Abstract
Slight changes in the intacellular redox equilibrium is a physiological situation utilized by nature to regulate many important cell functions (Sundaresan et al., 1995). However, when the level of the oxidizing substances produced exceeds a certain threshold it becomes deleterious for the cells (Halliwell and Gutteridge, 1989). The main source of oxidizing agents is the monovalent reduction of oxygen to superoxide anion and the subsequent formation of reactive oxygen intermediates (ROI) (Figure 1).
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Galaris, D., Kokkoris, S., Toumpoulis, I., Korantzopoulos, P. (1998). The Molecular Mechanism of Interaction of H2O2 with Metmyoglobin. In: Özben, T. (eds) Free Radicals, Oxidative Stress, and Antioxidants. NATO ASI Series, vol 296. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2907-8_9
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