Abstract
Trypanosome musculi, a natural parasite of mice, produces a self-limiting infection which lasts for approximately 3 weeks and comprises an early growth phase, a plateau phase and an elimination phase (1). The mechanism of protection which controls the early growth of the parasite, leading to the plateau phase, is not well understood but is known to be highly sensitive to ionizing radiation. Macrophages of the reticuloendothelial system also become activated at this time (2). We have shown recently that elimination of parasitaemia and termination of the infection depends on an effector mechanism involving a thermolabile, anti-trypanosomal IgG2a antibody, complement component C3 and an effector cell, possibly a macrophage (3,4).
Chapter PDF
References
Viens, P., Targett, G.A.T., Leuchars, and Davies, A.J., 1974. The immunological response of CBA mice to Trypanosoma musculi. I. Initial control of the infection and the effect of T-cell deprivation. Clin. Exp. Immunol., 16: 279.
Rapattoni, W., Ghadirian, E., and Kongshavn, P.A.L., 1984. Importance of cellular mechanisms in controlling murine trypanosomiasis. Abst. #7, 21st National RES Meeting.
Wechsler, D.S., and Kongshavn, P.A.L., 1985. Characterization of antibodies mediating protection and cure of Trypanosoma musculi infection in mice. Infect. Immun., 48 (3): 787.
Wechsler, D.S., and Kongshavn, P.A.L., 1986. Heat-labile IgG2a antibodies effect cure of Trypanosoma musculi infection in C57BL/6 mice. J. Immunol. 137: 2968–2972.
Carswell, E.A., Old, L.J., Kassel, R.L., Green, S., Fiore, N., and Williamson, B., 1975. An endotoxin-induced serum factor that causes necrosis of tumors. Proc. Natl. Acad. Sci. USA, 72: 3666.
Beutler, B., Greenwald, D., Hulmes, J.D., Chang, M., Pan, Y.-C.E., Mathison, J., Ulevitch, R., and Cerami, A., 1985. Identity of tumor necrosis factor and the macrophage-secreted factor cachectin. Nature, 316: 552.
Taverne, J., Dockrell, H.M., and Playfair, J.H.L., 1981. Endotoxin-induced serum factor kills malarial parasites in vitro. Infect. Immun., 33: 83.
De Titto, E.H., Catterall, J.R., and Remington, J.S., 1986. Activity of recombinant tumor necrosis factor on Toxoplasma Gondii and Trypanosoma cruzi. J. Immunol., 137: 1342.
Beutler, B., and Cerami, A., 1987. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature, 320: 588.
Wechsler, D.S., and Kongshavn, P.A.L., 1984. Cure of Trypanosoma musculi infection by heat-labile activity in immune plasma. Infect. Immun. 44 (3): 756.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer Science+Business Media New York
About this chapter
Cite this chapter
Kongshavn, P.A.L., Ghadirian, E. (1988). Effect of Tumor Necrosis Factor on Growth of Trypanosoma Musculi in Vivo and in Vitro. In: Eisenstein, T.K., Bullock, W.E., Hanna, N. (eds) Host Defenses and Immunomodulation to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 239. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5421-6_26
Download citation
DOI: https://doi.org/10.1007/978-1-4757-5421-6_26
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-5423-0
Online ISBN: 978-1-4757-5421-6
eBook Packages: Springer Book Archive