Skip to main content
SpringerLink
Log in

Sites and Functions of the Blood-Retinal Barriers

  • Chapter
The Blood-Retinal Barriers

Abstract

Studies on the blood-brain relationship have yielded evidence that the rates of exchange and the concentrations in the brain at steady state for many substances are quite different from those in other organs. These differences reflect a distinct set of permeability characteristics at the blood-brain interface, thus originating the concept of a blood-brain barrier (BBB).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Schnaudigel, O. (1913) Albrecht von Graefes Arch. Ophthalmol., 86: 93–97.

    Google Scholar 

  2. Palm, E. (1947) Acta Ophthalmol., 25: 29–33.

    Google Scholar 

  3. Goldmann, E.E. (1913) Abhandl Konigl Preuss Akad Wiss, 1: 1–60.

    Google Scholar 

  4. Ashton, N. and Cunha-Vaz, J.G. (1965) Arch. Ophthalmol., 73: 211–223.

    Article  PubMed  CAS  Google Scholar 

  5. Majno, G. and Palade, G.E. (1961) J. Biophys. Biochem. Cytol., 11: 571–605.

    Google Scholar 

  6. Cunha-Vaz, J.G. (1976) Doc. Ophthalmol., 41: 287–327.

    Article  PubMed  CAS  Google Scholar 

  7. Archer, D.B. (1976) Doc. Ophthalmol. Proceedings Series, New Developments in Ophthalmology, The Hague W Junk, pp 155–167.

    Google Scholar 

  8. Cunha-Vaz, J.G., Abreu, J.R.F., Campos, A.J.,et al. (1975) British J. Ophthalmol., 59: 649–656.

    Article  CAS  Google Scholar 

  9. Cunha-Vaz, J.G., Goldberg, M.F., Vygantas, C. and Noth, J. (1979) Ophthalmology, 86: 264–275.

    PubMed  CAS  Google Scholar 

  10. Cunha-Vaz, J.G. (1979) Survey Ophthalmol., 23: 279–296.

    Google Scholar 

  11. Adler, F.H. (1962) Textbook of Physiology of the Eye. St. Louis, CV Mosby.

    Google Scholar 

  12. Bito, L.Z. (1977) Exp. Eye Res. 25 (Suppl.): 273–290.

    Article  PubMed  CAS  Google Scholar 

  13. Cunha-Vaz, J.G. and Maurice, D. (1967) J. Physiol., 191: 467–486.

    PubMed  CAS  Google Scholar 

  14. McMahon, R.T., Tso, M.O.M. and McLean, I.W. (1975) Amer. J. Ophthalmol., 80: 1058–1065.

    CAS  Google Scholar 

  15. Shakib, M. and Cunha-Vaz, J.G. (1966) Exp. Eye Res., 5: 229–234.

    Article  PubMed  CAS  Google Scholar 

  16. Staehelin, L.A., Mukherjee, T.M. and Williams, A.W. (1969) Protoplasma, 67: 165–184.

    Article  PubMed  CAS  Google Scholar 

  17. Cunha-Vaz, J.G., Shakib, M. and Ashton, N. (1966) Brit. J. Ophthalmol., 50: 441–453.

    Article  CAS  Google Scholar 

  18. Reese, T.S., Karnovski, M.J. (1967) J. Cell Biol., 34: 207–217.

    Article  PubMed  CAS  Google Scholar 

  19. Shiose, Y. (1970) Jap. J. Ophthalmol., 14: 73–79.

    Google Scholar 

  20. Smith, R.S. and Ruth, L.A. (1975) Invest. Ophthalmol., 14: 556–560.

    PubMed  CAS  Google Scholar 

  21. Nilausen, K. (1958) Acta Ophthalmol., 36: 65–69.

    Google Scholar 

  22. Wislocki, G.B. and Dempsey, E.W. (1948) J. Comp. Neurol., 88: 319–326.

    Google Scholar 

  23. Butler, A., Falck, B., Owman, C.H. and Rosengren, E. (1966) Pharmacol. Rev., 18: 369–385.

    Google Scholar 

  24. Hazétt, L.D. and Meyer, D.B. (1974) Exp. Eye Res., 19: 303–308.

    Article  Google Scholar 

  25. Cunha-Vaz, J.G. (1966) Permeability of the retinal vessels in health and disease. PhD thesis, University of London.

    Google Scholar 

  26. Peyman, G.A., Spitznas, M. and Straatsma, B.R. (1971) Invest. Ophthalmol., 10: 181–187.

    PubMed  CAS  Google Scholar 

  27. Shakib, M., Rutkowski, P. and Wise, G.E. (1972) Amer. J. Ophthalmol., 74: 206–218.

    CAS  Google Scholar 

  28. Steinberg, R.H. and Miller, S. (1973) Exp. Eye Res., 16: 365–372.

    Article  PubMed  CAS  Google Scholar 

  29. Gerschenfeld, H.M., Wald, F. and Zadunaisky, T.A. et al. (1959) Neurology, 9:412–425.’

    Google Scholar 

  30. Brightman, M.W. (1965) Am. J. Anat., 117: 191–220.

    Article  Google Scholar 

  31. Smelser, G.K., Ishikawa, T. and Pei, Y.F. (1965) Structure of the Eye, vol. 2 Stuttgart, Verlag, p. 109.

    Google Scholar 

  32. Dayson, H. (1969) The Eye, vol. 1, New York. Academic Press, ed. 2, PP. 67–186.

    Google Scholar 

  33. Bleeker, G.M. and Maas, E.H. (1958) Arch. Ophthalmol., 60. 1013–1020.

    Article  CAS  Google Scholar 

  34. Dayson, H., Duke-Elder, W.S., Maurice, D.M. et al. (1949) J. Physiol., 108: 203–217.

    Google Scholar 

  35. Sallman, L. von, Evans, T.C. and Dillon, B. (1949) Arch. Ophthalmol., 41: 611–626.

    Article  Google Scholar 

  36. Kinsey, K.E. (1960) Circulation, 21: 968–975.

    Article  PubMed  CAS  Google Scholar 

  37. Havener, W.H. (1974) Ocular Pharmacology. St. Louis, C.V. Mosby.

    Google Scholar 

  38. Vargas, F. and Johnson, J.A. (1967) Am. J. Physiol., 213: 87–93.

    PubMed  CAS  Google Scholar 

  39. Crone, C. (1965) Acta Physiol. Scand.., 64: 407–412.

    Article  PubMed  CAS  Google Scholar 

  40. Dayson, H. and Danielli, J.F. (1952) The Permeability of Natural Membranes. London, Cambridge University Press.

    Google Scholar 

  41. Oldendorf, W.H. (1975) Permeability of the Blood-Brain Barrier. In “The Nervous System”, Donald B. Tower, ed., vol. 1: The Basic Neurosciences, pp. 279–289, Raven Press, New York.

    Google Scholar 

  42. Zadunaisky, J.A. and Degnan, K.Y. (1976) Exp. Eye Res., 23: 191–196.

    Article  PubMed  CAS  Google Scholar 

  43. Miller, S. and Steinberg, R.H. (1976) J. Membrane Biol., 36: 3374372.

    Google Scholar 

  44. Dollery, C.T., Henkind, P. and D’Orme, M.L’E. (1971) Diabetes, 20: 519–524.

    PubMed  CAS  Google Scholar 

  45. Tornquist, P. (1979) Acta Univ. Upsaliensis, 326.

    Google Scholar 

  46. Bito, L.Z. (1970) Exp. Eye Res., 10: 102–116.

    Article  PubMed  CAS  Google Scholar 

  47. Cunha-Vaz, J.G. (1972) Trans. Ophthalmol. Soc. UK, 92: 111–121.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, University of Coimbra, Coimbra, Portugal

    Jose Cunha-Vas M.D., Ph.D.

  2. Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago, USA

    Jose Cunha-Vas M.D., Ph.D.

Authors
  1. Jose Cunha-Vas M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abraham Lincoln School of Medicine, University of Illinois College of Medicine, USA

    Jose G. Cunha-Vaz (Professor, Director, Professor and Chairman) (Professor, Director, Professor and Chairman)

  2. Retina Service, University of Illinois Eye and Ear Infirmary, Chicago, Illinois, USA

    Jose G. Cunha-Vaz (Professor, Director, Professor and Chairman) (Professor, Director, Professor and Chairman)

  3. Department of Opthalmology, University of Coimbra, Portugal

    Jose G. Cunha-Vaz (Professor, Director, Professor and Chairman) (Professor, Director, Professor and Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer Science+Business Media New York

About this chapter

Cite this chapter

Cunha-Vas, J. (1980). Sites and Functions of the Blood-Retinal Barriers. In: Cunha-Vaz, J.G. (eds) The Blood-Retinal Barriers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4655-6_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-4655-6_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4657-0

  • Online ISBN: 978-1-4757-4655-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation