Abstract
There is an ever growing interest in the study of the polyphenols. Their importance in the prevention of chronic disease is gradually being unfolded. Examples range from those such as the flavonoid quercitin and the stilbene resveratrol in red wine (Das et al., 1999) to the isoflavonoids daidzein, genistein and glycitein in soy (Barnes, 1998).
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Barnes, K. A., Smith, R.A., Williams, K., Damant. A.P., and Shepherd, M. J., 1998a, A microhore high performance liquid chromatography/electrospray ionization mass spectrometry method for the determination of the phytoestrogens genistein and daidzein in comminuted baby foods and soya flour, Rapid Commun. Mass Spectrom,12:130–138.
Barnes, N. C., 1993, The American groundnut, Apios americana, contains a glycoside of the antitumor agent genistein, North Central Alabama High School Science Fair, 1993.
Barnes, S., 1998, Evolution of the history of soy and genistein. Proc. Soc. Exp. Bio!. Med. 217: 386–392.
Barnes, S., Coward, L., and Kirk, M., 1998b, HPLC-mass spectrometry analysis of isoflavones, Proc. Soc. Exp. Biol. Med. 217: 254–262.
Barnes, S., Kirk, M., and Coward, L. J., 1994, Isoflavones and their conjugates in soy foods: extraction conditions and analysis by HPLC-mass spectrometry, Agric. Food Chem. 42: 2466–2474.
Barnes, S., Wang, C-C., Smith-Johnson, M., and Kirk, M., 1999, Liquid chromatography-mass spectrometry of isoflavones, J. Med. Food 2: 111–117.
Boersma, B. J., Patel, R. P., Kirk, M., Darley-Usmar, V. M., and Barnes, S., 1999, Chlorination and nitration of soy isoflavones, Arch. Biochem. Biophys. 368: 265–275.
Boersma, B. J., Patel, R. P., Kirk, M., Muccio, D. D., Darley-Usmar, V. M., and Barnes, S., 2001, Bromination, chlorination and nitration of isoflavonoids, In: Free Radicals in Foods: Chemistry, Nutrition and Health,Morello, M.., ed., ACS Press, in press.
Cimino, C. O., Shelnutt, S. R., Ronis, M. J. J.. and Badger, T. M., 1999, An LC-MS method to determine concentrations of isoflavones and their sulfate and glucuronide conjugates in urine, Clin. Chim. Acta 287: 69–82.
Coldham, N. G., Howells, L. C., Santi, A., Montesissa, C., Langlais, C., King, L. J., Macpherson, D. D., and Sauer, M. J., 1999, Biotransformation of genistein in the rat: elucidation of metabolite structure by product ion mass fragmentology, J. Ster. Biochem. Mol. Bio!. 70: 169–184.
Coward, L., Barnes, N. C., Setchell, K. D. R., and Barnes, S., 1993, The antitumor isoflavones, genistein and daidzein, in soybean foods of American and Asian diets, J. Agric. Food Chem. 41: 1961–1967.
Coward, L., Kirk. M., Albin, N., and Barnes, S., 1996, Analysis of plasma isoflavones by reversed-phase HPLCmultiple reaction monitoring-mass spectrometry, Clin. Chini. Acta, 247: 121–142.
Coward, L., Smith, M„ Kirk, M, and Barnes, S., 1998, Chemical modification of isoflavones in soy foods during cooking and processing, Am. J. Clin. Nutr. 68: 1486S–1491S.
Das, D. K., Sato, M., Ray, P. S., Maulik, G., Engelman, R. M., Bertelli, A. A., and Bertelli, A., 1999, Cardioprotection of red wine: role of polyphenolic antioxidants, Drugs Exp. Clin. Res. 25: 115–120.
Doerge, D. R., Chang, H. C., Churchwell, M. I., and Holder, C. L., 2000. Analysis of soy isoflavone conjugation in vitro and in human blood using liquid chromatography-mass spectrometry, Drug Moab. Disp. 28: 298–307.
Geromanos, S., Freckleton, G., and Tempst. P., 2000, Tuning of an electrospray ionization source for maximum peptide-ion transmission into a mass-spectrometer, Anal. Chem. 72: 777–790.
Holder, C. L., Churchwell, M. l., and Doerge, D. R., 1999, Quantification of soy isoflavones, genistein and daidzein, and conjugates in rat blood using LC/ES-MS, J Agric. Food Chem. 47: 3764–3770.
Merken, H. M., and Beecher, G. R., 2000, Measurement of food flavonoids by high-performance liquid chromatography: A review, J. Agric. Food Chem. 48: 577–599.
Morton, M., Arisaka, O., and Miyake A., 1999, Analysis of phyto-oestrogens by gas chromatography-mass spectrometry, Environ. Toxicol. Phar. 7: 221–225.
Peterson, T. G., and Barnes, S., 1991, Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene, Biochem. Biophys. Res. Commun. 179: 661–667.
Reynolds, B. D., Blackmon, W. J., Wickremesinhe, E., Wells, M. H., and Constantin, R. J., 1990, Domestication of Apios americana, In Advances in New Crops, Janick, J., and Simon, J. E., eds., Timber Press, Portland, OR, pp. 436–442.
Shelnutt, S. R., Cimino, C. O.. Wiggins, P. A, and Badger, T. M., 2000, Urinary pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein, Cancer Epidem. Biomark. Prevent. 9: 413–419.
Smith, M., Kirk, M., Weiss, H., Irwin, W., Urban D., Grizzle, W. E., and Barnes, S., 1999, Serum and urinary isoflavonoids and their metabolites in elderly men on diets supplemented with beverages containing untreated and alcohol-extracted soy protein, J. Med. Food 2: 219–222.
Stevens, J. F., Taylor, A.W., and Deinzer, M.L., 1999, Quantitative analysis of xanthohumol and related prenylflavonoids in hops and beer by liquid chromatography-tandem mass spectrometry, J. Chromatogr. A 832: 97–107.
Wang, C. C., Kirk, M., Smith, M., and Barnes, S., 2000, A highly sensitive method for the analysis of isoflavones in microliter samples of physiological fluids by nanoelectrospray mass spectrometry (nanoES-MS), 48th Natl. Mtg. Am. Soc. Mass Spectrom., Drugs and New Metabolism, 132 (abs.).
Wang, H-J., and Murphy, P. A., 1994, lsoflavone content in commercial soybean foods, J Agric. Food Chem. 42: 1666–1673.
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Barnes, S. et al. (2002). HPLC-Mass Spectrometry of Isoflavonoids in Soy and the American Groundnut, Apios Americana . In: Buslig, B.S., Manthey, J.A. (eds) Flavonoids in Cell Function. Advances in Experimental Medicine and Biology, vol 505. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5235-9_7
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