Abstract
Infection of humans with Mycobacterium tuberculosis provides an attractive model for investigating regulation of the immune response for several reasons. First, the causative agent is cultivable on synthetic medium and a cDNA genomic expression library has been prepared. Therefore, purified native and recombinant mycobacterial antigens can be tested directly for immunoregulatory activity. Second, the immune response in healthy subjects with delayed-type hypersensitivity (DTH) to mycobacteria can be contrasted to patients with tuberculosis to elucidate patterns of immunoregulation which are characteristic of disease. Third, although infection with M. tuberculosis or attenuated mycobacteria is an excellent model for DTH in experimental systems, the paradoxic occurrence of anergy in some patients can be explored in the laboratory.
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References
Rooney, J.J. Jr., J.A. Crocco, S. Kramer, and H.A. Lyons. 1976. Further observations on tuberculin reactions in tuberculosis. Am. J. Med. 60: 517.
Kleinhenz, M.E., J.J. Ellner, P.J. Spagnuolo, and T.M. Daniel. 1981. Suppression of lymphocyte responses by tuberculous plasma and mycobacterial arabinogalactan: monocyte-dependence and indomethacin reversibility. J. Clin. Invest. 68: 153.
Ellner, J.J. Suppressor adherent cells in human tuberculosis. 1978. J. Immunol. 121: 2573.
Kleinhenz, M.E., and J.J. Ellner. 1985. Immunoregulatory adherent cells in human tuberculosis: radiation-sensitive antigen-specific suppression by monocytes. J. Infect. Dis. 152: 171.
Tweardy, D.J., B.Z. Schacter, and J.J. Ellner. 1984. Association of altered dynamics of monocyte surface expression of human leukocyte antigen DR with immunosuppression in tuberculosis. J. Infect. Dis. 149: 31.
Wallis, R.S., H. Fujiwara, and J.J. Ellner. 1986. Direct stimulation of monocyte release of interleukin-1 by mycobacterial protein antigens. J. Immunol. 136: 193.
Fujiwara, H., M.E. Kleinhenz, R.S. Wallis, and J.J. Ellner. 1986. Increased interleukin-1 production and monocyte suppressor cell activity associated with human tuberculosis. Am. Rev. Respir. Dis. 133: 73.
Toossi, Z., M.E. Kleinhenz, and J.J. Ellner. 1986. Defective interleukin-2 production and responsiveness in human pulmonary tuberculosis. J. Exp. Med. 163: 1162.
Fujiwara, H., and J.J. Ellner. 1986. Spontaneous production of a suppressor factor by the human macrophage-like cell line U937. I. Suppression of interleukin-1, interleukin-2 and mitogen-induced blastogenesis in mouse thymocytes. J. Immunol. 136: 181.
Bloom, B.R., and V. Mehra. 1984. Immunological unresponsiveness in leprosy. Immunol. Rev. 80: 5.
Piessens, W.F., F. Partono, S.L. Hoffman, S. Ratiwayanto, P.W. Piessens, J.R. Palmieri, I. Koiman, D.T. Dennis, and W.P. Carney. 1982. Antigen-specific suppressor T-lymphocytes in human lymphatic filariasis. N. Engl. J. Med. 307: 144.
Olds, G.R., A. El Kholy, and J.J. Ellner. 1983. Two distinctive patterns of monocyte immunoregulatory and effector functions in heavy human infections with Schistosoma mansoni. J. Immunol. 131: 954.
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© 1988 Springer Science+Business Media New York
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Ellner, J.J. (1988). Immunoregulation in Human Tuberculosis. In: Eisenstein, T.K., Bullock, W.E., Hanna, N. (eds) Host Defenses and Immunomodulation to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 239. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5421-6_29
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DOI: https://doi.org/10.1007/978-1-4757-5421-6_29
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