Abstract
The repair of DNA damage is very much a minor activity in terms of the cellular resources devoted to it. This means that investigating the biochemistry of DNA repair is rather like looking for a needle in a haystack. Consequently, in attempts to account for the mechanism of nucleotide excision repair there has been undue reliance on guesswork and extrapolation. Only recently, with the cloning of bacterial DNA repair genes and the synthesis of gene products in substantial quantities, has it been possible to work out the details of excision repair in Escherichia coli — and, as we know, the conventional model has proven wrong.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cleaver, J.E., 1969, Repair replication of mammalian cell DNA: effects of compounds that inhibit DNA synthesis or dark repair, Radiat. Res., 37: 334.
Collins, A., 1987, Estimates of the rate of ligation during excision repair of ultraviolet-damaged DNA in mammalian cells, Biochim. Biophys. Acta 908: 103.
Collins, A., Black, D.T., and Waldren, C.A., 1987, Abortive DNA repair and enhanced mutagenesis following mutagen treatment of Chinese hamster Ade C cells in a state of purine deprivation, (submitted).
Collins, A.R.S., Downes, C.S., and Johnson, R.T., 1980, Cell cycle-related variations in UV damage and repair capacity in Chinese hamster (CHO-K1) cells, J. Cell. Physiol. 103: 179.
Collins, A.R.S., Downes, C.S., and Johnson, R.T., 1984, An integrated view of inhibited repair, in: “DNA Repair and its Inhibition”, A. Collins, C.S. Downes and R.T. Johnson, eds, IRL Press, Oxford.
Collins, A., and Johnson, R.T., 1979, Novobiocin; an inhibitor of the repair of UV-induced but not X-ray-induced damage in mammalian cells, Nucleic Acids Res. 7: 1311.
Collins, A.R.S., and Johnson, R.T., 1984, The inhibition of DNA repair, Adv. Radiat. Biol. 11: 71.
Collins, A., and Oates, D.J., 1987, Hydroxyurea: effects on deoxyribonucleotide pool sizes correlated with effects on DNA repair in mammalian cells, European J. Biochem. (in press)
Collins, A.R.S., Schor, S.L., and Johnson, R.T., 1977, The inhibition of repair in UV irradiated human cells, Mutat. Res., 42: 413.
Creissen, D., and Shall, S., 1982, Regulation of DNA ligase activity by poly(ADP-ribose), Nature 296: 271.
Downes, C.S., Ord, M.J., Mullinger, A.M., Collins, A.R.S., and Johnson, R.T., 1985, Novobiocin inhibition of DNA excision repair may occur through effects on mitochondrial structure and ATP metablism, not on repair topoisomerases, Carcinogenesis 6: 1343.
Johnson, R.T., Collins, A.R.S., Squires, S., Mullinger, A.M., Elliott, G.C., Downes, C.S., and Rasko, I., 1987, DNA repair under stress, J. Cell Sci. Suppl. 6: 263.
Lynch, W.E., Short, J., and Lieberman, I., 1976, The 7.1S nuclear DNA polymerase and DNA replication in intact liver, Cancer Res. 36: 901.
Mullinger, A.M., Collins, A.R.S., and Johnson, R.T., 1983, Cell growth state determines susceptibility of repair DNA synthesis to inhibition by hydroxyurea and 1- -D-arabinofuranosylcytosine, Carcinogenesis 4, 1039.
Reichard, P., 1972, Control of deoxyribonucleotide synthesis in vitro and in vivo, Adv. Enz. Regul., 10: 3.
Stamato, T.D., Hinkle, L., Collins, A.R.S., and Waldren, C.A., 1981, Chinese hamster ovary mutant UV-1 is hypomutable and defective in a postreplication recovery process, Somat. Cell Genet., 7: 307.
Th’ng, J.P.H., and Walker, I.G., 1986, Excision repair of DNA in the presence of aphidicolin, Mutat. Res., 165: 139.
Thompson, L.H., Brookman, K.W., Dillehay, L.E., Mooney, C.L., and Carrano, A.V., 1982, Hypersenstivity to mutation and sister-chromatid exchange induction in CHO cell mutants defective in incising DNA containing UV lesions, Somat. Cell Genet. 8: 759.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media New York
About this chapter
Cite this chapter
Collins, A. (1989). Inhibiting DNA Repair — Models, Manipulations and Misconceptions. In: Castellani, A. (eds) DNA Damage and Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5016-4_7
Download citation
DOI: https://doi.org/10.1007/978-1-4757-5016-4_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-5018-8
Online ISBN: 978-1-4757-5016-4
eBook Packages: Springer Book Archive