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Biosynthesis of Glycosaminoglycans and Proteoglycans

  • Chapter
Neurobiology of Glycoconjugates

Abstract

The class of polysaccharides known as glycosaminoglycans consists of repeated disaccharides, usually containing a sulfated hexosamine and uronic acid. As abundant constituents of extracellular matrices, most work on glycosaminoglycans has focused on their roles in cartilage, bone, and synovial fluid, where they are thought to be important for tissue turgor and hydration, ion binding and buffering, and tensile strength and resiliency. Early interest in the biosynthesis of glycosaminoglycans was generated by the discovery of lysosomal storage diseases and disorders of connective tissue metabolism such as arthritis.

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Authors and Affiliations

  1. Departments of Pediatrics and Biochemistry and Molecular Biology, and the Kennedy Mental Retardation Research Center, University of Chicago, Chicago, Illinois, 60637, USA

    Nancy B. Schwartz

  2. Department of Pediatrics and the Kennedy Mental Retardation Research Center, University of Chicago, Chicago, Illinois, 60637, USA

    Neil R. Smalheiser

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  1. Department of Pharmacology, New York University Medical Center, 10016, New York, New York, USA

    Richard U. Margolis

  2. Department of Pharmacology, State University of New York, Health Science Center at Brooklyn, 11203, Brooklyn, New York, USA

    Renée K. Margolis

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Schwartz, N.B., Smalheiser, N.R. (1989). Biosynthesis of Glycosaminoglycans and Proteoglycans. In: Margolis, R.U., Margolis, R.K. (eds) Neurobiology of Glycoconjugates. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5955-6_5

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