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Effects of Obesity on Lipid Metabolism

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Clinical Research in Diabetes and Obesity

Part of the book series: Contemporary Biomedicine ((CB,volume 15))

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Abstract

Obesity is a complex, heterogeneous disorder whose etiologic mechanisms are influenced by genetic, environmental, and neuroendocrine factors (1,2). Not only is obesity associated with excess body fat, but the biology of obesity is also influenced by size, location, and metabolism of the adipose tissue, as well as hormonal and neuroendocrine factors, all interacting to contribute to the associated health risks. Cardiovascular outcome is the sum total of multiple components, one of which is disturbances in lipid metabolism. Although the mechanisms behind the biology of these associations have been poorly understood, we now have the tools to study the underlying factors, in terms of both the genetic and neuroendocrinologic influences. This chapter describes the health risks associated with obesity and especially with abdominal/visceral obesity, with particular regard to effects on serum lipids and lipoproteins, and their relationship to insulin resistance and progression toward noninsulin-dependent diabetes mellitus (NIDDM).

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Authors
  1. Ahmed H. Kissebah
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  2. Glenn R. Krakower
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Editors and Affiliations

  1. Veteran’s Affairs Medical Center, Denver, CO, USA

    Boris Draznin

  2. Mayo Clinic, Rochester, MN, USA

    Robert Rizza

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Kissebah, A.H., Krakower, G.R. (1997). Effects of Obesity on Lipid Metabolism. In: Draznin, B., Rizza, R. (eds) Clinical Research in Diabetes and Obesity. Contemporary Biomedicine, vol 15. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-3906-0_5

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  • DOI: https://doi.org/10.1007/978-1-4757-3906-0_5

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-051-9

  • Online ISBN: 978-1-4757-3906-0

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