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The Kidney and Hypertension in Diabetes Mellitus pp 253–261Cite as

Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors

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Abstract

Glomerular hyperfiltration in insulin-dependent (Type 1) diabetes mellitus of short duration has been recognized for many years [1–3], with increments in renal plasma flow (RPF) and nephromegaly [3]. With the finding of early hyperfiltration, Stalder and Schmid proposed that these early functional changes may predispose the subsequent development of diabetic glomerulopathy [1]. Early support for the hypothesis that renal hyperperfusion and hyperfiltration contribute to diabetic glomerulopathy emanated from the finding of diabetic glomerulopathy only in the non-stenosed kidney in the setting of unilateral renal artery stenosis [4].

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Authors and Affiliations

  1. Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland, OR, USA

    Sharon Anderson

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Editors and Affiliations

  1. Medical Department M (Diabetes & Endocrinology), Aarhus Kommunehospital University Hospitals in Aarhus, Aarhus C, Denmark

    Carl Erik Mogensen

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Anderson, S. (1996). Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6749-0_26

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  • DOI: https://doi.org/10.1007/978-1-4757-6749-0_26

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