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Sex Hormone Replacement Therapy pp 31–42Cite as

Sex Hormone Therapy for Dementia

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Part of the book series: Endocrine Updates ((ENDO,volume 8))

Abstract

The brain has receptors for steroid hormones, including estrogens, androgens, and progestogens. Many effects of sex hormones within the central nervous system are dependent on interactions with specific intracellular receptors. Pairs of hormone-receptor complexes, together with associated regulatory proteins, bind to portions of the genome known as hormone response elements in the promoter region of specific genes. Binding serves to enhance or inhibit downstream gene transcription and ultimately the synthesis of specific protein products within these target neurons (1).

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Authors and Affiliations

  1. University of Southern California, Los Angeles, California, 90089, USA

    Victor W. Henderson M.D., M.S.

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  1. Victor W. Henderson M.D., M.S.
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Editors and Affiliations

  1. Monash Medical Centre, Prince Henry’s Institute of Medical Research, Melbourne, Victoria, Australia

    Henry G. Burger

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Henderson, V.W. (2000). Sex Hormone Therapy for Dementia. In: Burger, H.G. (eds) Sex Hormone Replacement Therapy. Endocrine Updates, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6507-6_3

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  • DOI: https://doi.org/10.1007/978-1-4757-6507-6_3

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