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Fine Structure of Early Tay-Sachs Disease

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Book cover Sphingolipids, Sphingolipidoses and Allied Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 19))

Abstract

Tay-Sachs disease is an inborn error of glycolipid. It is characterized by massive accumulation of GM2-ganglioside (4), mainly in the brain and by the absence of the enzyme hexosaminidase A (5). Despite the significant increase of our knowledge of the biochemical aspects of this disorder during the past few years, the ultrastructural alterations of the neuronal organelles related to the accumulation and the evolution of the intracytoplasmic deposited lipid material at the early stage of Tay-Sachs disease are unknown.

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References

  1. Adachi, M., Torii, J., Karvounis, P.C., and Volk, B.W.: Alterations of Astrocytic Organelles in Various Lipidoses and Allied Diseases. Acta Neuropath., 18, 74, 1971.

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Author information

Authors and Affiliations

  1. Isaac Albert Research Institute of the Kingsbrook Jewish Medical Center, Brooklyn, New York, USA

    M. Adachi, J. Torii, L. Schneck & B. W. Volk

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  1. M. Adachi
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  2. J. Torii
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  3. L. Schneck
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  4. B. W. Volk
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Editor information

Editors and Affiliations

  1. Isaac Albert Research Institute of the Kingsbrook Jewish Medical Center and Department of Pathology, Downstate Medical Center, State University of New York, Brooklyn, New York, USA

    Bruno W. Volk

  2. Department of Pathology, Miriam Hospital and Brown University, Providence, Rhode Island, USA

    Stanley M. Aronson

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© 1972 Springer Science+Business Media New York

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Adachi, M., Torii, J., Schneck, L., Volk, B.W. (1972). Fine Structure of Early Tay-Sachs Disease. In: Volk, B.W., Aronson, S.M. (eds) Sphingolipids, Sphingolipidoses and Allied Disorders. Advances in Experimental Medicine and Biology, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6570-0_1

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  • DOI: https://doi.org/10.1007/978-1-4757-6570-0_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6572-4

  • Online ISBN: 978-1-4757-6570-0

  • eBook Packages: Springer Book Archive

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