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Circadian Rhythms in the Central Cholinergic System in Aging Animals

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Book cover Aging and Biological Rhythms

Part of the book series: Advances in experimental medicine and biology ((AEMB,volume 108))

Abstract

A number of changes in cyclically varying parameters during aging have been reported. These have included phase shifts in the diurnal distribution of spontaneous locomotor activity of rats (Mohan, 1975), mitotic index in the rat ear epithelium (Bullough, 1949), body temperature (Yunnis et al., 1974), urinary excretion of catecholamines (Descovich et al., 1974), eosinophil count (Halberg et al., 1955) and several other physiological parameters (Scheving et al., 1974).

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References

  • Albretch, P., Visscher, M.B., Bittner, J.J. and Halberg, F. Daily changes in 5-hydroxytryptamine in mouse brain. Proc. Soc. Exp. Med. 92: 703–706, 1956.

    Google Scholar 

  • Ansell, G.B. and Spanner, S. Studies on the origin of choline in the brain of the rat. Biochem. J. 122: 741–750, 1971.

    PubMed  CAS  Google Scholar 

  • Ansell, G.B. and Spanner, S. The origin and metabolism of brain choline. In: Cholinergic Mechanisms, P.G. Waser, ed. Raven Press, New York, pp 117–129, 1975.

    Google Scholar 

  • Artom, C. Nitrogenous constituents of phospholipids. In: Methods in Enzymology, Vol. 3, S.P. Colowick and N.O. Kaplan, eds. Academic Press, New York, pp 358–367, 1957.

    Chapter  Google Scholar 

  • Bullough, W.S. Age and mitotic activity in the male mouse, Mus musculus L. J. Exp. Biol. 26: 261–286, 1949.

    PubMed  CAS  Google Scholar 

  • Cohen, E.L. and Wurtman, R.J. Brain acetylcholine: increase after systemic choline administration. Life Sciences 16: 1095–1102, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Descovich, G.C., Montalbetti, N., Kuhl, J.F.W., Rimondi, S., Halberg, F. and Ceredi, C. Age and catecholamine rhythms. Chronobiologia 1: 163–171, 1974.

    PubMed  CAS  Google Scholar 

  • Fernstrom, J.D. and Wurtman, R.J. Nutrition and the brain. Sci. Amer. 230: 84–91, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Friedman, A.H. and Walker, C.A. Circadian rhythms in rat midbrain and caudate nucleus biogenic amine levels. J. Physiol.(London) 197: 77–85, 1968.

    PubMed  CAS  Google Scholar 

  • Friedman, A.H. and Walker, C.A. Circadian rhythms in central acetylcholine and the toxicity of cholinergic drugs. Fed. Proc. 28: 251, 1969.

    Google Scholar 

  • Frolkis, V.V. Regulation, Adaptation and Aging. Mauka, Leningrad, 1970.

    Google Scholar 

  • Frolkis, V.V., Bezrukov, V.V., Duplenko, Y.K., Shchegoleva, I.V., Shevtchuk, V.G. and Verkhratsky, N.S. Acetylcholine metabolism and cholinergic regulation of functions in aging. Gerontologia 19: 45–57, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Haga, T. and Noda, N. Choline uptake systems of rat brain synaptosomes. Biochem. Biophys. Acta. 291: 564–575, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Halberg, F., Bittner, J.J., Gully, R.J., Albretch, P.G. and Brackney, E.L. 24-hour periodicity and audiogenic convulsions in mice of various ages. Proc. Soc. Exp. Biol. Med. 88: 169–173, 1955.

    PubMed  CAS  Google Scholar 

  • Halberg, F., Tong, Y.L. and Johnson, E.A. Circadian system phase—an aspect of temporal morphology: Procedures and illustrative examples. In: Cellular Aspects of Biorhythms, H. v. Mayersbach, ed. Springer-Verlag, New York, p 20, 1967.

    Chapter  Google Scholar 

  • Halberg, F., Johnson, E.A., Nelson, W., Runge, W. and Sothern, R. Autorhythmometry — Procedures for physiological self-measurements and their analysis. Physiology Teacher 1: 1–11, 1972.

    Google Scholar 

  • Hanin, I., Massarelli, R. and Costa, E. Acetylcholine concentrations in rat brain: Diurnal oscillations. Science 170: 341–342, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Hestrin, S. The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine and its analytical applications. J. Biol. Chem. 180: 249, 1949.

    PubMed  CAS  Google Scholar 

  • Hollander, J. and Barrows, C.H. Enzymatic studies in senescent rodent brains. J. Gerontology 25: 174–179, 1968.

    Article  Google Scholar 

  • Illnerova, H. Effect of environmental lighting on serotonin rhythm in rat pineal gland during postnatal development. Life Sciences 10: 583–590, 1971.

    Article  CAS  Google Scholar 

  • Layne, E. Spectrophotometric and turbidimetric methods for measuring proteins. In: Methods in Enzymology, Vol. 3., S.P. Colowick and N.O. Kaplan, eds. Academic Press, New York, p 454, 1957.

    Google Scholar 

  • Massarelli, R., Hanin, I. and Costa, E. Diurnal rhythm of choline and acetylcholine in rat brain. Fed. Proc. 29: 417, 1970.

    Google Scholar 

  • Mayersbach, H. v. Seasonal influences on biological rhythms of standardized laboratory animals. In: Cellular Aspects of Biorhythms, H. v. Mayersbach, ed. Springer-Verlag, New York, p 87, 1967.

    Chapter  Google Scholar 

  • Mohan, C. Behavioural responses of aging rats to cholinergic and adrenergic drugs. Proc. V. Annual. Conf. Ethol. Soc. India, pp 22-23, 1975.

    Google Scholar 

  • Mohan, C. Effect of aging on some parameters of the central nervous system function and biochemistry. Ph.D. Thesis, Bangalore University, 1976.

    Google Scholar 

  • Mohan, C. and Radha, E. Circadian rhythms in acetylcholinesterase activity during aging of the central nervous system. Life Sciences 15: 231–237, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Morgan, W.W., Yndo, C.A. and McFadin, L.S. Daily rhythmic changes in the content of serotonin and 5-hydroxyindolacetic acid in the cerebral cortex of mice. Life Sciences 14: 329–338, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Moudgil, V.K. and Kanungo, M.S. Effect of age on the circadian rhythm of acetylcholinesterase of the brain of rat. Comp. Gen. Pharmacol. 4: 127–130, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Nachmansohn, D. and Wilson, I.B. Choline acetylase. In: Methods in Enzymology, Vol. 1, S.P. Colowick and N.O. Kaplan, eds. Academic Press, New York, pp 619–624, 1955.

    Chapter  Google Scholar 

  • Nikitin, V.N. and Martynenko, A.A. CoA content in tissues of white rats of different ages. In: Mekhanismy Stareniya. Kiev, pp 66-68, 1963.

    Google Scholar 

  • Quay, W.B. Regional and circadian differences in cerebral cortical serotonin concentration. Life Sciences 4: 379, 1965.

    Article  PubMed  CAS  Google Scholar 

  • Quay, W.B. Differences in circadian rhythms in 5-hydroxytryptamine according to brain region. Am. J. Physiol. 215: 1448–1453, 1968.

    PubMed  CAS  Google Scholar 

  • Reis, D.J., Wurtman, R.J., Weinbreb, M. and Corvelli, A. A circadian rhythm of norepinephrine regionally in cat brain; its relationship to environmental lighting and to regional diurnal variations in brain serotonin. J. Pharmacol. 164: 135–145, 1968.

    CAS  Google Scholar 

  • Saito, Y. The circadian rhythm of brain acetylcholine levels and motor activity in the rat. Life Sciences 10: 735–744, 1971.

    Article  CAS  Google Scholar 

  • Saito, Y., Yamashita, L., Yamazaki, K., Okada, F., Satomi, R. and Fujieda, T. Circadian fluctuations of brain acetylcholine in rats. I. On the variations in total brain and discrete areas. Life Sciences 16: 281–288, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Scheving, L.E., Harrison, W.H., Gordon, P. and Pauly, J.E. Daily fluctuation (circadian and ultradian) in biogenic amines of the rat brain. Am. J. Physiol. 214: 166–173, 1968.

    PubMed  CAS  Google Scholar 

  • Scheving, L.E., Roig, C., Halberg, F., Pauly, J.E. and Hand, E.A. Circadian variations in residents of a “senior citizens” home. In: Chronobiology, L.E. Scheving, F. Halberg and J.E. Pauly, eds. Igaku Shoin Ltd., Tokyo, pp 353–357, 1974.

    Google Scholar 

  • Schiebeier, H. and Mayersbach, H. v. Circadian variations of acetylcholinesterase in rat brain. Int. J. Chronobiol. 2: 281–289, 1974.

    Google Scholar 

  • Sorimachi, M. and Kataoka, K. Developmental changes of choline acetyl transferase and acetylcholinesterase in the ciliary and superior cervical ganglion of the chick. Brain Res. 70: 123–130, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Watterberg, L., Geller, E. and Yuwiler, A. Hardenian gland. An extraretinal photoreceptor influencing the pineal gland in neonatal rat. Science 167: 884–885, 1970.

    Article  Google Scholar 

  • Wurtman, R.J. and Axelrod, J. A 24-hour rhythm in the content of norepinephrine of the pineal and salivary glands of the rat. Life Sciences 5: 665–669, 1969.

    Article  Google Scholar 

  • Wurtman, R.J., Larin, F., Mostafapour, S. and Fernstrom, J.D. Brain catechol synthesis: Control by brain tyrosine concentration. Science: 185: 183–184, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Yamamura, H.I. and Snyder, S.H. High-affinity transport of choline into synaptosomes of rat brain. J. Neurochem. 21: 1355–1374, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Yunis, E.J., Fernandes, G., Nelson, W. and Halberg, F. Circadian temperature rhythms and aging in rodents. In: Chronobiology, L.E. Scheving, F. Halberg and J.E. Pauly, eds. Igaku Shoin Ltd., Tokyo, pp 358–363, 1974.

    Google Scholar 

  • Zweig, M., Snyder, S.H. and Axelrod, J. Evidence for a nonretinal pathway to the pineal gland of newborn rats. Proc. Natl. Acad. Sci. 56: 515–520, 1966.

    Article  PubMed  CAS  Google Scholar 

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Mohan, C., Radha, E. (1978). Circadian Rhythms in the Central Cholinergic System in Aging Animals. In: Samis, H.V., Capobianco, S. (eds) Aging and Biological Rhythms. Advances in experimental medicine and biology, vol 108. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4460-6_12

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  • DOI: https://doi.org/10.1007/978-1-4757-4460-6_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4462-0

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