Abstract
Protein C (PC) is a glycoprotein that plays a pivotal role as an anticoagulant, antithromobotic, and thrombolytic therapeutic in the blood coagulation cascade (Esmon, 1989). It is a member of the vitamin K-dependent (VKD) family also consisting of coagulation protein factors VII, IX, X, proteins S, Z and prothrombin. Human PC is synthesized in the liver as a single chain precursor and circulates in the blood primarily as a two chain zymogen that is activated by proteolytic clevage. Activated PC is a potent serine protease that regulates blood coagulation by deactivating factors Va and VIIIa (a: activated form), thus preventing generation of the enzyme factors Xa and thrombin (Wu and Bruley, 1999).
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Nandakumar, R., Afshari, H., Bruley, D.F. (2003). Analysis of Equilibrium Adsorption Isotherms for Human Protein C Purification by Immobilized Metal Affinity Chromatography. In: Thorniley, M., Harrison, D.K., James, P.E. (eds) Oxygen Transport to Tissue XXV. Advances in Experimental Medicine and Biology, vol 540. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6125-2_27
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DOI: https://doi.org/10.1007/978-1-4757-6125-2_27
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