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Studies in the Human Frontal Cortex: Evidence for Changes in Neurochemical Markers in Schizophrenia and Bipolar Disorder

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Book cover The Postmortem Brain in Psychiatric Research

Part of the book series: Neurobiological Foundation of Aberrant Behaviors ((NFAB,volume 4))

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Abstract

Commonality of treatments in schizophrenia and bipolar disorder suggest that there may be a single pathology driving some of the symptoms of these illnesses. To test this hypothesis, the literature on the changes in the molecular neuroanatomy of postmortem brain tissue from subjects with schizophrenia and bipolar disorder has been reviewed to attempt to identify a common neurobiology. Such studies provide evidence to suggest that changes in the serotonergic system of the frontal cortex may be such a common factor. However, currently available data does not support the argument that the same changes in the serotonergic systems of the frontal cortex are present in schizophrenia and bipolar disorder. By contrast, such data would suggest that targeting receptor-G-protein interactions might be therapeutically beneficial in both illnesses.

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Authors
  1. Brian Dean
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Editors and Affiliations

  1. Stanley Foundation International Research Center and Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel

    Galila Agam  & R. H. Belmaker  & 

  2. Departments of Neuropathology and Psychological Medicine, Institute of Psychiatry, DeCrespigny Park, SE5 8AF, London, UK

    Ian Paul Everall

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© 2002 Springer Science+Business Media New York

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Dean, B. (2002). Studies in the Human Frontal Cortex: Evidence for Changes in Neurochemical Markers in Schizophrenia and Bipolar Disorder. In: Agam, G., Everall, I.P., Belmaker, R.H. (eds) The Postmortem Brain in Psychiatric Research. Neurobiological Foundation of Aberrant Behaviors, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3631-1_7

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  • DOI: https://doi.org/10.1007/978-1-4757-3631-1_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-4921-9

  • Online ISBN: 978-1-4757-3631-1

  • eBook Packages: Springer Book Archive

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