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Purification and Properties of Two Sphingolipid Hydrolases

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Sphingolipids, Sphingolipidoses and Allied Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 19))

Abstract

Our understanding of the lipid storage disorders has progressed dramatically since 1881 when Warren Tay, a British opthalmologist, described a cherry-red macular degeneration in the fundus of an infant with marked weakness of the trunk and limbs (1). This patient was the first reported case of Tay-Sachs disease. In the 90 years that have followed, there has been a delineation of a large number of inherited met abolic disorders characterized by the accumulation within tissues of large amounts of lipids.

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References

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Author information

Authors and Affiliations

  1. Molecular Disease Branch, National Heart and Lung Institute, USA

    Howard R. Sloan, Jan L. Breslow & Donald S. Fredrickson

Authors
  1. Howard R. Sloan
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  2. Jan L. Breslow
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  3. Donald S. Fredrickson
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Editor information

Editors and Affiliations

  1. Isaac Albert Research Institute of the Kingsbrook Jewish Medical Center and Department of Pathology, Downstate Medical Center, State University of New York, Brooklyn, New York, USA

    Bruno W. Volk

  2. Department of Pathology, Miriam Hospital and Brown University, Providence, Rhode Island, USA

    Stanley M. Aronson

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© 1972 Springer Science+Business Media New York

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Sloan, H.R., Breslow, J.L., Fredrickson, D.S. (1972). Purification and Properties of Two Sphingolipid Hydrolases. In: Volk, B.W., Aronson, S.M. (eds) Sphingolipids, Sphingolipidoses and Allied Disorders. Advances in Experimental Medicine and Biology, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6570-0_12

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  • DOI: https://doi.org/10.1007/978-1-4757-6570-0_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6572-4

  • Online ISBN: 978-1-4757-6570-0

  • eBook Packages: Springer Book Archive

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