Abstract
Lipoamino acids are the substances which are present as the constituents of the cell membranes of relatively wide range of bacteria. As shown in Fig 1, the structures possess both hydrophobic lipid moiety and hydrophilic amino acid moiety (Ser or Orn) (3, 4, 5). We have investigated the structures and hemagglutinating activity of some lipoamino acids from Bordetella (3), Flavobacterium (4) and Pseudomonas (5). From these studies, it was resolved that the lipoamino acids possessing the fatty acids of carbon number 16–16 or 17–15 exhibit the higher hemagglutinating activity. Serine-containing lipid was found only in Flavobacterium and was named ‘Flavolipin’ by us (4). Based on these studies, we used this time the two kinds of lipoamino acids of Flavobacterium shown in Fig 1.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Akagawa, K. and Tokunaga, T., 1985. Lack of binding of bacterial lipopolysaccharide to mouse lung macrophages and restoration of binding by Y interferon. J. Exp. Med. 162: 1444.
Akagawa, K., Kamoshita, K., Onodera, S. and Tokunaga. T., 1987, Restoration of lipopolysaccharide-mediated cytotoxic macrophage induction in C3H/HeJ mice by interferon-or a calcium ionophore. Jpn. J. Cancer Res. ( Gann ) 78: 279.
Kawai, Y. and Yano, I., 1983, Ornithine-containing lipid of Bordetella, a new type of hemagglutinin. Eur. J. Biochem. 136: 531.
Kawai, Y., Yano, I. and Kaneda, K., 1988, Various kinds of lipoamino acids including a novel serine-containing lipid in an opportunistic pathogen Flavobacterium. Their structures and biological activities on erythrocytes. Eur. J. Biochem. 171: 73.
Kawai, Y., Yano, I., Kaneda, K., and Yabuuchi, E., 1988, Ornithine-containing lipids of some Pseudomonas species. Eur. J. Biochem. 175: 633.
Rietschel, E. Th., Shade, U., Jensen, M., Wollenweber, H. W., Luderitz, O. and Greisman, S. G., 1982, Bacterial endotoxins: chemical structure, biological activity and role in septicaemia. Scan. J. Infect. pis., Suppl., 31: 8.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Science+Business Media New York
About this chapter
Cite this chapter
Kawai, Y., Akagawa, K., Yano, I. (1990). Lipoamino Acids which are Similar to Bacterial Endotoxin in Both Structure and Biological Activity Related to Physiological Function. In: Friedman, H., Klein, T.W., Nakano, M., Nowotny, A. (eds) Endotoxin. Advances in Experimental Medicine and Biology, vol 256. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5140-6_13
Download citation
DOI: https://doi.org/10.1007/978-1-4757-5140-6_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-5142-0
Online ISBN: 978-1-4757-5140-6
eBook Packages: Springer Book Archive