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Significance of the Chronobiological Approach in Carrying Out Aging Studies

  • Chapter
Aging and Biological Rhythms

Part of the book series: Advances in experimental medicine and biology ((AEMB,volume 108))

Abstract

Chronobiology is the branch of science that explores mechanisms of biological time structure, including important rhythmic manifestations of life.

This work has been supported in part by U.S.P.H.S. Grant AM 12389.

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References

  • Bartter, F.C. Periodicity and Medicine. In: Chronobiology, L.E. Scheving, F. Halberg and J.E. Pauly, eds. Igaku Shoin Ltd., Tokyo, pp 6–13, 1974.

    Google Scholar 

  • Berson, S.A. and Yalow R.S. Radioimmunoassay of ACTH in plasma. J. Clin. Invest. 47: 2725, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Cornell, A.G., Bardawill, G.J. and David, M.M. Determination of serum proteins by means of the biuret reaction. J. Biol. Chem. 117: 751, 1949.

    Google Scholar 

  • Dunn, J.D., Scheving, L.E. and Millet, P. Circadian variation in stress-evoked increases in plasma corticosterone. Am. J. Physiol. 223: 402–406, 1972.

    PubMed  CAS  Google Scholar 

  • Dunn, J., Scheving, L.E., Pauly, J.E., Quittner, H. and Tsai, T.H. Effect of aging on the rhythmic pattern in serum corticosterone levels in rat maintained under different environmental lighting conditions. In: XII International Conference Proceedings, International Society for Chronobiology. Publishing House Il Ponte, Milano, pp 211–217, 1977.

    Google Scholar 

  • Enna, C.C., Scheving, L.E., Halberg, F., Jacobsen, R.R. and Mather, A. A study of circadian rhythms in various parameters in patients with leprosy. In: Chronobiology, L.E. Scheving, F. Halberg and J.E. Pauly, eds. Igaku Shoin Ltd., Tokyo, pp 280–284, 1974.

    Google Scholar 

  • Fisher, L.B. The diurnal mitotic rhythm in the human epidermis. Brit. J. Derm. 80: 75–80, 1968.

    Article  Google Scholar 

  • Fiske, C.H. and Sabbarow, Y. The colormetric determination of phosphorus. J. Biol. Chem. 66: 375, 1925.

    CAS  Google Scholar 

  • Guillemin, R., Clayton, G.W., Lipscomb, H.S. and Smith, J.D. Fluorometric measurement of rat plasma and adrenal corticosterone concentration. J. Lab. Clin. Med. 53: 830, 1958.

    Google Scholar 

  • Halberg, F. and Conner, R.L. Circadian organization and microbiology: Variance spectra and a periodogram on behavior of Escherichia coli growing in a fluid culture. Proc. Minn. Acad. Sci. 29: 227–239, 1961.

    Google Scholar 

  • Halberg, F., Johnson, F.A., Nelson, W., Runge, W. and Sothern, R. Autorhythmometry — procedures for physiologic self-measurement and their analysis. Physiol. Teacher 1: 1, 1972.

    Google Scholar 

  • Halberg, F., Lauro, R. and Carandente, F. Autorhythmometry. La Ricerca in Clinica e in Laboratorio 6: 207, 1976.

    PubMed  CAS  Google Scholar 

  • Haus, E. and Halberg, F. Circannual rhythm in level and timing of serum corticosterone in standardized inbred C-mice. Environmental Res. 3: 75–90, 1970.

    Article  Google Scholar 

  • Haus, E., Halberg, F., Scheving, L.E., Pauly, J.E., Cardoso, S.S., Kühl, J.F.W., Sothern, R.B., Shiotsuka, R. and Hwang, D.S. Increased tolerance of leukemic mice to arabinosyl cytosine with schedule adjusted to circadian system. Science 177: 80–82, 1972.

    Article  PubMed  CAS  Google Scholar 

  • Ho, Kang-Jey Effect of cholesterol feeding on circadian rhythm of hepatic and intestinal cholesterol biosynthesis in hamsters. Proc. Soc. Exp. Biol. Med. 150: 271, 1975.

    PubMed  CAS  Google Scholar 

  • Kanabrocki, E.L., Scheving, L.E., Halberg, F., Brewer, R.L. and Bird, T.J. Circadian variation in presumably healthy young soldiers. U.S. Dept. Commerce Doc. PB, 228427 p 56, 1974.

    Google Scholar 

  • Kanabrocki, E.L., Brewer, R.L., Scheving, L.E. and Pauly, J.E. Circadian fluctuation in urinary excretion of calcium and magnesium in presumably healthy young soldiers; effect of meal timing on the serum calcium rhythm. In: XII International Conference Proceedings, International Society for Chonogiology. Publishing House Il Ponte, Milano, pp 29–38, 1977.

    Google Scholar 

  • Kühl, J.F.W., Haus, E., Halberg, F., Scheving, L.E., Pauly, J.E., Cardoso, S.S. and Rosene, G. Experimental chronotherapy with ara-C; comparison of murine ara-C tolerance on differently timed treatment schedules. Chronobiologia 1: 316–317, 1974.

    Google Scholar 

  • Lakatua, D.J., Haus, E., Swoyer, J.K., Halberg, E., Thompson, M. and Sackett, L.L. Meal timing shifts circadian rhythms in serum iron and insulin but not in plasma cortisol in human volunteers. Chronobiologia 1: Suppl. 1: 39, 1975.

    Google Scholar 

  • Levin, H., Johnson, L.R., LaSalle, D.P. and Halberg, F. Autorhythmometry by secondary school students in Connecticut and Minnesota. In: Proc. First World Cong. Environmental Medicine and Biology. Excerpta Media, Paris, 1975 (in press).

    Google Scholar 

  • Mauer, A.M. Diurnal variation in proliferative activity in the human bone marrow. Blood 26: 1–2, 1965.

    PubMed  CAS  Google Scholar 

  • Mayersbach, H.V. Seasonal influences on biological rhythms of standardized laboratory animals. In: Cellular Aspects of Biorhythms, H.V. Mayersbach, ed. Springer-Verlag, Heidelberg, pp 87–99, 1967.

    Chapter  Google Scholar 

  • Mayersbach, H.V. Glycogen. In: Encyclopedia of Microscopy and Microtechnique, P. Gray, ed. Von Nostrand Reinhold, New York, pp 213–222, 1973.

    Google Scholar 

  • McLean, F.C. and Hastings, A.A. Clinical estimation and significance of calcium-ion concentrations in blood. Am. J. Med. Sci. 189: 601, 1935.

    Article  Google Scholar 

  • Nelson, W., Scheving, L.E. and Halberg, F. Circadian rhythms in mouse fed a single daily meal at different stages of the lighting regimen. J. Nutr. 105: 171–184, 1975.

    PubMed  CAS  Google Scholar 

  • Pauly, J.E., Burns, E.R., Halberg, F., Tsai, S., Betterton, H.O. and Scheving, L.E. Meal timing dominates lighting regime as a synchronizer of the eosinophil rhythm in mice. Acta. Anat. 93: 60–68, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Perault-Staub, A.M., Staub, J.F. and Milhaud, G. A new concept of plasma calcium homeostasis in the rat. Endocrinology 96: 480, 1974.

    Article  Google Scholar 

  • Philippens, K.M.H., Mayersbach, H.V. and Scheving, L.E. Effects of scheduling meal-feeding at different phases of the circadian system in rats. J. Nutr. 197: 176–193, 1977.

    Google Scholar 

  • Pincus, G. A diurnal rhythm of the excretion of urinary keto-steroids by young men. J. Clin. Endocrinol. 3: 195, 1943.

    Article  CAS  Google Scholar 

  • Robertson, W.G., Gallagher, J.C., Marshall, D.H., Peacock, M. and Norden, B.E.C. Seasonal variations in urinary excretion of calcium. Brit. Med. J. 4: 436, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Samis, H.V. Aging: The loss of temporal organization. Persp. Biol. Med. 12: 95, 1968.

    Google Scholar 

  • Scheving, L.E. Mitotic activity in the human epidermis. Anat. Rec. 135: 7–20, 1959.

    Article  PubMed  CAS  Google Scholar 

  • Scheving, L.E. Chronobiology. In: Chronobiology, L.E. Scheving, F. Halberg and J.E. Pauly, eds. Igaku Shoin Ltd., Tokyo, pp 221–223, 1974.

    Google Scholar 

  • Scheving, L.E. Chronobiology — a temporal dimension in biology and medicine. Endeavour XXXV (No. 125): 66–72, 1976.

    Article  Google Scholar 

  • Scheving, L.E. Temporal variation in man. In: Rhythmische Funktionen in Biologischen Systemen Part 1, G. Lassmann and F. Seitelberger, eds. Facultas-Verlag, Wien, pp 49–74, 1977.

    Google Scholar 

  • Scheving, L.E. and Dunn, J. The cyclic nature of prolactin in mammals. In: Chronobiological Aspects of Endocrinology, J. Aschoff, F. Ceresa and F. Halberg, eds. Symposia Medica Hoechst, Schattauer Verlag, Stuttgart, pp 193–201, 1974.

    Google Scholar 

  • Scheving, L.E. and Pauly, J.E. Effect of light on corticosterone levels in plasma of rats. Am. J. Physiol. 210: 1112–1117, 1966.

    PubMed  CAS  Google Scholar 

  • Scheving, L.E. and Pauly, J.E. Circadian phase relationships of thymidine-H3 uptake, labeled nuclei, grain counts and cell division rate in rat corneal epithelium. J. Cell. Biol. 32: 677–783, 1967.

    Article  PubMed  CAS  Google Scholar 

  • Scheving, L.E. and Pauly, J.E. Cellular mechanisms involving biorhythms with emphasis on those rhythms associated with the S and M stages of the cell cycle. Int. J. Chronobiology 1: 269–296, 1973.

    CAS  Google Scholar 

  • Scheving, L.E. and Pauly, J.E. Circadian rhythms: Some examples and comments on clinical applications. Chronobiologia 1: 3–21, 1974.

    PubMed  CAS  Google Scholar 

  • Scheving, L.E. and Pauly, J.E. Chronopharmacology — its implication for clinical medicine. In: Annual Reports in Medicinal Chemistry, Vol. 11, F.H. Clarke, ed. Academic Press, New York, pp 251–260, 1976.

    Google Scholar 

  • Scheving, L.E. and Pauly, J.E. Several problems associated with the conduct of chronobiological research. Nova Leopoldina (in press).

    Google Scholar 

  • Scheving, L.E., Vedral, D.F. and Pauly, J.E. A circadian susceptibility rhythm in rats to pentobarbital sodium. Anat. Rec. 160: 741–750, 1968a.

    Article  PubMed  CAS  Google Scholar 

  • Scheving, L.E., Vedral, D.F. and Pauly, J.E. Daily fluctuation (circadian) in levels of epinephrine in the rat suprarenal gland. Am. J. Physiol. 215: 799–802, 1968b.

    PubMed  CAS  Google Scholar 

  • Scheving, L.E., Cardoso, S.S., Pauly, J., Halberg, F. and Haus, E. Variations in susceptibility of mice to the carcinostatic agent arabinosyl cytosine. In: Chronobiology, L.E. Scheving, F. Halberg and J.E. Pauly, eds. Igaku Shoin Ltd., Tokyo, pp 213–217, 1974a.

    Google Scholar 

  • Scheving, L.E., Mayersbach, H.V. and Pauly, J.E. An overview of chronopharmacology — a general review. J. Europ. Toxicologie 7: 203–227, 1974b.

    CAS  Google Scholar 

  • Scheving, L.E., Pauly, J.E., Halberg, F., Tsai, T.H. and Betterton, H.O. Lighting regimen dominates interacting meal schedules and synchronizes mitotic rhythms in mouse corneal epithelium. Anat. Rec. 180: 47–52, 1974c.

    Article  PubMed  CAS  Google Scholar 

  • Scheving, L.E., Roig, C., Halberg, F., Pauly, J.E. and Hand, E.A. Circadian time structure in elderly people residing in a “senior citizens” home. In: Chronobiology, L.E. Scheving, F. Halberg and J.E. Pauly, eds. Igaku Shoin Ltd., Tokyo, pp 353–357, 1974d.

    Google Scholar 

  • Scheving, L.E., Haus, E., Kühl, J.F.W., Pauly, J.E., Halberg, F. and Cardoso, S.S. Different laboratories closely reproduce characteristics of circadian rhythm in ara-C tolerance by mice. Cancer Res. 36: 1133–1137, 1976.

    PubMed  CAS  Google Scholar 

  • Scheving, L.E., Halberg, F. and Kanabrocki, E.L. Circadian rhythmometry on variables of thirteen presumably healthy young men. Chronobiologia (in press).

    Google Scholar 

  • Simpson, H.W. A new prospective: Chronobiochemistry. Essay Med. Biochem. 2: 115, 1976.

    CAS  Google Scholar 

  • Stone, J.E., Polk, M.L., Tsai, T.H., Pauly, J.E., Burns, E.R. and Scheving, L.E. Circadian variation in urinary excretion of adenosine 3′5′ monophosphate (C-AMP) and guanosine 3′5′ mono-phosphate (G-GMP) in blinded human beings. In: XII International Conference Proceedings, International Society for Chronobiology. Publishing House Il Ponte, Milano, pp 321–326, 1977.

    Google Scholar 

  • Sturtevant, R.P. Circadian variability in Klebsiella demonstrated by cosinor analysis. Int. J. Chronobiology 1: 141–146, 1973.

    CAS  Google Scholar 

  • Tsai, T.H. Circadian variation in serum cholesterol levels of rat and man: Discussion of the circadian system of living organisms. Formosan Sci. 26: 67–90, 1972.

    CAS  Google Scholar 

  • Tsai, T.H., Scheving, L.E. and Pauly, J.E. Circadian rhythms of plasma inorganic phosphorus and sulfur of the rat. Also in suspectibility to strychnine. Jap. J. Physiol. 20: 12–29, 1970.

    Article  CAS  Google Scholar 

  • Yunis, E.J., Fernandes, G., Nelson, W. and Halberg, F. Circadian temperature rhythms and aging in rodents. In: Chronobiology, L.E. Scheving, F. Halberg and J.E. Pauly, eds. Igaku Shoin Ltd., Tokyo, 358–363, 1974.

    Google Scholar 

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Authors and Affiliations

  1. Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72201, USA

    Lawrence E. Scheving, John E. Pauly & Tien-Hu Tsai

Authors
  1. Lawrence E. Scheving
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  2. John E. Pauly
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  3. Tien-Hu Tsai
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Editor information

Editors and Affiliations

  1. Veterans Administration Center, Bay Pines, Florida, USA

    Harvey V. Samis Jr.

  2. Department of Chemistry, University of South Florida, Tampa, Florida, USA

    Harvey V. Samis Jr.

  3. University of Scranton, Scranton, Pennsylvania, USA

    Salvatore Capobianco

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© 1978 Springer Science+Business Media New York

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Scheving, L.E., Pauly, J.E., Tsai, TH. (1978). Significance of the Chronobiological Approach in Carrying Out Aging Studies. In: Samis, H.V., Capobianco, S. (eds) Aging and Biological Rhythms. Advances in experimental medicine and biology, vol 108. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4460-6_3

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  • DOI: https://doi.org/10.1007/978-1-4757-4460-6_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4462-0

  • Online ISBN: 978-1-4757-4460-6

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