Abstract
As part of our long standing interest in the etiology of atherosclerosis we are presently concentrating on an isolated moderate stenosis in a straight artery. The attack is three pronged, chronic in vivo experiments with healthy dogs, physical experiments in transparent models and approximate theoretical solutions. By studying the fluid dynamic field and the endothelial response we hope to establish the normal physiological state and thus be better able to define the disease mechanisms leading to deposition of atherosclerotic plaque.
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References
D. F. Young and F. Y. Tsai, “Flow characteristics in models of arterial stenosis — I. Steady Flow and U. Unsteady Flow,” J. Biomech. 6, 395–410 (1973).
M. D. Deshpande, D. P. Giddens, and R. F. Mabon, “Steady laminar flow through modelled vascular stenoses,” J. Biomech. 9, 165–174 (1976).
V. O’Brien and L. W. Ehrlich, “Pulsatile flow through stenosed arteries,” ASME 1977 Biomechanics Symp. (ASME AMD Vol. 23, pp. 113–116 ).
J. S. Lee and Y. C. Fung, “Flow in locally constricted tubes at low Reynolds numbers,” J. Appl. Mech. 37, 916 (1970).
L. W. Ehrlich, “The numerical solution of a NavierStokes problem in a stenosed tube: a danger in boundary approximations of implicit marching schemes,” Comp. & F1. 7, 247–256 (1979).
D. J. Schneck and F. J. Walburn, “Unsteady laminar-flow separation in tubes — II. The effect of variations in the frequency and amplitude of flow oscillations,” Rpt. VPI-E-79–21, June 1979.
V. O’Brien, L. W. Ehrlich and M. H. Friedman, “Unsteady flow in a branch,” J. F1. Mech. 75, 315–336 (1976).
S. F. Grace, “Oscillatory motion of a viscous liquid in a long straight tube,” Phil. Mag. 5, 933–939 (1928).
J. C. Bentz and N. A. Evans, “Hemodynamic flow in the region of a simulated stenosis,” ASME paper 75-WA/Bio10, 1975 (also Bentz Ph.D. thesis, Univ. Penna., 1974 ).
F. B. Gessner, “Hemodynamic theories of atherogenesis,” Circ. Res. 33, 259–266 (1973).
W. McMichael, “Interphase mass and heat transfer in pulsatile flow,” Ph.D. thesis, Rice Univ. (1973).
F. F. Mark, C. B. Bargeron, O. J. Deters, and M. H. Friedman, “Experimental investigations of steady and pulsatile laminar flow in a 90° branch,” Trans. ASME (JAM) 99E, 372–377 (1977); see also Proc. 28th ACEMB, 1975.
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© 1980 Springer Science+Business Media New York
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O’Brien, V., Ehrlich, L.W. (1980). Pulsatile Flow Through a Constricted Artery. In: Schneck, D.J. (eds) Biofluid Mechanics · 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4610-5_26
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DOI: https://doi.org/10.1007/978-1-4757-4610-5_26
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