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Vitamin D pp 101–107Cite as

The Vitamin D Binding Protein and Its Clinical Significance

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Part of the book series: Nutrition and Health ((NH))

Abstract

The plasma protein that transports vitamin D and its metabolites [vitamin D binding protein (DBP)] was first recognized as a postalbumin component of human sera during electrophoretic analyses (1). Subsequently, the identity of this group-specific component (Gc-globulin) and plasma DBP was discovered (2) and confirmed (3). The protein is synthesized in the liver and displays features homologous with albumin and α-fetoprotein (4). Neither of the latter proteins binds vitamin D sterols with high affinity, however. DBP is 122 amino acids shorter than albumin and α-fetoprotein, and the genes of all three of these proteins map to human chromosome 4g11–22 (4).

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Authors
  1. John G. Haddad
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Editors and Affiliations

  1. Boston University Medical Center, Boston, MA, USA

    Michael F. Holick PhD, MD

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© 1999 Springer Science+Business Media New York

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Haddad, J.G. (1999). The Vitamin D Binding Protein and Its Clinical Significance. In: Holick, M.F. (eds) Vitamin D. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2861-3_6

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  • DOI: https://doi.org/10.1007/978-1-4757-2861-3_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-2863-7

  • Online ISBN: 978-1-4757-2861-3

  • eBook Packages: Springer Book Archive

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