Abstract
In the CNS, opening of voltage-dependent Ca2+ channels (VDCCs) in response to action potentials triggers synaptic neurotransmission. The presynaptic VDCCs consist of three types of Cav2 channel family, formerly known as N-, P/Q- and R-types. Although the modulation of N-type channels by G protein-coupled receptors has been extensively studied so far, little is known about the regulation of P/Q-type channels. To elucidate this point, we have investigated the interaction of α2 and β adrenergic receptors with P/Q-type channels by functional coexpression in Xenopus oocytes.
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References
G. W. Zamponi and T. P. Snutch, Modulation of voltage-dependent calcium channels by G proteins, Curr. Opin. Neurobiol. 8, 351–356 (1998).
B. M. Denker, E. J. Neer, and C. J. Schmidt, Mutagenesis of the amino terminus of the a subunit of the G protein G0, J. Biol. Chem. 267, 6272–6277 (1992).
K. P. M. Currie and A. P. Fox, Comparison of N- and P/Q-type voltage-gated calcium channel current inhibition, J. Neurosci. 17, 4570–4579 (1997).
T. Furukawa, R. Miura, Y. Mori, M. Strobeck, K. Suzuki, Y. Ogihara, T. Asano, R. Morishita, M. Hashii, H. Higashida, M. Yoshii, and T. Nukada, Differential interactions of the C terminus and the cytoplasmic I-H loop of neuronal Ca2+ channels with G-protein a and β? subunits. II. evidence for direct binding, J. Biol. Chem. 273, 17595–17603 (1998).
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Kaneko, S., Kinoshita, M., Kanadzu, M., Akaike, A., Satoh, M. (2002). G-Protein-Mediated Regulation of P/Q-Type Calcium Channels by α2 and β Adrenergic Receptors Exogenously Expressed in Xenopus Oocytes. In: Nagatsu, T., Nabeshima, T., McCarty, R., Goldstein, D.S. (eds) Catecholamine Research. Advances in Behavioral Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3538-3_59
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DOI: https://doi.org/10.1007/978-1-4757-3538-3_59
Publisher Name: Springer, Boston, MA
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