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Imaging of Apoptosis and Hypoxia

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Targeted Molecular Imaging in Oncology

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Abstract

Tumor cells are more sensitive to conventional irradiation in the presence of oxygen than in its absence; even a small percentage of hypoxic cells within a tumor could limit the response to radiation [1–4]. Hypoxic radioresistance has been demonstrated in many animal tumors but only in a few tumor types in humans [5–9]. The occurrence of hypoxia in human tumors has, in most cases, been inferred from histological findings and from animal tumor studies. In vivo demonstration of hypoxia has required tissue measurements with oxygen electrodes, and the invasiveness of these techniques has limited their clinical application. Additionally, this technique can only be used on accessible tumors such as head and neck tumor. Many attempts to increase the radiosensitivity of tumors by administration of chemical radiosensitizers have not been successful [10–14].

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Authors
  1. David J. Yang
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  2. E. Edmund Kim
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Editors and Affiliations

  1. Departments of Nuclear Medicine and Diagnostic Radiology, The University of Texas M.D. Anderson Cancer Center, 77030, Houston, TX, USA

    E. Edmund Kim MD  & David J. Yang PhD  & 

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Yang, D.J., Kim, E.E. (2001). Imaging of Apoptosis and Hypoxia. In: Kim, E.E., Yang, D.J. (eds) Targeted Molecular Imaging in Oncology. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3505-5_18

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  • DOI: https://doi.org/10.1007/978-1-4757-3505-5_18

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-3507-9

  • Online ISBN: 978-1-4757-3505-5

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