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Neurohumoral, Renal, and Vascular Adjustments in Heart Failure

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Atlas of HEART FAILURE

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Abstract

Congestive heart failure resulting from left ventricular dysfunction is accompanied by peripheral circulatory changes that influence cardiac function and contribute to the clinical manifestations of heart failure. Neurohumoral systems that modulate both vascular tone and the retention of salt and water are activated. These include the sympathetic nervous system, the reninangiotensin-aldosterone system, arginine vasopressin, and the natriuretic peptides. In addition, the peripheral circulation undergoes local changes in response to heart failure that are fundamental to the pathophysiology of this disease state. Such changes include an increased release of endothelin and prostaglandins, as well as a possible decrease in the activity of nitric oxide. In addition, there may be enhanced local production of angiotensin II.

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Authors
  1. Anju Nohria
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  2. Jorge A. Cusco
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  3. Mark A. Creager
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Editor information

Editors and Affiliations

  1. Cardiovascular Medicine, Boston University Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA

    Wilson S. Colucci MD (Professor of Medicine, Chief) (Professor of Medicine, Chief)

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Nohria, A., Cusco, J.A., Creager, M.A. (2005). Neurohumoral, Renal, and Vascular Adjustments in Heart Failure. In: Colucci, W.S. (eds) Atlas of HEART FAILURE. Current Medicine Group, London. https://doi.org/10.1007/978-1-4757-4558-0_6

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  • DOI: https://doi.org/10.1007/978-1-4757-4558-0_6

  • Publisher Name: Current Medicine Group, London

  • Print ISBN: 978-1-4757-4560-3

  • Online ISBN: 978-1-4757-4558-0

  • eBook Packages: Springer Book Archive

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