Skip to main content
SpringerLink
Log in

Incidence of Nephropathy in Insulin-Dependent Diabetes Mellitus as Related to Mortality and Cost-Benefit of Early Intervention

  • Chapter
The Kidney and Hypertension in Diabetes Mellitus

  • 64 Accesses

Abstract

Development of clinical diabetic nephropathy in IDDM-patients is associated with high excess mortality as well as with generalized vascular lesions and impairment in the cardiovascular risk profile of the individual. It therefore indicates a poor prognosis of the patient.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Borch-Johnsen K: The prognosis of insulin-dependent diabetes mellitus. Dan Med Bull 1989; 36: 336–348.

    PubMed  CAS  Google Scholar 

  2. Diabetes Epidemiology Research International (DERI) Mortality Study Group: Major Cross-Country differences in risk of dying for people with IDDM. Diabetes Care 1991; 14: 49–54.

    Article  Google Scholar 

  3. Watson PJ, Blainey JD, Brewer DB, Fitzgerald MG, Malins JM, O’Sullivan DJ, Pinto JA: The natural history of diabetic renal disease. Q J Med 1972; 164: 437–456.

    Google Scholar 

  4. Borch-Johnsen K, Andersen PK, Deckert T: The effect of proteinuria on relative mortality in Type 1 (insulin-dependent) diabetes mellitus. Diabeto logia 1985; 28: 590–596.

    CAS  Google Scholar 

  5. Borch-Johnsen K, Kreiner S, Deckert T: Mortality of Type 1 (insulin-dependent) diabetes mellitus in Denmark. Diabetologia 1986; 29: 767–772.

    Article  PubMed  CAS  Google Scholar 

  6. Kofoed-Enevoldsen A, Borch-Johnsen K, Kreiner S, Nerup J, Deckert T: Declining incidence of persistent proteinuria in Type 1 (insulin-dependent)diabetic patients in Denmark. Diabetes 1987; 36: 205–209.

    Article  PubMed  CAS  Google Scholar 

  7. Krolewski AS, Warram JH, Christlieb ARE, Busick EJ, Kahn CR: The changing natural history of nephropathy in Type 1 diabetes. Am J Med 1985; 78: 785–794.

    Article  PubMed  CAS  Google Scholar 

  8. Viberti GC, Jarrett RJ, Mahmud U, Hill RD, Argyropoulos A, Keen H: Microalbuminuria as a predictor of clinical nephropathy in insulin dependent diabetes mellitus. Lancet 1982; 1: 1430–1432.

    Article  PubMed  CAS  Google Scholar 

  9. Mogensen CE, Christensen CK: Predicting diabetic nephropathy in insulin-dependent patients. N Engl J Med 1984; 311: 89–93.

    Article  PubMed  CAS  Google Scholar 

  10. Mathiesen ER, Oxenb0Ü B, Johansen K, Svendsen PAa, Deckert T: Incipient nephropathy in Type 1 (insulin-dependent) diabetes. Diabetologia 1984; 26: 406–410.

    Article  PubMed  CAS  Google Scholar 

  11. Jensen T: Albuminuria — a marker of renal and generalized vascular disease in insulin-dependent diabetes mellitus. Dan Med Bull 1991; 38: 134–144.

    PubMed  CAS  Google Scholar 

  12. Feldt-Rasmussen B: Microalbuminuria and clinical nephropathy in Type 1 (insulin-dependent) diabetes mellitus: pathophysiological mechanisms and intervention studies. Dan Med Bull 1989; 36: 405–415.

    PubMed  CAS  Google Scholar 

  13. Deckert T, Feldt-Rasmussen B, Borch-Johnsen K, Jensen T, Kofoed-Enevoldsen A: Albuminuria reflects widespread vascular damage. The Steno hypothesis. Diabetologia 1989; 32: 216–226.

    Google Scholar 

  14. Mogensen CE: Microalbuminuria predicts clinical proteinuria and early mortality in maturity onset diabetes N Engl J Med 1984; 310: 356–336.

    CAS  Google Scholar 

  15. Jarrett RJ, Viberti GC, Argyropoulos A, Hill RD, Mahmud U, Murrells TJ: Microalbuminuria predicts mortality in non-insulin-dependent diabetes. Diabetic Med 1984; 1: 17–19.

    Article  PubMed  CAS  Google Scholar 

  16. Yudkin JS, Forrest RD, Jackson CA: Microalbuminuria as predictor of vascular disease in non-diabetic subjects. Lancet 1988; 2: 530–533.

    Article  PubMed  CAS  Google Scholar 

  17. Damsgaard EM, Freland A, J0rgensen OD, Mogensen CE: Micro-albuminuria as predictor of increased mortality in elderly people. BMJ 1990; 300: 297–300.

    Article  PubMed  CAS  Google Scholar 

  18. Messent JWC, Elliott TG, Hill RD, Jarrett RJ, Keen H, Viberti GC: Prognostic significance of microalbuminuria in insulin-dependent diabetes mellitus: a twenty year follow-up study. Kidney Int 1992; 41: 836–839.

    Article  PubMed  CAS  Google Scholar 

  19. Marre M, Chatellier G, Leblanc H, Guyene TT, Menard J, Passa P: Prevention of diabetic nephropathy with enalapril in normotensive diabetics with microalbuminuria. BMJ 1988; 297: 1092–1095.

    Article  PubMed  CAS  Google Scholar 

  20. Mathiesen ER, Hommel E, Giese J, Parving H-H: Efficacy of Captopril in postponing nephropathy in normotensive insulin-dependent diabetic patients with microalbuminuria. BMJ 1991; 303: 81–87.

    Article  PubMed  CAS  Google Scholar 

  21. Melbourne Diabetic nephropathy study group: Comparison between Perindopril and nifedipine in hypertensive and normotensive diabetic patients with microalbuminuria. BMJ 1991; 302: 210–216.

    Article  Google Scholar 

  22. Feldt-Rasmussen B, Mathiesen ER, Jensen T, Lauritzen T, Deckert T: Effect of improved metabolic control on loss of kidney function in Type 1 (insulin-dependent) diabetic patients: an update of the Steno studies. Diabetologia 1991; 34: 164–170.

    Article  PubMed  CAS  Google Scholar 

  23. Marshall SM, Albert KGMM: Comparison of the prevalence and associated features of abnormal albumin excretion in insulin-dependent and non-insulin dependent diabetes. Q J Med 1989; 70: 61–71.

    PubMed  CAS  Google Scholar 

  24. Borch-Johnsen K: Predictive value of microalbuminuria in long standing insulin dependent diabetes, (letter) BMJ 1993; 306: 271–272.

    CAS  Google Scholar 

  25. Mogensen CE: Long-term antihypertensive treatment inhibiting progression of diabetic nephropathy. BMJ 1982; 285: 685–688.

    Article  PubMed  CAS  Google Scholar 

  26. Parving H-H, Andersen ARE, Smidt UM, Svendsen PAa: Early aggressive antihypertensive treatment reduces the rate of decline in kidney function in diabetic nephropathy. Lancet 1983; 1: 1175–1179.

    Article  PubMed  CAS  Google Scholar 

  27. Mathiesen ER, Borch-Johnsen K, Jensen DV, Deckert T: Improved survival in patients with diabetic nephropathy. Diabetologia 1989; 32: 884–886.

    Article  PubMed  CAS  Google Scholar 

  28. Eggers PW: Health Care Policies/economics of the geriatric renal population. Am J Kidney Dis 1990; 16: 384–391.

    PubMed  CAS  Google Scholar 

  29. Siegel JE, Krolewski AS, Warram JH, Weinstein MC: Cost-effectiveness of screening and early treatment of nephropathy in patients with insulin-dependent diabetes mellitus. J Am Soc Nephrol 1992; 3: 3111–3119.

    Google Scholar 

  30. Borch-Johnsen K, Wenzel H, Viberti GC, Mogensen CE: Is screening and intervention for Microalbuminuria worthwhile in patients with insulin dependent diabetes? BMJ 1993; 306: 1722–1725.

    Article  PubMed  CAS  Google Scholar 

  31. Ramlau-Hansen H, Bang Jespersen NC, Andersen PK, Borch-Johnsen K, Deckert T: Life insurance for insulin-dependent diabetics. Scandinavian Actuarial Journal 1987; pp 19–36.

    Google Scholar 

Download references

Authors
  1. Knut Borch-Johnsen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medical Department M (Diabetes & Endocrinology) Aarhus Kommunehospital, University Hospitals in Aarhus, Aarhus C, Denmark

    Carl Erik Mogensen

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Borch-Johnsen, K. (1994). Incidence of Nephropathy in Insulin-Dependent Diabetes Mellitus as Related to Mortality and Cost-Benefit of Early Intervention. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6746-9_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6746-9_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6748-3

  • Online ISBN: 978-1-4757-6746-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation