Skip to main content

Biochemical Dynamics in Organized States: A Holistic Approach

  • Conference paper
Dynamics of Biochemical Systems

Part of the book series: Nato Science Series A: (closed) ((NSSA,volume 81))

Abstract

The key word in the title of this conference is “dynamics”. Indeed, this term comes closest to what we might call the defining characteristic of the “living state”.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Almási A, Fischer E, Perjési P: A simple and rapid ion-pair HPLC method for simultaneous quantitation of 4-nitrophenol and its glucuronide and sulfate conjugates. J. Biochem. Biophys. Methods 69, 43–50 (2006)

    Article  PubMed  Google Scholar 

  2. Almási A, Fischer E, Perjési P: Isocratic ion-pair HPLC method for quantitation of 4-nitrophenol and it’s conjugated metabolites from bile. Sci. Pharm. 79, 837–847 (2011)

    Article  PubMed Central  PubMed  Google Scholar 

  3. Ayrton A, Morgan P: Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica 31, 469–497 (2001)

    Article  CAS  PubMed  Google Scholar 

  4. Baldwin MK, Selby MA, Bloomberg H: Measurement of phenol in urine by the method of van Haaften and Sie: a critical appraisal. Analyst, 106, 763–767 (1981)

    Article  CAS  PubMed  Google Scholar 

  5. Barnes S, Buchina ES, King RJ, McBurnett T, Taylor KB: Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: purification, N-terminal amino acid sequence and kinetic properties. J. Lipid Res. 30, 429–440 (1989)

    Google Scholar 

  6. Beaumont K (2004): The importance of gut wall metabolism in determining drug bioavailibility. In: Drug Bioavailibility: Estimation of Solubility, Permeability, Absorption and Bioavailibility, eds van de Waterbeemd, Lenneraus H, Artursson P, Willey - VCH Verlag GmbH and Co. KgaA, Weinheim, FRG, Ch. 13, pp. 311–328

    Google Scholar 

  7. Capiello M, Franchi M, Giuliani L, Pacifici GM: Distribution of 2-naphthol sulfotransferase and its substrate adenosine 3-phosphate 5-phosphosulfate in human tissues. Eur. J. Clin. Pharmacol. 37, 317.320 (1989)

    Article  Google Scholar 

  8. Capiello M, Giuliani L, Pacifici GM: Distribution of UDP-glucuronyltransferase and its endogenous substrate uridine 5-diphosphoglucuronic acid in human tissues. Eur. J. Pharmacol. 41, 345.350 (1991)

    Google Scholar 

  9. Chen G, Battaglia E, Senay C, Falany CN, Radominska-Pandya A: Photoaffinity labeling probe for the substrate binding site of human phenol sulfotransferase (SULT1A1): 7-Azido-4-methylcoumarin. Protein Sci. 8, 2151. 2157 (1999)

    Article  PubMed  Google Scholar 

  10. Danovitch SH, Laster R: The development of arylsulfatase in the small intestine of the rat. Biochem. J. 114, 343–350 (1969)

    CAS  Google Scholar 

  11. Eadsforth CV, Coveney DC: Measurement of phenol in urine using a high-performance liquid chromatographic method. Analyst 109, 175–176 (1984)

    Article  CAS  PubMed  Google Scholar 

  12. Falany CN: Molecular enzymology of human cytosolic sulfortransferases. Trends Pharmacol. Sci. 12, 255–259 (1991)

    Article  CAS  PubMed  Google Scholar 

  13. Fischer E, Rafiei A, Bojcsev S: Intestinal elimination of p-nitrophenol in the rat. Acta Physiol. Hung. 83, 355–362 (1995)

    CAS  PubMed  Google Scholar 

  14. Fishman WH. (1974): ß-Glucuronidase. In: Methods of Enzymatic Analysis, ed Bergmeyer HU, Academic Press, New York, pp. 929–943

    Chapter  Google Scholar 

  15. George CF: Drug metabolism by gastrointestinal mucosa. Clin. Pharmacokinet. 6, 259–274 (1981)

    Article  CAS  PubMed  Google Scholar 

  16. Hartiala KJW: Metabolism of hormones, drugs and other substances by the gut. Physiol. Rev. 53, 496–534 (1973)

    CAS  PubMed  Google Scholar 

  17. Hänninen O, Lindström-Seppä P, Pelkonen K: Role of the gut in xenobiotic metabolism. Arch. Toxicol. 60, 34–36 (1987)

    Article  PubMed  Google Scholar 

  18. Inoue H, Yokota H, Taniyama H, Kuwahara H, Ogawa H, Kato S, Yuasa A: 1-Naphthol-ß-o-glucuronides formed intraluminally in rat small intestine mucosa and absorbed into the colon. Life Sci. 65, 1579–1588 (1999)

    Article  CAS  PubMed  Google Scholar 

  19. Koster AS, Noordhoek J: Glucuronidation in the rat intestinal wall. Comparison of isolated mucosal cells, latent microsomes and activated microsomes. Biochem. Pharmacol. 32, 895–900 (1983)

    CAS  Google Scholar 

  20. Kothare AP, Zimmerman CL: Intestinal metabolism: The role of enzyme localization in phenol metabolite kinetics. Drug Metab. Dispos. 30, 586–594 (2002)

    Article  CAS  PubMed  Google Scholar 

  21. Kuhn MD, Rost M, Müller D: Para-nitrophenol glucuronidation and sulphatation in rat and human slices. Exp. Toxic. Pathol. 53, 81–87 (2001)

    Article  CAS  Google Scholar 

  22. Laitinen M, Watkins JB (1986): Mucosal biotransformations. In: Gastrointestinal Toxicology, eds Rozman K, Hänninen O Elsevier Press, Amsterdam, pp. 169–192

    Google Scholar 

  23. Linn LH, Chiba M, Baillie TA: Is the role of the small intestine in first — pass metabolism overemphasized? Pharm. Rev. 51, 135–157 (1999)

    Google Scholar 

  24. Liu H, Wu B, Pan G, He L, Li Z, Fan M, Jian L, Chen M, Wang K, Huang C: Metabolism and pharmacokinetics of mangiferin in conventional rats, pseudo-germ-free rats, and streptozotocin-induced diabetic rats. Drug Metab. Dispos. 40, 2109–2118 (2012)

    Article  CAS  PubMed  Google Scholar 

  25. Maiti S, Grant S, Baker SM, Karanth S, Pope CN, Chen G: Stress regulation of sulfotransferases in male rat liver. Biochem. Biophys. Res. Commun. 323, 235–241 (2004)

    Article  CAS  Google Scholar 

  26. Mojarrabi B, Mackenzie PI: Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon. Biochem. Biophys. Res. Commun. 247, 704–709 (1998)

    Article  CAS  PubMed  Google Scholar 

  27. Pang KS, Maeng HJ, Fan J: Interplay of transporters and enzymes in drug and metabolite processing. Mol. Pharm. 6, 1734–1755 (2009)

    Article  CAS  PubMed  Google Scholar 

  28. Preuksaritonont T, Gorham LM, Hochman JH, Tran LO, Vyas KP: Comparative studies of drug metabolising enzymes in dog, monkey and human small intestines and in Caco-2-cells. Drug Metab. Disp. 24, 634–642 (1996)

    Google Scholar 

  29. Rafiei A, Bojcsev S, Fischer E: Dose-dependent intestinal and hepatic glucuronidation and sulfatation of p-nitrophenol in the rat. Acta Physiol. Hung. 84, 333–335 (1996)

    CAS  PubMed  Google Scholar 

  30. Schwenk M: Glucuronidation and sulphatation in gastrointestinal tract. Progr. Pharmacol. Clin. Pharmacol. 7, 155–169 (1989)

    CAS  Google Scholar 

  31. Shiratani H, Katoh M, Nakijama M, Yokoi T: Species differences in UDP-glucuronyltransferase activities in mice and rats. Drug Metab. Disp. 36, 1745–1752 (2008)

    Article  CAS  Google Scholar 

  32. Teubner W, Meinl W, Florian S, Kretzschmar M, Glatt H: Identification and localization of soluble sulfotransferases in the human gastrointestinal tract. Biochem. J. 404, 207–215 (2007)

    Article  CAS  PubMed  Google Scholar 

  33. Tukey RH, Strassburg CP: Human UDP-glucuronosyltransferases: metabolism, expression and disease. Ann. Rev. Pharmacol. Toxicol. 40, 581–616 (2000)

    Article  CAS  Google Scholar 

  34. van Norman KH: The biuret reaction and the cold nitric acid test in the recognition of protein. Biochem. J. 4, 127–135 (1909)

    PubMed  Google Scholar 

  35. Wu B, Kulkarni K, Basu S, Zhang S, Hu M: First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics. J. Pharm. Sci. 100, 3655–3681 (2011)

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer Science+Business Media New York

About this paper

Cite this paper

Welch, G.R. (1984). Biochemical Dynamics in Organized States: A Holistic Approach. In: Ricard, J., Cornish-Bowden, A. (eds) Dynamics of Biochemical Systems. Nato Science Series A: (closed), vol 81. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5034-8_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-5034-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5036-2

  • Online ISBN: 978-1-4757-5034-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics