Abstract
We have now surveyed some of the principal methodological approaches of comparative genomics and the major evolutionary conclusions that can be inferred from genome comparisons. In this short chapter, we take a view of genomes from a different vantage point. We briefly describe the current understanding of the organization of the protein Universe and project it on genomes to reveal common and unique patterns.
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Further reading
Barabasi AL. 2002. Linked: The New Science of Networks. Perseus Publishing, Cambridge, MA.
Coulson AF, Moult J. 2002. A unifold, mesofold, and superfold model of protein fold use. Proteins 46, 61–71.
Huynen MA, van Nimwegen E. 1998. The frequency distribution of gene family sizes in complete genomes. Molecular Biology and Evolution 15, 583–589.
Koonin EV, Aravind L, Kondrashov AS. 2000. The impact of comparative genomics on our understanding of evolution. Cell 101, 573–576.
Qian J, Luscombe NM, Gerstein M. 2001. Protein family and fold occurrence in genomes: power-law behaviour and evolutionary model. Journal of Molecular Biology 313, 673–681.
Vitkup D, Melamud E, Moult J, Sander C. 2001. Completeness in structural genomics. Nature Structural Biology 8, 559–566.
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© 2003 Springer Science+Business Media Dordrecht
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Koonin, E.V., Galperin, M.Y. (2003). Genomes and the Protein Universe. In: Sequence — Evolution — Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3783-7_9
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DOI: https://doi.org/10.1007/978-1-4757-3783-7_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-5321-6
Online ISBN: 978-1-4757-3783-7
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