm interactions with live and fixed eggs in homologous and heterologous inseminations of hamster, mouse, and guinea pig oocytes, Biol. Reprod. 23: 1075–1085.

    PubMed  CAS  Google Scholar 

  • Srivastava, P. N., Adams, C. E., and Hartree, E. F., 1965, Enzymic action of acrosomal preparation on the rabbit ovum in vitro, J. Reprod. Fertil. 10: 61–67.

    PubMed  CAS  Google Scholar 

  • Stambaugh, R., 1978, Enzymatic and morphological events in mammalian fertilization, Gamete Res. 1: 65–85.

    CAS  Google Scholar 

  • Stambaugh, R., and Buckley, J., 1969, Identification and subcellular localization of the enzymes effecting penetration of the zona pellucida by rabbit spermatozoa, J. Reprod. Fertil. 19: 423–432.

    PubMed  CAS  Google Scholar 

  • Stegner, H. E., and Wartenberg, H., 1961, Elektronenmikroskopische und histochemische Untersuchen uber Struktur und Bildung der Zona pellucida menshlicher lin Zellen, Z. Zellforsch. Mikrosk. Anat. 53: 702–713.

    Google Scholar 

  • Swenson, C. E., and Dunbar, B. S., 1982, Specificity of sperm—zona interaction, J. Exp. Zool. 219: 97–104.

    PubMed  CAS  Google Scholar 

  • Tesoriero, J. V, 1984, Comparative cytochemistry of the developing ovarian follicles of the dog, rabbit and mouse: Origin of the zona pellucida, Gamete Res. 10: 301–318.

    Google Scholar 

  • Timmons, T. M., and Dunbar, B. S., 1988, Antigens of mammalian zona pellucida, in: Perspectives in Immunoreproduction: Conception and Contraception ( S. Mathur and C. M. Fredericks, eds.), Hemisphere, New York, pp. 242–260.

    Google Scholar 

  • Timmons, T. M., and Dunbar, B. S., 1990a, Analysis of the structure and function of a carbohydrate antigen of the mammalian zonae pellucidae, J. Cell Biol. 111 (5, Pt. 2): 365a.

    Google Scholar 

  • Timmons, T M., and Dunbar, B. S., 1990b, Glycosylation and maturation of the mammalian zona pellucida, in: Gamete Interaction: Prospects for Immunocontraception ( N. Alexander, D. Griffin, G. Waites, and J. Spieler, eds.), John Wiley and Sons, Inc., New York, pp. 277–292.

    Google Scholar 

  • Timmons, T. M., Maresh, G. A., Bundman, D. S., and Dunbar, B. S., 1987, Use of specific monoclonal and polyclonal antibodies to define distinct antigens of the porcine zonae pellucidae, Biol. Reprod. 36: 1275–1287.

    PubMed  CAS  Google Scholar 

  • Topfer-Petersen, E., and Henschen, A., 1987, Acrosin shows zona and fucose binding, novel properties for a serine protease, FEBS Lett. 226: 38–42.

    PubMed  CAS  Google Scholar 

  • Topfer-Petersen, E., and Henschen, A., 1988, Zona pellucida-binding and fucose-binding of boar sperm acrosin is not correlated with proteolytic activity, Hoppe-Seylers Z. Physiol Chem. 369: 69–76.

    CAS  Google Scholar 

  • Trujillo-Cenoz, O., and Sotelo, J. R., 1959, Relationships of the ovular surface with follicle cells and origin of the zona pellucida in rabbit oocytes, J. Biophys. Biochem. Cytol. 5: 347–348.

    PubMed  CAS  Google Scholar 

  • Wartenberg, H., and Stegner, H. E., 1960, Uber die elektronenmikroshopische Feinstruktur des menschlichen Ovarialeies, Z. Zellforsch. 52: 450–474.

    PubMed  CAS  Google Scholar 

  • Wassarman, P. M., 1988, Zona pellucida glycoproteins, Annu. Rev. Biochem. 57: 415–522.

    PubMed  CAS  Google Scholar 

  • Wolf, D. P, 1981, The mammalian eggs’ block to polyspermy, in: Fertilization and Embryonic Development in Vitro ( L. Mastroianni, Jr., and J. D. Biggers, eds.), Plenum Press, New York, pp. 183–197.

    Google Scholar 

  • Wolgemuth, D. J., Celenza, J., Bundman, D. S., and Dunbar, B. S., 1984, Formation of the rabbit zona pellucida and its relationship to ovarian follicular development, Dev. Biol. 106: 1–14.

    PubMed  CAS  Google Scholar 

  • Wright, R. W., Jr., Cupps, P. T., Goskins, C. T., and Hillers, J. K., 1977, Comparative solubility properties of the zona pellucida of unfertilized murine, ovine, and bovine ova, J. Anim. Sci. 44: 850–853.

    PubMed  Google Scholar 

  • Yanagimachi, R., 1977, Specificity of sperm-egg interaction, in: Immunobiology of Gametes ( M. Edidin and M. H. Johnson, eds.), Cambridge University Press, London, pp. 187–207.

    Google Scholar 

  • Yoshima, H., Matsumoto, A., Mizuochi, T., Kawasaki, T., and Kobata, A., 1981, Comparative study of the carbohydrate moieties of rat and human plasma alpha(1)-acid glycoproteins, J. Biol. Chem. 256: 8476–8482.

    PubMed  CAS  Google Scholar 

  • Yurewicz, E. C., Sacco, A. G., and Subramanian, M. G., 1987, Structural characterization of the M r = 55,000 antigen (ZP3) of porcine oocyte zona pellucida, J. Biol. Chem. 262: 564–571.

    PubMed  CAS  Google Scholar 

  • Zamboni, L., and Mastroianni, L., 1966, Electron microscopic studies on rabbit ova. I. The follicular oocyte, J. Ultrastruct. Res. 14: 95–117.

    Google Scholar 

  • Zaneveld, L. J. D., Robertson, R. T., Kessler, M., and Williams, W. L., 1971, Inhibition of fertilization in vivo by pancreatic and seminal plasma trypsin inhibitors, J. Reprod. Fertil. 25: 387–392.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA

    Bonnie S. Dunbar, S. V. Prasad & T. M. Timmons

Authors
  1. Bonnie S. Dunbar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. V. Prasad
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. M. Timmons
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Cell Biology, Baylor College of Medicine, 77030, Houston, Texas, USA

    Bonnie S. Dunbar

  2. Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, North Carolina, USA

    Michael G. O’Rand

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Dunbar, B.S., Prasad, S.V., Timmons, T.M. (1991). Comparative Structure and Function of Mammalian Zonae Pellucidae. In: Dunbar, B.S., O’Rand, M.G. (eds) A Comparative Overview of Mammalian Fertilization. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-8982-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-8982-9_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-8984-3

  • Online ISBN: 978-1-4757-8982-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation