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Warfarin and Bone: Implications for Rational Strategies to Selectively Antagonize the Action of Vitamin K in Target Tissues

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Abstract

We have recently reported that vitamin K counteracts the action of Warfarin on blood coagulation but not on the synthesis of bone Gla protein (BGP; osteocalcin) (1). The purpose of this paper is to describe the observations which led to this discovery and the implications of this discovery for Warfarin prophylaxis.

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© 1987 Springer Science+Business Media New York

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Price, P.A. (1987). Warfarin and Bone: Implications for Rational Strategies to Selectively Antagonize the Action of Vitamin K in Target Tissues. In: Wessler, S., Becker, C.G., Nemerson, Y. (eds) The New Dimensions of Warfarin Prophylaxis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5985-3_5

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  • DOI: https://doi.org/10.1007/978-1-4757-5985-3_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5987-7

  • Online ISBN: 978-1-4757-5985-3

  • eBook Packages: Springer Book Archive

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