Skip to main content
SpringerLink
Log in

Pathogenesis of Immune-Mediated Carditis in Monkeys

  • Chapter
Advances in Myocardiology

Abstract

An experimental model of carditis has been produced in the rhesus monkey by giving 12 weekly injections of streptococcal membrane antigen. Carditis was produced in as short a period as 14 weeks. There was evidence of myocarditis, endocarditis, and, in two animals, myocardial granuloma formation. No valvular lesions were seen. Measurement of immune responses showed that heart cross-reactive antibodies started appearing in the circulation after the second injection. By the sixth injection, there was evidence of complement consumption and appearance of circulating immune complexes. Antibody-dependent cell cytotoxicity started operating after the second injection, and by the sixth injection, peripheral lymphocytes had acquired hypersensitivity to membrane antigen. It is concluded that some of these immunologic responses might have played a role in the genesis of carditis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Chaturvedi, U. C., Davies, J. W., and Flewett, T. H. 1973. Separation and characterization of cardiac antigen proteins. Clin. Exp. Immunol. 15:613–622.

    PubMed  CAS  Google Scholar 

  2. Cromarti C. W. J., and Craddock, J. G. 1966. Rheumatic-like cardiac lesions in mice. Science154:285–287.

    Article  Google Scholar 

  3. Eckhardt, R., Kloos, P., Dierich, M. P., Meyer, Z., and Buschenfelde, K. H. 1977. K-lymphocytes (killer cells) in Crohn’s disease and acute virus B-hepatitis. Gut. 18:1010–1016.

    Article  PubMed  CAS  Google Scholar 

  4. Fürth, R., Van Zwet, T. L., and Leijh, P. C. J. 1978. In vitrodetermination of phagocytosis and intracellular killing by polymorphonuclear and monophagocytes. In: D. M. Weir (ed.), Handbook of Experimental Immunology, pp. 31.1–32.19. Blackwell ScientifiC., Oxford.

    Google Scholar 

  5. Ganguly, N. K., Chugh, K. S., Pal, Y., and Sapru, R. P. 1977. Comparative values of C’3 in normal rhesus monkeys. Indian J. Med. Res. 66:570–575.

    PubMed  CAS  Google Scholar 

  6. Ganguly, N. K., Sapru, R. P., and Mohan, C. 1977. Comparative evaluation of anti-hya-luronidase, antistreptolysin O and streptozyme tests in acute rheumatic activity. Indian J. Med. Res. 66:802–808.

    PubMed  CAS  Google Scholar 

  7. Goldstein, I., Halpern, B., and Robert L. 1967. Immunological relationship between streptococcus A polysaccharide and the structural glycoproteins of the heart valves. Nature213:44–47.

    Article  CAS  Google Scholar 

  8. Grant, J. 1978. Immunological methods in bacteriology. In: D. M. Weir (ed.), Handbook of Experimental Immunology, pp. 39.1–39.15. Blackwell ScientifiC., Oxford.

    Google Scholar 

  9. Hess, E. V., Fink, C. V., Taranta, A., and Ziff, M. 1964. Heart muscle antibodies in rheumatic fever and other diseases. J. Clin. Invest. 43:886–893.

    Article  PubMed  CAS  Google Scholar 

  10. Kaplan, M. H. 1965. Autoantibodies to heart and rheumatic fever, the induction of autoimmunity to heart by streptococcal antigen cross reactive with heart. Ann. N.Y. Acad. Sci. 124:904–915.

    Article  PubMed  CAS  Google Scholar 

  11. Kaplan, M. H. 1965. Induction of acute autoimmunity to heart in rheumatic fever by streptococcal antigen(s). Cross reaction with heart. Fed. Proc. 24:109–112.

    PubMed  CAS  Google Scholar 

  12. Kaplan, M. H., Bolande, R., and Rakita, L. 1964. Presence of bound immunoglobulins and complement in the myocardium in acute rheumatic fever. N. Engl. J. Med. 271:637–645.

    Article  PubMed  CAS  Google Scholar 

  13. Kaplan, M. H., and Meyserian, M. 1962. An immunological cross reaction between group A streptococcal cells and human heart tissue. Lancet1:706–710.

    Article  PubMed  CAS  Google Scholar 

  14. Kaplan, M. H., and Suce, K. H. 1964. Immunological relation of streptococcal and tissue antigens III. J. Exp. Med. 119:651–666.

    Article  PubMed  CAS  Google Scholar 

  15. Mohan, C. 1979. Pathogenecity of Group A Beta Haemolytic Streptococcus and Its L-Forms in Rhesus Monkeys. Ph.D. Thesis, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

    Google Scholar 

  16. Mohan, C., Ganguly, N. K., Chakravarti, R. N., and Chitkara, N. L. 1977. Prevalence of haemolytic streptococcal infection in rhesus monkeys. J. Hyg. Epidemiol. Microbiol. Immunol. (Praha)21:203–208.

    CAS  Google Scholar 

  17. Murphy, G. E., and Swift, H. F. 1950. The induction of rheumatic like cardiac lesions in rabbits by repeated focal infection with group A streptococci. Comparison with the cardiac lesions of serum disease. J. Exp. Med. 91:485–498.

    Article  PubMed  CAS  Google Scholar 

  18. Ohanion, S. H., and Schwab, J. H. 1967. Persistence of group A streptococcal cell walls related to chronic inflammation of rabbit dermal connective tissue. J. Exp. Med. 125:1137–1148.

    Article  Google Scholar 

  19. Pichler, W. J., and Krupp, M. 1977. Receptors of IgM coated erythrocytes on chronic lymphocytic leukemia cells. J. Immunol. 118:1010–1015.

    PubMed  CAS  Google Scholar 

  20. Quan, P. C., and Burtin, P. 1978. E-rosette forming cells at 29°C: An assay for the immune status of cancer patients. J. Cancer38:606–611.

    Article  CAS  Google Scholar 

  21. Qurrie, G. A., and Hedley, D. W. 1977. Monocyte and macrophage in malignant melanoma. Peripheral blood macrophage precursors. Br. J. Cancer36:1–6.

    Article  Google Scholar 

  22. Read, S. R., Fischetti, V. A., Utermohlen, V., Falk, R. E., and Zabriskie, J. B. 1974. Cellular reactivity studies to streptococcal antigens. Migration inhibition studies in patients with streptococcal infections and rheumatic fever. J. Clin. Invest. 54:439–450.

    Article  PubMed  CAS  Google Scholar 

  23. Rotta, J., and Tawil, G. S. 1976. Manual of Reference Procedures in Streptococcal Bacteriology and Serology. WHO Technical Report, World Health Organization, Geneva.

    Google Scholar 

  24. Sapru, R. P., Ganguly, N. K., Sharma, S., Chandnani, R. E., and Gupta, A. K. 1977. Cellular reactions to group A beta haemolytic streptococcal membrane antigen and its relation to complement levels in patients with rheumatic heart disease. Br. Med. J. 2:422–424.

    Article  PubMed  CAS  Google Scholar 

  25. Stollerman, G. H. 1975. Rheumatic Fever and Streptococcal Infection. Grune &; Stratton, New York.

    Google Scholar 

  26. Taranta, A. 1972. Rheumatic fever: Clinical aspects, In: J. L. Hollander and D. J. McCarty, (eds.), Arthritis and Allied Conditions, pp. 764–820. Lea & Febiger, Philadelphia.

    Google Scholar 

  27. Taranta, A., Cuppari, G., and Quagliata, F. 1969. Dissociation of hemolytic and lymphocyte transforming activities of streptolysin preparation. J. Exp. Med. 129:605–622.

    Article  PubMed  CAS  Google Scholar 

  28. Thomas, E. 1952. Rheumatic Fever: A Symposium. University of Minnesota Press, Minneapolis.

    Google Scholar 

  29. Varier Jones, J., and Cumming, R. N. 1977. Test for circulating immune complexes. In: R. A. Thompson (ed.), Techniques of Clinical Immunology, pp. 136–156. Blackwell ScientifiC., Oxford.

    Google Scholar 

  30. Van de Rijn, I., Zabriskie, J. B., and McCarty, M. 1977. Group A streptococcal antigens cross reactivity with myocardium purification of HRA and isolation and characterization of streptococcal antigen. J. Exp. Med. 146:579–599.

    Article  PubMed  Google Scholar 

  31. Yang, L. C., Soprey, P. R., Wittner, M. K., and Fox, E. N. 1977. Streptococcal induced cell mediated immune destruction of cardiac myofibres in vitro. J. Exp. Med. 146:344–360.

    Article  CAS  Google Scholar 

  32. Zabriskie, J. B., and Freimer, E. H. 1966. An immunological relationship between the group A streptococcus and mammalian muscle. J. Exp. Med. 124:661–678.

    Article  PubMed  CAS  Google Scholar 

  33. Zimmerman, R. A., Krushan, D. H., Wilson, E., and Douglas, J. D. 1970. Human streptococcal disease syndrome compared with observations in chimpanzees, III. Immunologic responses to induced pharyngitis and the effect of treatment. J. Infect. Dis. 122:280–289.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Cardiology, Parasitology, and Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    I. S. Anand, N. K. Ganguly, A. K. Khanna, R. N. Chakravarti & P. L. Wahi

Authors
  1. I. S. Anand
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. K. Ganguly
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. K. Khanna
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. N. Chakravarti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. L. Wahi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Cardiology Research Center, Academy of Medical Sciences, Moscow, USSR

    E. Chazov M.D.

  2. Institute of Pathology, McGill University, Montreal, Quebec, Canada

    G. Rona M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer Science+Business Media New York

About this chapter

Cite this chapter

Anand, I.S., Ganguly, N.K., Khanna, A.K., Chakravarti, R.N., Wahi, P.L. (1983). Pathogenesis of Immune-Mediated Carditis in Monkeys. In: Chazov, E., Saks, V., Rona, G. (eds) Advances in Myocardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4441-5_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-4441-5_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4443-9

  • Online ISBN: 978-1-4757-4441-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation