Skip to main content
SpringerLink
Log in
Book cover

Advances in Nutritional Research pp 207–230Cite as

The Metabolism of Long-Chain Monoenoic Fatty Acids in Heart Muscle and Their Cardiopathogenic Implications

  • Chapter

Abstract

In the past decade, the attention of researchers working in the area of fat metabolism has focused on some possible adverse effects of long-chain unsaturated fatty acids in the diet. The principal sources of these long-chain monoenoic fatty acids are the commonly used vegetable and marine oils. The adverse nutritional effects in laboratory animals that have been associated with a daily high intake of vegetable or marine oils include an accumulation of fat in heart muscle (Abdellatif and Vles, 1970; Conacher et al., 1973; Teige and Beare-Rogers, 1973), myocarditis and myocardial focal necrosis (Roine et al., 1960), and even a possible increase in the incidence of intestinal and mammary tumors in laboratory animals (Enig et al., 1978).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abdellatif, A. M. M., and Vies, R. 0., 1970, Pathological effects of dietary rapeseed oil in rats, Nutr. Metab. 12: 285.

    CAS  Google Scholar 

  • Abdellatif, A. M. M., and Vles, R. O., 1973a, Short-term and long-term pathological effects of glyceryl trierucate and of increasing levels of dietary rapeseed oil in rats, Nutr. Metab. 15: 219.

    Article  CAS  Google Scholar 

  • Abdellatif, A. M. M., and Vles, R. O., 1973b, Pathological effects of dietary rapeseed oils with high or low erucic acid content in ducklings, Pauli. Sci. 52: 1932.

    Article  CAS  Google Scholar 

  • Ackman, R. G., 1966, Analysis of the monoethylenic fatty acids of rapeseed oil by open tubular gas chromatography, J. Am. Oil Chem. Soc. 43: 483.

    Article  CAS  Google Scholar 

  • Ackman, R. G., 1974, Marine lipids and fatty acids in human nutrition, in Fishery Products ( R. Kreuzer, ed.), pp. 112 - 131, The Whitefriars Press, London.

    Google Scholar 

  • Ackman, R. G., and Castell, J. D., 1966, Isomeric monoethylenic fatty acids in herring oil, Lipids 1: 341.

    Article  CAS  Google Scholar 

  • Ackman, R. G., and Loew, F. M., 1977, The effects of high levels of fats rich in erucic acid (from rapeseed oil) or cetoleic and cetelaidic acids (from partially hydrogenated fish oil) in a short-term study in a non-human primate species, Fette, Seifen, Anstrichm. 79: 15, 58.

    Article  CAS  Google Scholar 

  • Ackman, R. G., Epstein, S., and Eaton, C. A., 1971, Differences in the fatty acid compositions of blubber fats from northwestern Atlantic finwhales (Balaenoptera physalus) and harp seals (Pagophilus groenlandica), Comp. Biochem. Physiol. 40B: 683.

    Google Scholar 

  • Ackman, R. G., Hooper, S. N., and Hooper, D. L., 1974, Linolenic acid artifacts from the deodorization of oils, J. Am. Oil Chem. Soc. 51: 42.

    Article  CAS  Google Scholar 

  • Aherne, F. X., Bowland, J. P., Christian, R. G., Vogtmann, H., and Hardin, R. T., 1975, Performance and histological changes in tissues of pigs fed diets containing high or low erucic acid rapeseed oils or soybean oil, Can. J. Anim. Sci. 55: 77.

    Article  CAS  Google Scholar 

  • Aherne, F. X., Bowland, J. P., Christian, R. G., and Hardin, R. T., 1976, Performance of myocardial and blood serai changes in pigs fed diets containing high or low erucic acid rapeseed oils, Can. J. Anim. Sci. 56: 275.

    Article  CAS  Google Scholar 

  • Beare-Rogers, J. L., 1975, The effect of dietary rapeseed oil on cardiac tissue, in Modification of Lipid Metabolism ( E. G. Perkins and L. A. Witting, eds.), pp. 43 - 57. Academic Press, New York.

    Google Scholar 

  • Beare-Rogers, J. L., and Gordon, E., 1976, Myocardial lipids and nucleotides of rats fed olive oil or rapeseed oil, Lipids 11: 287.

    Article  CAS  Google Scholar 

  • Beare-Rogers, J. L., and Nera, E. A., 1972, Cardiac fatty acids and histopathology of rats, pigs, monkeys and gerbils fed rapeseed oil, Comp. Biochem. Physiol. 41B: 793.

    Google Scholar 

  • Beare-Rogers, J. L., and Nera, E. A., 1977, Nutritional effects of partially hydrogenated low erucic rapeseed oils, Lipids 12: 769.

    Article  CAS  Google Scholar 

  • Beare-Rogers, J. L., Nera, E. A., and Heggtveit, H. A., 1971, Cardiac lipid changes in rats fed oils containing long-chain fatty acids, Can. Inst. Food Technol. J. 4: 120.

    CAS  Google Scholar 

  • Beare-Rogers, J. L., Nera, E. A., and Craig, B. M., 1972a, Accumulation of cardiac fatty acids in rats fed synthesized oils containing C22 fatty acids, Lipids 7: 46.

    Article  CAS  Google Scholar 

  • Beare-Rogers, J. L., Nera, E. A., and Craig, B. M., 1972b, Cardiac lipids in rats and gerbils fed oils containing C22 fatty acids, Lipids 7: 548.

    Article  CAS  Google Scholar 

  • Beare-Rogers, J. L., Nera, E. A., and Heggtveit, H. A., 1974, Myocardial alteration in rats fed rapeseed oils containing high or low levels of erucic acid, Nutr. Metab. 17: 213.

    Article  CAS  Google Scholar 

  • Blomstrand, R., and Svensson, L., 1974, Studies on phospholipids with particular reference to cardiolipin of rat heart after feeding rapeseed oil, Lipids 9: 771.

    Article  CAS  Google Scholar 

  • Borensztajn, J., Rone, M. S., and Kotlar, T. J., 1976, The inhibition in vivo of lipoprotein lipase (clearing-factor lipase) activity by triton, WR-1339, Biochem. J. 156: 539.

    CAS  Google Scholar 

  • Brockerhoff, H., and Yurkowski, M., 1966, Stereospecific analyses of several vegetable fats, J. Lipid Res. 7: 62.

    CAS  Google Scholar 

  • Buddecke, E., Filipovic, I., Wortberg, B., and Seher, A., 1976, Wirkungsmechanismus langkettiger Monoenfettsäuren in Energiestoffwechsel des Herzens, Fette, Seifen, Anstrichm. 78: 196.

    Article  CAS  Google Scholar 

  • Carroll, K. K., 1965, Dietary fat and the fatty acid composition of tissue lipids, J. Am. Oil Chem. Soc. 42: 516.

    CAS  Google Scholar 

  • Carroll, K. K., 1966, Metabolism of C-labeled oleic acid, erucic acid and nervonic acid in rats, Lipids 1: 171.

    Article  CAS  Google Scholar 

  • Charlton, K. M., Corner, A. H., Davey, K., Kramer, J. K. G., Mahadevan, S., and Sauer, F. D., 1975, Cardiac lesions in rats fed rapeseed oils, Can. J. Comp. Med. 39: 261.

    CAS  Google Scholar 

  • Cheng, C. K., and Pande, S. V., 1975, Erucic acid metabolism by rat heart preparations, Lipids 10: 335.

    Article  CAS  Google Scholar 

  • Christiansen, R. Z., Christophersen, B. O., and Bremer, J., 1977, Monoethylenic C20 and C22 fatty acids in marine oil and rapeseed oil. Studies on their oxidation and on their relative ability to inhibit palmitate oxidation in heart and liver mitochondria, Biochim. Biophys. Acta 487: 28.

    Article  CAS  Google Scholar 

  • Christiansen, R. Z., Christiansen, E. N., and Bremer, J., 1979, The stimulation of erucate metabolism in isolated rat hepatocytes by rapeseed oil and hydrogenated marine oil-containing diets, Biochim. Biophys. Act 573: 417.

    Article  CAS  Google Scholar 

  • Christophersen, B. O., and Bremer, J., 1972, Erucic acid—an inhibitor of fatty acid oxidation in the heart, Biochim. Biophys. Acta 280: 506.

    Article  CAS  Google Scholar 

  • Christophersen, B. O., and Christiansen, R. Z., 1975, Studies on the mechanism of the inhibitory effects of erucylcarnitine in rat heart mitochondria, Biochim. Biophys. Acta 388: 402.

    Article  CAS  Google Scholar 

  • Clandinin, M., 1976, Fatty acid composition changes in mitochondrial membranes induced by dietary long chain fatty acids, FEBS Lett. 68: 41.

    Article  CAS  Google Scholar 

  • Conacher, H. B. S., and Page, B. D., 1972, Studies on the isomers of major monoenoic acids in rapeseed and partially hydrogenated rapeseed oil, J. Am. Oil Chem. Soc. 49: 283.

    Article  CAS  Google Scholar 

  • Conacher, H. B. S., Page, B. D., and Chadha, R. K., 1972, Isomers of monoethylenic fatty acids in some partially hydrogenated marine oils, J. Am. Oil Chem. Soc. 49: 520.

    Article  CAS  Google Scholar 

  • Conacher, H. B. S., Page, B. D., and Beare-Rogers, J. L., 1973, Monoethylenic isomers in cardiac lipids of rats fed partially hydrogenated herring oil, Lipids 8: 256.

    Article  CAS  Google Scholar 

  • Cornelius, J. A., 1977, Palm oil and palm kernel oil, in Progress in the Chemistry of Fats and Other Lipids ( R. T. Holman, ed.), pp. 5 - 27, Pergamon, Oxford.

    Google Scholar 

  • Craig, B. M., 1961, Varietal and environmental effects on rapeseed. III. Fatty acid composition of 1958 varietal tests, Can. J. Plant Sci. 41: 204.

    Article  CAS  Google Scholar 

  • Craig, B. M., and Beare-Rogers, J. L., 1967, The ß-oxidative degradation of docosenoic acids to eicosenoic and octadecenoic acids in the rat, Can. J. Biochem. 45: 1075.

    Article  CAS  Google Scholar 

  • Davidoff, F., and Korn, E. D., 1965, The reactions of trans-a, ß-hexadecenoyl coenzyme A and cis-and trans-ß, y-hexadecenoyl coenzyme A catalyzed by enzymes from guinea pig liver mitochondria, J. Biol. Chem. 240: 1549.

    CAS  Google Scholar 

  • Dewailly, P., Sezille, G., Nouvelot, A., Fruchart, J. C., and Jaillard, J., 1977, Changes in rat heart phospholipid composition after rapeseed oil feeding, Lipids 12: 301.

    Article  CAS  Google Scholar 

  • Dewailly, P., Nouvelot, A., Sezille, G., Fruchart, J. C., and Jaillard, J., 1978, Changes in fatty acid composition of cardiac mitochondrial phospholipids in rats fed rapeseed oil, Lipids 13: 301.

    Article  CAS  Google Scholar 

  • Downey, R. K., 1964, A selection of Brassica campestris L. containing no erucic acid in its seed oil, Can. J. Plant Sci. 44: 295.

    Article  CAS  Google Scholar 

  • Downey, R. K., 1976, Tailoring rapeseed and other oilseed crops to the market, Chem. and Ind. (London) May 1: 401.

    Google Scholar 

  • Downey, R. K., and Craig, B. M., 1964, Genetic control of fatty acid biosynthesis in rapeseed (Brassica napus L.), J. Am. Oil Chem. Soc. 41: 475.

    Article  CAS  Google Scholar 

  • Downey, R. K., Craig, B. M., and Youngs, C. G., 1969, Breeding rapeseed for oil and meal quality, J. Am. Oil Chem. Soc. 46: 121.

    Article  CAS  Google Scholar 

  • Dow-Walsh, D. S., Mahadevan, S., Kramer, J. K. G., and Sauer, F. D., 1975, Failure of dietary erucic acid to impair oxidative capacity or ATP production of rat heart mitochondria isolated under controlled conditions, Biochim. Biophys. Acta 396: 125.

    Article  CAS  Google Scholar 

  • Engfeldt, B., and Brunius, E., 1975, Morphological effects of rapeseed oil in rats. I. Short-term studies, Acta Med. Scand. (Suppl.) 585: 15.

    CAS  Google Scholar 

  • Enig, M. G., Munn, R. J., and Keeney, M., 1978, Dietary fat and cancer trends—a critique, Fed. Proc. 37: 2215.

    CAS  Google Scholar 

  • Friend, D. W., Corner, A. H., Kramer, J. K. G., Charlton, K. M., Gilka, F., and Sauer, F. D., 1975a, Growth, cardiopathology and cardiac fatty acids of swine fed diets containing soybean oil or low erucic acid rapeseed oil, Can. J. Anim. Sci. 55: 49.

    Article  CAS  Google Scholar 

  • Friend, D. W., Gilka, F., and Corner, A. H., 1975b, Growth, carcass quality and cardiopathology of boars and gilts fed diets containing rapeseed and soybean oils, Can. J. Anim. Sci. 55: 571.

    Article  CAS  Google Scholar 

  • Friend, D. W., Kramer, J. K. G., and Corner, A. H., 1976, Growth and cardiopathology in boars fed rapeseed oil, Can. J. Anim. Sci. 56: 361.

    Article  CAS  Google Scholar 

  • Garland, P. B., and Randle, P. J., 1964, Regulation of glucose uptake by muscle, Biochem. J. 93: 678.

    CAS  Google Scholar 

  • Garland, P. B., Shepherd, D., and Yates, D. W., 1965, Steady-state concentrations of coenzyme A, acetyl-coenzyme A and long-chain fatty acyl-coenzyme A in rat-liver mitochondria oxidizing palmitate, Biochem. J. 97: 587.

    CAS  Google Scholar 

  • Gopalan, C., Krishnamurthi, D., Shenolikar, I. S., and Krishnamachari, K. A. V. R., 1974, Myocardial changes in monkeys fed mustard oil, Nutr. Metab. 16: 352.

    Article  CAS  Google Scholar 

  • Gudbjarnason, S., and Hallgrimsson, J., 1976, The role of myocardial membrane lipids in the development of cardiac necrosis, Acta Med. Scand. (Suppl.) 587: 17.

    CAS  Google Scholar 

  • Gumpen, S. A., and Norum, K. R., 1973, The relative amounts of long-chain acylcarnitines, short-chain acylcarnitines and carnitine in heart, liver and brown adipose tissue from rats fed on rapeseed oil, Biochim. Biophys. Acta 316: 48.

    Article  CAS  Google Scholar 

  • Haeffner, E. W., 1970, Isolation and structural determination of the C20 and C22 unsaturated fatty acids of rapeseed oil, Lipids 5: 430.

    Article  CAS  Google Scholar 

  • Hay, J. D., and Morrison, W. R., 1970, Isomeric monoenoic fatty acids in bovine milk fat, Biochim. Biophys. Acta 202: 237.

    Article  CAS  Google Scholar 

  • Heijkenskjöld, L., and Ernster, L., 1975, Studies on the mode of action of erucic acid on heart metabolism, Acta Med. Scand. (Suppl.) 585: 75.

    Google Scholar 

  • Houtsmuller, U. M. T., Struijk, C. B., and Van der Beek, A., 1970, Decrease in rate of ATP synthesis of isolated rat heart mitochondria induced by dietary erucic acid, Biochim. Biophys. Acta 218: 564.

    Article  CAS  Google Scholar 

  • Hulan, H. W., Kramer, J. K. G., Mahadevan, S., Sauer, F. D., and Corner, A. H., 1976, Relationship between erucic acid and myocardial changes in male rats, Lipids 11: 9.

    Article  CAS  Google Scholar 

  • Hulan, H. W., Kramer, J. K. G., and Corner, A. H., 1977a, The effect of dietary fatty acid balance on myocardial lesions in male rats, Lipids 12: 951.

    Article  CAS  Google Scholar 

  • Hulan, H. W., Kramer, J. K. G., and Corner, A. H., 1977b, Myocardial lesions in rats fed rapeseed oil. I. Influence of strain of rats, Can. J. Physiol. Pharmacol. 55: 258.

    Article  CAS  Google Scholar 

  • Hulan, H. W., Thompson, B., Kramer, J. K. G., Sauer, F. D., and Corner, A. H., 1977c, An evaluation of the incidence of heart lesions in rats fed rapeseed oil, Can. Inst. Food Sci. Technol. J. 10: 23.

    CAS  Google Scholar 

  • Hung, S., and Holub, B. J., 1977, Effect of high-erucate rapeseed oil on lipid synthesis in rat heart, Nutr. Rep. Int. 15: 71.

    CAS  Google Scholar 

  • Idell-Wenger, J. A., Grotyohann, L. W., and Neely, J. R., 1978, Coenzyme A and carnitine distribution in normal and ischemic hearts, J. Biol. Chem. 253: 4310.

    CAS  Google Scholar 

  • Kerbey, A. L., Randle, P. J., Cooper, R. H., Whitehouse, S., Pask, H. T., and Denton, R. M., 1976, Regulation of pyruvate dehydogenase in rat heart, Biochem. J. 154: 327.

    CAS  Google Scholar 

  • Kishimoto, Y., and Radin, N. S., 1963, Biosynthesis of nervonic acid and its homologues from carboxyl-labeled oleic acid, J. Lipid Res. 4: 444.

    CAS  Google Scholar 

  • Korsrud, G. O., Conacher, H. B. S., Jarvis, G. A., and Beare-Rogers, J. L., 1977, Studies on long chain cis-and trans-acyl-CoA esters and acyl-CoA dehydrogenase from rat heart mitochondria, Lipids 12: 177.

    Article  CAS  Google Scholar 

  • Kramer, J. K. G., and Hulan, H. W., 1977, Changes in the acyl and alkenyl group composition of cardiac phospholipids in boars fed corn oil or rapeseed oil, Lipids 12: 159.

    Article  CAS  Google Scholar 

  • Kramer, J. K. G., and Hulan, H. W., 1978, The effects of dietary erucic acid on cardiac triglycerides and free fatty acid levels in rats, Lipids 13: 438.

    Article  CAS  Google Scholar 

  • Kramer, J. K. G., Mahadevan, S., Hunt, J. R., Sauer, F. D., Corner, A. H., and Charlton, K. M., 1973, Growth rate, lipid composition, metabolism and myocardial lesions of rats fed rapeseed oils (Brassica campestris var. Arlo, Echo and Span, and B. napus var. Oro), J. Nutr. 103: 1696.

    CAS  Google Scholar 

  • Kramer, J. K. G., Friend, D. W., and Hulan, H. W., 1975a, Lipid changes in tissues of young boars fed rapeseed oil or corn oil, Nutr. Metab. 19: 279.

    Article  CAS  Google Scholar 

  • Kramer, J. K. G., Hulan, H. W., Mahadevan, S., and Sauer, F. D., 1975b, Brassica campestris var. Span: I. Fractionation of rapeseed oil by molecular distillation and adsorption chromatography, Lipids 10: 505.

    CAS  Google Scholar 

  • Kramer, J. K. G., Hulan, H. W., Mahadevan, S., Sauer, F. D., and Corner, A. H., 1975c, Brassica campestris var. Span: II. Cardiopathogenicity of fractions isolated from Span rapeseed oil when fed to male rats, Lipids 10: 511.

    CAS  Google Scholar 

  • Kramer, J. K. G., Hulan, H. W., Procter, B. G., Rona, G., Mandavia, M. G., 1978, Evaluation of low erucic acid rapeseed oil fed to monkeys: Cardiac lipids, histochemistry and pathology, Can. J. Anim. Sci. 58: 257.

    Article  CAS  Google Scholar 

  • Kramer, J. K. G., Hulan, H. W., Trenholm, H. L., and Corner, A. H., 1979, Growth, lipid metabolism and pathology of two strains of rats fed high fat diets, J. Nutr. 109: 202.

    CAS  Google Scholar 

  • Kuemmel, D. F., 1964, Minor component fatty acids of common vegetable oils, J. Am. Oil Chem. Soc. 41: 667.

    CAS  Google Scholar 

  • Lall, S. P., Pass, D., and Slinger, S. J., 1972, Effect of high and low erucic acid rapeseed oil on biochemical and histopathological changes in heart muscle of chickens, Poult. Sci. 51: 1828.

    Google Scholar 

  • Lambertsen, G., Myklestad, H., and Braekkan, O. R., 1971, Studies on monoene fatty acid isomers in hydrogenated fish oils, J. Am. Oil Chem. Soc. 48: 389.

    Article  CAS  Google Scholar 

  • Lawhon, J. T., Cater, C. M., and Mattil, K. F., 1977, Evaluation of the food use potential of sixteen varieties of cottenseed, J. Am. Oil Chem. Soc. 54: 75.

    Article  CAS  Google Scholar 

  • Lazarow, P. B., and De Duve, C., 1976, A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug, Proc. Natl. Acad. Sci. 73: 2043.

    Article  CAS  Google Scholar 

  • Linn, T. C., Pettit, F. H., and Reed, L. J., 1969, a-Keto acid dehydrogenase complexes. X. regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation, Proc. Natl. Acad. Sci. 62: 234.

    Google Scholar 

  • Litchfield, C., 1971, The a,ß-distribution of oleic, linoleic and linolenic acids in cruciferae seed triglycerides, J. Am. Oil Chem. Soc. 48: 467.

    Article  CAS  Google Scholar 

  • Mahadevan, S., Malaiyandi, M., Erfle, J. D., and Sauer, F. D., 1970, Metabolism of L-carnitine esters of 0-substituted palmitic acid by rat liver mitochondria, J. Biol. Chem. 245: 3218.

    CAS  Google Scholar 

  • McCutcheon, J. S., Umemura, T., Bhatnagar, M. K., and Walker, B. L., 1976, Cardiopathogenicity of rapeseed oils and oil blends differing in erucic, linoleic and linolenic acid content, Lipids 11: 545.

    Article  CAS  Google Scholar 

  • Newsholme, E. A., Randle, P. J., and Manchester, K. L., 1962, Inhibition of the phosphofructokinase reaction in perfused rat heart by respiration of ketone bodies, fatty acids and pyruvate, Nature 193: 270.

    Article  CAS  Google Scholar 

  • Norseth, J., and Christophersen, B. 0., 1978, Chain shortening of erucic acid in isolated liver cells, FEBS Lett. 88: 353.

    CAS  Google Scholar 

  • Ohlson, R., 1972, Production of and trade in rapeseed, in Rapeseed ( L. A. Appelqvist and R. Ohlson, eds.), pp. 9 - 35, Elsevier, Amsterdam.

    Google Scholar 

  • Ohlson, R., Podlaha, O., and Töreg$rd, B., 1975, Stereospecific analysis of some cruciferae species, Lipids 10: 732.

    Article  CAS  Google Scholar 

  • Oram, J. F., Bennetch, S. L., and Neely, J. R., 1973, Regulation of fatty acid utilization in isolated perfused rat hearts, J. Biol. Chem. 248: 5299.

    CAS  Google Scholar 

  • Osmundsen, H., and Bremer, J., 1978, Comparative biochemistry of ß-oxidation. An investigation into the abilities of isolated heart mitochondria of various animal species to oxidize long-chain fatty acids, including the C22:1 monoenes, Biochem. J. 174: 379.

    CAS  Google Scholar 

  • Pande, S. V., 1975, A mitochondrial carnitine acylcamitine translocase system, Proc. Natl. Acad. Sci. 72: 883.

    Article  CAS  Google Scholar 

  • Pande, S. V., and Parvin, R., 1976, Characterization of carnitine acylcarnitine translocase system of heart mitochondria, J. Biol. Chem. 251: 6683.

    CAS  Google Scholar 

  • Pascal, J. C., and Ackman, R. G., 1976, Long chain monoethylenic alcohol and acid isomers in lipids of copepods and capelin, Chem. Phys. Lipids 16: 219.

    Article  CAS  Google Scholar 

  • Pinson, A., and Padieu, P., 1974, Erucic acid oxidation be beating heart cells in culture, FEBS Lett. 39: 88.

    Article  CAS  Google Scholar 

  • Rabinowitz, J. L., Hercker, E. S., 1974, Incomplete oxidation of palmitate and leakage of intermediary products during anoxia, Arch. Biochem. Biophys. 161: 621.

    Article  CAS  Google Scholar 

  • Randle, P. J., England, P. J., and Denton, R. M., 1970, Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart, Biochem. J. 117: 677.

    CAS  Google Scholar 

  • Rocquelin, G., 1973, Effets a très court terme de l’huile de colza sur les lipides cardiaques et hépatiques du rat sevré: Influence du raffinage et de l’intérestérification, Ann. Biol. Anim. Biochim. Biophys. 13: 151.

    CAS  Google Scholar 

  • Rocquelin, G., and Cluzan, R., 1968, L’huile de colza riche en acide érucique et l’huile de colza sans acide érucique: Valeur nutritionnelle et effets physiologiques chez le rat, Ann. Biol. Anim. Biochim. Biophys. 8: 395.

    Article  CAS  Google Scholar 

  • Rocquelin, G., Sergiel, J. P., Astorg, P. O., and Cluzan, R., 1973, Effets des huiles de colza et de canbra sur les lipides et l’anatomie du myocarde du rat: Étude a court terme (de 0 a 60 jours), Ann. Biol. Anim. Biochim. Biophys. 13: 587.

    Article  CAS  Google Scholar 

  • Roine, P. Uksila, E., Teir, H., and Rapola, J., 1960, Histopathological changes in rats and pigs fed rapeseed oil, Z. Ernährungswiss. 1: 118.

    Article  CAS  Google Scholar 

  • Sauer, F. D., 1974, Nutritional properties of Brassica campestris var. Span and its fractions when fed to rats and swine, Proceedings Internat. Rapskongres, Giessen, 4: 725.

    Google Scholar 

  • Shafrir, E., Gatt, S., and Khasis, S., 1965, Partition of fatty acids of 20-24 carbon atoms between serum albumin and lipoproteins, Biochim. Biophys. Acta 98: 365.

    Article  CAS  Google Scholar 

  • Stefansson, B. R., and Kondra, Z. P., 1975, Tower summer rape, Can. J. Plant Sci. 55: 343.

    Article  Google Scholar 

  • Stefansson, B. R., Hougen, F. W., and Downey, R. K., 1961, Note on the isolation of rape plants with seed oil free from erucic acid, Can. J. Plant Sci. 41: 218.

    Article  Google Scholar 

  • Stewart, H. B., Tubbs, P. K., and Stanley, K. K., 1973, Intermediates of fatty acid oxidation, Biochem. J. 132: 61.

    CAS  Google Scholar 

  • Swarttouw, M. A., 1974, The oxidation of erucic acid by rat heart mitochondria, Biochim. Biophys. Acta 337: 13.

    Article  CAS  Google Scholar 

  • Teige, B., and Beare-Rogers, J. L., 1973, Cardiac fatty acids in rats fed marine oils, Lipids 8: 584.

    Article  CAS  Google Scholar 

  • Trenholm, H. L., Thompson, B. K., and Kramer, J. K. G., 1979, An evaluation of the relationship of dietary fatty acids to incidence of myocardial lesions in male rats, Can. Inst. Food Sci. Technol. J. 12: 189.

    CAS  Google Scholar 

  • Vies, R. 0., 1975, Nutritional aspects of rapeseed oil, in The Role of Fats in Human Nutrition ( A. J. Vergroesen, ed.), pp. 433 - 477, Academic Press, New York.

    Google Scholar 

  • Vies, R. 0., Bijster, G. M., Kleinekoort, J. S. W., Timmer, W. G., and Zaalberg, J., 1976, Nutritional status of low-erucic acid rapeseed oils, Fette, Seifen, Anstrichm. 78: 128.

    Google Scholar 

  • Vodovar, N., Desnoyers, F., Levillain, R., and Cluzan, R., 1973, Accumulation lipidique térations cellulaires du myocarde des porcs ayant reçu de l’huile de colza dans leur régime. Etude ultrastructurale, C.R. Acad. Sci. 276D: 1597.

    CAS  Google Scholar 

  • Wakil, S. J., 1961, Mechanism of fatty acid synthesis, J. Lipid Res. 2: 1.

    Google Scholar 

  • Wieland, 0., Funcke, H., and Löffler, G., 1971, Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies, FEBS Lett. 15: 295.

    Article  Google Scholar 

  • Williamson, J. R., 1962, Effects of insulin and diet on the metabolism of L(+)-lactate and glucose by the perfused rat heart, Biochem. J. 83: 377.

    CAS  Google Scholar 

  • Williamson, J. R., 1964, Effects of insulin and starvation on the metabolism of acetate and pyruvate by the perfused rat heart, Biochem. J. 93: 97.

    CAS  Google Scholar 

  • Williamson, J. R., and Krebs, H. A., 1961, Acetoacetate as fuel of respiration in the perfused rat heart, Biochem. J. 80: 540.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Branch, Animal Research Institute, Agriculture Canada, Ottawa, Ontario, Canada

    Frank D. Sauer & John K. G. Kramer

Authors
  1. Frank D. Sauer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John K. G. Kramer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Guelph, Guelph, Ontario, Canada

    Harold H. Draper

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer Science+Business Media New York

About this chapter

Cite this chapter

Sauer, F.D., Kramer, J.K.G. (1980). The Metabolism of Long-Chain Monoenoic Fatty Acids in Heart Muscle and Their Cardiopathogenic Implications. In: Draper, H.H. (eds) Advances in Nutritional Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4448-4_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-4448-4_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4450-7

  • Online ISBN: 978-1-4757-4448-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation