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Biochemical Aspects of Diabetic Nephropathy

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The Kidney and Hypertension in Diabetes Mellitus

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Abstract

The dominant histological feature of diabetic nephropathy is the thickening of the glomerular basement membrane and expansion of the mesangial matrix [1–3]. The changes correlate strongly with the clinical onset of proteinuria, hypertension and kidney failure. Although more than 50 years have elapsed since Kimmelstiel and Wilson [4] described in diabetic glomeruli the distinctive periodic acid-schiff (PAS)-reactive nodular deposits, progress in elucidating the pathobiochemistry has been slow. Recent investigations with electron microscopic, immunochemical and biochemical methods have led to an improved understanding of the structure-function relationship of the glomerular filtration unit in normal and pathological conditions [5].

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Authors and Affiliations

  1. Institut für Diabetesforschung, München, Germany

    Erwin D. Schleicher

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  1. Erwin D. Schleicher
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Editors and Affiliations

  1. Medical Department M (Diabetes & Endocrinology), Aarhus Kommunehospital University Hospitals in Aarhus, Aarhus C, Denmark

    Carl Erik Mogensen

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Schleicher, E.D. (1996). Biochemical Aspects of Diabetic Nephropathy. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6749-0_23

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  • DOI: https://doi.org/10.1007/978-1-4757-6749-0_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6751-3

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