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The Kidney and Hypertension in Diabetes Mellitus pp 113–122Cite as

Genetics and Diabetic Nephropathy

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Abstract

Both genetic determinants and environmental conditions can affect enzyme activity. As all IDDM complications are secondary to long lasting hyperglycemia, the search for a genetic basis to diabetic nephropathy represents a typical example of search for gene-environment interaction. Furthermore, gene-gene interactions must be expected, as determinants for IDDM complications are multifactorial. Lastly, the level of evidence for one given gene polymorphism is currently low to account for diabetic nephropathy. Thus, practical implications for this type of investigation in patient care are currently premature.

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  1. Centre Hospitalier Universitaire, Angers, France

    Michel Marre & Béatrice Bouhanick

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  1. Michel Marre
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  2. Béatrice Bouhanick
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  1. Medical Department M (Diabetes & Endocrinology), Aarhus Kommunehospital, Aarhus University Hospital, Aarhus C, Denmark

    Carl Erik Mogensen

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Marre, M., Bouhanick, B. (1998). Genetics and Diabetic Nephropathy. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6752-0_12

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  • DOI: https://doi.org/10.1007/978-1-4757-6752-0_12

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