Abstract
Behavioral genetic analyses can be a powerful tool in identifying the mechanisms underlying specific pathophysiological states. The most recent approaches in this regard have involved transgenic or knockout mouse models. However, as many pathologies involve multiple gene effects, or an interaction between genes and environment, an alternative approach to assessing pathophysiology involves the use of rat/mouse lines selectively bred to exhibit high or low levels of a given phenotype. These lines can then be used to identify specific neuroanatomical, physiological and/or chemical correlates of the pathology.
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Mcintyre, D.C., Anisman, H. (2000). Anxiety and Impulse Control in Rats Selectively Bred for Seizure Susceptibility. In: Myslobodsky, M.S., Weiner, I. (eds) Contemporary Issues in Modeling Psychopathology. Neurobiological Foundation of Aberrant Behaviors, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4860-4_3
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DOI: https://doi.org/10.1007/978-1-4757-4860-4_3
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