Abstract
I might number the advantages of the linkage approach for testing hypotheses about allosteric interactions as four : Simplicity, Security, Insight and Suggestiveness. In reality these are all interconnected and are each aspect of one another.
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Whitehead, E.P. (1984). Subunit Interactions and Enzyme Kinetics: The Linkage Approach. In: Ricard, J., Cornish-Bowden, A. (eds) Dynamics of Biochemical Systems. Nato Science Series A: (closed), vol 81. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5034-8_3
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