Skip to main content
SpringerLink
Log in
Book cover

The Kidney and Hypertension in Diabetes Mellitus pp 27–35Cite as

Familial Factors in Diabetic Nephropathy

  • Chapter

Abstract

Reports of nephropathy developing in some patients with apparently well controlled diabetes and not developing in some patients even after years of severe hyperglycemia lead to the conclusion, expressed by several researchers [1–5], that some individuals are and others are not predisposed to the development of diabetic renal disease. If this predisposition is genetic, there must be an interaction between the genes and the environment, and it is often impossible to differentiate between genetic inheritance and the effect of a common environment shared by family members. This chapter reviews some of the data which indicate that there are familial differences in the predisposition to the development of diabetic renal disease.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Deckert T, Poulsen JE. Diabetic nephropathy: fault or destiny? Diabetologia 1981; 21: 178–183.

    PubMed  CAS  Google Scholar 

  2. Moloney A, Tunbridge WMG, Ireland JT, Watkins PJ . Mortality from diabetic nephropathy in the United Kingdom. Diabetologia 1983; 25: 26–30.

    Article  PubMed  CAS  Google Scholar 

  3. Krolewski AS, Warram JH, Christlieb AR, Busick EJ, Kahn CR. The changing natural history of nephropathy in type I diabetes. Am J Med 1985; 78: 785–794.

    Article  PubMed  CAS  Google Scholar 

  4. Seaquist ER, Goetz FC, Povey S. Diabetic nephropathy: an hypothesis regarding genetic susceptibility for the disorder. Minn Med 1986; 69: 457–459.

    PubMed  CAS  Google Scholar 

  5. What causes diabetic renal failure? [Editorial] Lancet 1988; i: 1433–1434.

    Google Scholar 

  6. Rostand SG, Kirk KA, Rutsky EA, Pate BA. Racial differences in the incidence of treatment for end-stage renal disease. N Engl J Med 1982; 306: 1276–1279.

    Article  PubMed  CAS  Google Scholar 

  7. Pugh JA, Stern MP, Haffner SM, Eifler CW, Zapata M. Excess incidence of treatment of end-stage renal disease in Mexican Americans. Am J Epidemiol 1988; 127: 135–144.

    PubMed  CAS  Google Scholar 

  8. Haffner SM, Mitchell BD, Pugh JA, Stern MP, Kozlowski MK, Hazuda HP, Patterson JK, Klein R. Proteinuria in Mexican Americans and non-Hispanic Whites with NIDDM. Diabetes Care 1989; 12: 530–536.

    Article  PubMed  CAS  Google Scholar 

  9. Cowie CC, Port FK, Wolfe RA, Savage PJ, Moll PP, Hawthorne VM. Disparities in incidence of diabetic end-stage renal disease according to race and type of diabetes. N Engl J Med 1989; 321: 1074–1079.

    Article  PubMed  CAS  Google Scholar 

  10. Rostand SG. Diabetic renal disease in blacks — inevitable or preventable? [Editorial]. N Engl J Med 1989; 321: 1121–1122.

    Article  PubMed  CAS  Google Scholar 

  11. Nelson RG, Newman JM, Knowler WC, Sievers ML, Kunzelman CL, Pettitt DJ, Moffett CD, Teutch SM, Bennett PH. Incidence of end-stage renal disease in type 2 (non-insulin-dependent) diabetes mellitus in Pima Indians. Diabetologia 1988; 31: 730–736.

    Article  PubMed  CAS  Google Scholar 

  12. Kunzelman CL, Knowler WC, Pettitt DJ, Bennett PH. Incidence of proteinuria in type 2 diabetes mellitus in the Pima Indians. Kidney Int 1989; 35: 681–687.

    Article  PubMed  CAS  Google Scholar 

  13. Nelson RG, Knowler WC, Pettitt DJ, Saad MF, Bennett PH. Diabetic kidney disease in Pima Indians. Diabetes Care 1993; 16: suppl. 1: 335–341.

    Article  PubMed  CAS  Google Scholar 

  14. Nelson RG, Knowler WC, McCance DR, Sievers ML, Pettitt DJ, Charles MA, Hanson RL, Liu QZ, Bennett PH. Determinants of end-stage renal disease in Pima Indians with Type 2 (non-insulin-dependent) diabetes mellitus and proteinuria. Diabetologia 1993; 36: 1087–1093.

    Article  PubMed  CAS  Google Scholar 

  15. Bennett PH, Burch TA, Miller M. Diabetes mellitus in American (Pima) Indians. Lancet 1971; ii: 125–128.

    Article  Google Scholar 

  16. Knowler WC, Pettitt DJ, Saad MF, Bennett PH. Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis. Diabetes Metab Rev 1990; 6: 1–27.

    Article  PubMed  CAS  Google Scholar 

  17. Seaquist ER, Goetz FC, Rich S, Barbosa J. Familial clustering of diabetic kidney disease: evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med 1989; 320: 1161–1165.

    Article  PubMed  CAS  Google Scholar 

  18. Borch-Johnsen K, Nørgaard, Hommel E, Mathiesen ER, Jensen JS, Deckert T, Parving H-H. Is diabetic nephropathy an inherited complication? Kidney Int 1992; 41: 719–722.

    Article  PubMed  CAS  Google Scholar 

  19. Pettitt DJ, Saad MF, Bennett PH, Nelson RG, Knowler WC. Familial predisposition to renal disease in two generations of Pima Indians with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1990; 33: 438–443.

    Article  PubMed  CAS  Google Scholar 

  20. McCance DR, Nelson RG, Jacobbson L, Bishop DT, Knowler WC. Nephropathy in diabetic parents: a risk factor for diabetes in offspring [abstr]. Diabetes 1993; 42: suppl. 1: 135A.

    Google Scholar 

  21. Viberti GC, Keen H, Wiseman MI. Raised arterial pressure in parents of proteinuric insulin dependent diabetics. BMJ 1987; 295: 515–517.

    Article  PubMed  CAS  Google Scholar 

  22. Krolewski AS, Canessa M, Warram JH, Laffel LMB, Christlieb AR, Knowler WC, Rand LI. Predisposition to hypertension and susceptibility to renal disease in insulindependent diabetes mellitus. N Engl J Med 1988; 318: 140–145.

    Article  PubMed  CAS  Google Scholar 

  23. Beatty OL, Harper R, Sheridan B, Atkinson AB, Bell PM. Insulin resistance in offspring of hypertensive parents. BMJ 1993; 307: 92–96.

    Article  PubMed  CAS  Google Scholar 

  24. Canessa M, Adragna N, Solomon HS, Connolly TM, Tosteson DC. Increased sodiumlithium countertransport in red cells of patients with essential hypertension. N Engl J Med 1980; 302: 772–776.

    Article  PubMed  CAS  Google Scholar 

  25. Woods JW, Falk RJ, Pittman AW, Klemmer PJ, Watson BS, Namboodiri K. Increased red-cell sodium-lithium countertransport in normotensive sons of hypertensive parents. N Engl J Med 1982; 306: 593–595.

    Article  PubMed  CAS  Google Scholar 

  26. Clegg G, Morgan DB, Davidson C. The heterogeneity of essential hypertension: relation between lithium efflux and sodium content of erythrocytes and a family history of hypertension. Lancet 1982; ii: 891–894.

    Article  Google Scholar 

  27. Cooper R, LeGrady D, Nanas S, Trevisan M, Mansour M, Histand P, Ostrow D, Stamler J. Increased sodium-lithium countertransport in college students with elevated blood pressure. JAMA 1983; 249: 1030–1034.

    Article  PubMed  CAS  Google Scholar 

  28. Mangili R, Bending JJ, Scott G, Li LK, Gupta A, Viberti GC. Increased sodium-lithium countertransport activity in red cells of patients with insulin-dependent diabetes and nephropathy. N Engl J Med 1988; 318: 146–150.

    Article  PubMed  CAS  Google Scholar 

  29. Kelleher C, Kingston SM, Barry DG, Cole MM, Ferriss JB, Grealy G, Joyce C, O’Sullivan DJ. Hypertension in diabetic clinic patients and their siblings. Diabetologia 1988; 31: 76–81.

    Article  PubMed  CAS  Google Scholar 

  30. Nelson RG, Pettitt DJ, Baird HR, Charles MA, Liu QZ, Bennett PH, Knowler WC. Prediabetic blood pressure predicts urinary albumin excretion after the onset of Type 2 (noninsulin-dependent) diabetes mellitus in Pima Indians. Diabetologia 1993; 36: 998–1001

    Article  PubMed  CAS  Google Scholar 

  31. Barbosa J. Is diabetic microangiopathy genetically heterogeneous? HLA and diabetic nephropathy. Horm Metab Res 1981; 11: suppl.: 77–80.

    CAS  Google Scholar 

  32. Scaldaferri E, Devidè A. Microangiopatia diabetica: esiste una suscettibilità genetica HLA-correlata? Minerva Endocrinol 1985; 10: 115–124.

    PubMed  CAS  Google Scholar 

  33. Christy M, Anderson AR, Nerup J, Platz P, Ryder L, Thomsen M, Morling M, Svejgaard A. HLA/DR in longstanding IDDM with and without nephropathy — evidence for heterogeneity? [abstr]. Diabetologia 1981; 21: 259.

    Google Scholar 

  34. Walton C, Dyer PA, Davidson JA, Harris R, Mallick NP, Oleesky S. HLA antigens and risk factors for nephropathy in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1984; 27: 3–7.

    Article  PubMed  CAS  Google Scholar 

  35. Mijovic C, Fletcher JA, Bradwell AR, Barnett AH. Phenotypes of the heavy chains of immunoglobulins in patients with diabetic microangiopathy: evidence for an immunogenetic predisposition. BMJ 1986; 292: 433–435.

    Article  PubMed  CAS  Google Scholar 

  36. Barbosa J, Saner B. Do genetic factors play a role in the pathogenesis of diabetic microangiopathy? Diabetologia 1984; 27: 487–492.

    Article  PubMed  CAS  Google Scholar 

  37. Barnett AH, Pyke DA. The genetics of diabetic complications. Baillieres Clin Endocrinol Metab 1986; 15: 715–726.

    Article  CAS  Google Scholar 

  38. Reichard P, Nilsson B-Y, Rosenqvist U. The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. N Engl J Med 1993; 329: 304–309.

    Article  PubMed  CAS  Google Scholar 

  39. DCCT update. Presented at the scientific sessions of the 53rd annual meeting of the American Diabetes Association, Las Vegas, June 1993.

    Google Scholar 

  40. Krishna GP, Newell G, Miller E, Heeger P, Smith R, Polansky M, Kapoor S, Hoeldtke R. Protein-induced glomerular hyperfiltration: role of hormonal factors. Kidney Int 1988; 33: 578–583.

    Article  PubMed  CAS  Google Scholar 

  41. Wiseman MJ, Dodds R, Bending JJ, Viberti GC. Dietary protein and the diabetic kidney. Diabetic Med 1987; 4: 144–146.

    Article  PubMed  CAS  Google Scholar 

  42. Walker JD, Dodds RA, Murrells TJ, Bending JJ, Mattock MB, Keen H, Viberti GC. Restriction of dietary protein and progression of renal failure in diabetic nephropathy. Lancet 1989; ii: 1411–1415.

    Article  Google Scholar 

  43. Mitch WE. Dietary protein restriction in chronic renal failure: nutritional efficacy, compliance, and progression of renal insufficiency. J Am Soc Nephrol 1991; 2: 823–831.

    PubMed  CAS  Google Scholar 

  44. Zeller K, Whittaker E, Sullivan L, Raskin P, Jacobson HR. Effect of restricting dietary protein on the progression of renal failure in patients with insulin-dependent diabetes mellitus. N Engl J Med 1991; 324: 78–84.

    Article  PubMed  CAS  Google Scholar 

  45. Nakamura H, Ito S, Ebe N, Shibata A. Renal effects of different types of protein in healthy volunteer subjects and diabetic patients. Diabetes Care 1993; 16: 1071–1075.

    Article  PubMed  CAS  Google Scholar 

  46. Mogensen CE. Long-term antihypertensive treatment inhibiting progression of diabetic nephropathy. BMJ 1982; 285: 685–688.

    Article  PubMed  CAS  Google Scholar 

  47. Parving H-H, Hommel E, Smidt UM. Protection of kidney function and decrease in albuminuria by captopril in insulin dependent diabetics with nephropathy. BMJ 1988; 297: 1086–1091.

    Article  PubMed  CAS  Google Scholar 

  48. Mathiesen ER, Hommel E, Giese J, Parving H-H. Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. BMJ 1991; 303: 81–87.

    Article  PubMed  CAS  Google Scholar 

  49. Ravid M, Savin H, Jutrin I, Bental T, Katz B, Lishner M. Long-term stabilizing effect of angiotensin-converting enzyme inhibition on plasma creatinine and on proteinuria in normotensive type II diabetic patients. Ann Intern Med 1993; 118: 577–581.

    Article  PubMed  CAS  Google Scholar 

  50. Lewis EJ, Hunsicker LG, Bain RP, Rhode RD. The effect of angiotensin-convertingenzyme inhibition on nephropathy. N Engl J Med 1993; 329: 1456–1462.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. David J. Pettitt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. William C. Knowler
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medical Department M (Diabetes & Endocrinology) Aarhus Kommunehospital, University Hospitals in Aarhus, Aarhus C, Denmark

    Carl Erik Mogensen

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Pettitt, D.J., Knowler, W.C. (1994). Familial Factors in Diabetic Nephropathy. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6746-9_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6746-9_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6748-3

  • Online ISBN: 978-1-4757-6746-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation