Abstract
A large series of evidence has conclusively demonstrated that the development and progression of a cancer are due to the accumulation of a number of genetic alterations which finally result in a full malignant phenotype. This complex phenomenon is clearly illustrated by colorectal tumors, which often require more than a decade to be clinically evident and at least seven genetic events for completion.1
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Della Ragione, F. et al. (1999). Cell Division Cycle Alterations and Human Tumors. In: Zappia, V., Della Ragione, F., Barbarisi, A., Russo, G.L., Iacovo, R.D. (eds) Advances in Nutrition and Cancer 2. Advances in Experimental Medicine and Biology, vol 472. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3230-6_8
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DOI: https://doi.org/10.1007/978-1-4757-3230-6_8
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